Evolving Tumor Characteristics and Smart Nanodrugs for Tumor Immunotherapy.

Typical physiological characteristics of tumors, such as weak acidity, low oxygen content, and upregulation of certain enzymes in the tumor microenvironment (TME), provide survival advantages when exposed to targeted attacks by drugs and responsive nanomedicines. Consequently, cancer treatment has significantly progressed in recent years. However, the evolution and adaptation of tumor characteristics still pose many challenges for current treatment methods.

Exosome-Transmitted miR-25 Induced by Promotes Vascular Endothelial Cell Injury by Targeting KLF2.

Increasing evidence has shown that is associated with coronary heart disease (CHD); however, the underlying mechanism remains unclear. The expression of miR-25 and mRNAs was measured using qRT-PCR. Protein levels were detected using western blotting and exosomes were assessed with an electron microscope.

Computed tomography-magnetic resonance imaging fusion-guided iodine-125 seed implantation for single malignant brain tumor: Feasibility and safety.

Background: To investigate the feasibility and safety of computed tomography-magnetic resonance imaging (CT-MRI) fusion-guided iodine-125 seed implantation for a single malignant brain tumor.

Methods: From November 2015 to October 2016, 12 patients with a single malignant brain tumor were treated with permanent iodine-125 seeds implantation. CT-MRI fusion images were used to make the preoperative treatment plan, intraoperative dose optimization, postoperative verification, and tumor response follow-up.

[Cultivation of aerobic granular sludge with municipal wastewater and studies on its characteristics under the continuous flow].

The aerobic granular sludge was cultivated successfully in a continuous-flow airlift aerobic granular sludge fluidized bed (CAFB), with low-concentration municipal sewage as the influent and flocculent activated sludge as the seeding sludge. The formation, characteristics and the biological diversity of the aerobic granules in the CAFB were investigated and analyzed. Experimental results showed that many dense and compact granules with diameter of 800-1 000 microm were formed as early as the 6th days operation.

Down-regulation of ALKBH2 increases cisplatin sensitivity in H1299 lung cancer cells.

Aim: To elucidate the combined effect of alkylated DNA repair protein alkB homolog 2 (ALKBH2)-targeting gene therapy and cisplatin (cDDP) chemotherapy on the non-small cell lung cancer (NSCLC) H1299 cell line.

Methods: ALKBH2 was down-regulated in H1299 cells by lentivirus-mediated RNA interference (RNAi). Changes in ALKBH2 expression were determined using real-time RT-PCR and Western blotting.

Light coupling and modulation in coupled nanowire ring-Fabry-Pérot cavity.

CdS nanowire (NW) ring cavities were fabricated and studied for the first time. The rings with radii from 2.1 to 5.

[Method for concentration determination of mineral-oil fog in the air of workplace].

Objective: To study the method of concentration determination of mineral-oil fog in the air of workplace.

Methods: Four filter films such as synthetic fabric filter film, beta glass fiber filter film, chronic filter paper and microporous film were used in this study. Two kinds of dust samplers were used to collect the sample, one sampling at fast flow rate in a short time and the other sampling at slow flow rate with long duration.