Publications by authors named "Shi-Cheng Liu"
Background: Colorectal cancer (CRC), the fourth of the world's major common malignancy, poses a serious threat to the physical and mental health of the population. Nevertheless, the prognosis of CRC patients remains unsatisfactory. Consequently, it is still imperative to continuously discover the CRC mechanisms.
View Article and Find Full Text PDFBackground: Ketamine is famous for its dissociative anesthetic properties. It is also analgesic, anti-inflammatory and anti-depressant, and even has a cerebral protective effect. We searched the evidence of the correlation between ketamine target and clinical efficacy and utilized network pharmacology to gather information about the multi-target mechanism of ketamine against cerebral ischemia (CI).
View Article and Find Full Text PDFcollagenases of the M9A subfamily are closely related to pathogenesis for their role in collagen degradation during host invasion. Although some collagenases have been characterized, the collagen degradation mechanism of collagenase is still largely unknown. Here, an M9A collagenase, VP397, from marine Vibrio pomeroyi strain 12613 was characterized, and its fragmentation pattern on insoluble type I collagen fibers was studied.
View Article and Find Full Text PDFThe collagenases of Vibrio species, many of which are pathogens, have been regarded as an important virulence factor. However, there is little information on the structure and collagenolytic mechanism of Vibrio collagenase. Here, we report the crystal structure of the collagenase module (CM) of Vibrio collagenase VhaC and the conformation of VhaC in solution.
View Article and Find Full Text PDFArticle Synopsis
- * After optimizing hydrolysis conditions to achieve 99.4% efficiency, the resulting collagen peptides demonstrate excellent moisture retention and a strong antioxidative capability with a scavenging ratio of 73.2%.
- * The findings suggest that TLP A69 has significant potential for application in various industries, including cosmetics, food, and pharmaceuticals, promoting the valuable use of bovine bone collagen.
Article Synopsis
- The text references a correction to a previously published article with the DOI: 10.1371/journal.pone.0045412.
- This correction likely addresses errors or updates needed for the original research findings or data.
- Such corrections are important in academic publishing to maintain the integrity and accuracy of scientific literature.
Background: COMMD7 is a newly identified gene overexpressed in hepatocellular carcinoma (HCC) and associated with tumor invasion and poor prognosis. We aim to examine the biological function of COMMD7 in HCC by shRNA silencing.
Methods: COMMD7 expressions were examined in human HCC cell lines HepG2, Huh7, Hep3B, HLE, HLF, SK-Hep-1 and PLC/PRF/5 cells.