Publications by authors named "Shi-Duo Zhang"
Future Med Chem
October 2024
Article Synopsis
- Protein-protein interactions (PPIs) are essential for biological functions and are linked to various human diseases, making them important targets for drug development.
- The cGAS-STING pathway is crucial for regulating the immune system and is associated with several health issues, drawing significant research interest in its modulators.
- This review highlights recent progress in drug discovery related to cGAS-STING PPIs and suggests new strategies for developing potential treatments targeting this pathway.
Article Synopsis
- ABCB1 and ABCG2 are crucial transporters linked to multidrug resistance (MDR), and this study developed imidazo[1,2-]pyridine derivatives aimed at inhibiting both targets.
- One of the compounds demonstrated significant inhibition of the efflux function of both transporters without causing noticeable cytotoxicity and improved the effects of antiproliferative drugs in the lab.
- The compound worked by slightly reducing ATPase activity and not altering the expression of the transporters, suggesting it could be a useful addition to standard chemotherapy treatments in overcoming resistance.
