Two new steroidal sapogenins from (synonym ) rhizomes and their antifungal activity.

Two novel acylated steroidal sapogenins, 3-acetoxy-1, 2, 4, 5, 7-pentahydroxy-spirost-25(27)-en-6-one () and (25S)-3-acetoxy-1, 2, 4, 5, 7-pentahydroxyspirostan-6-one (), together with two known steroidal sapogenins ( and ), were isolated from rhizomes. Their structures were elucidated by nuclear magnetic resonance (NMR) and mass spectrometry (MS) data. In addition, the antifungal activities of the isolated compounds against and were evaluated.

2,3,6-Trichloro-5-(trichloro-meth-yl)pyridine.

The title compound, C(6)HCl(6)N, lies on a mirror plane, the asymmetric unit conataining a half-mol-ecule. Weak intra-molecular C-H⋯Cl contacts are observed.

Syntheses and antibacterial activity of Schiff bases from 16-isopropyl-5, 9-dimethyltetracyclo [10.2.2.0(1, 10).0(4, 9)] hexadec-15-ene-5, 14-dicarboxylic acid.

16-isopropyl-5, 9-dimethyltetracyclo [10.2.2.

16-Isopropyl-5,9-dimethyl-tetra-cyclo-[10.2.2.0.0]hexa-dec-15-ene-5,13,14-trimethanol ethanol monosolvate.

The title compound, C(24)H(40)O(3)·C(2)H(6)O, is a substituted tetra-cyclo-[10.2.2.

16-Isopropyl-5,9-dimethyl-tetra-cyclo-[10.2.2.0.0]hexa-dec-15-ene-5,14-dimethanol.

The title compound, C(23)H(38)O(2), a tetra-cyclo-[10.2.2.

(1R,4aS,10aR)-1,4a-Dimethyl-N-[(morpholin-4-yl)carbothio-yl]-7-(propan-2-yl)-1,2,3,4,4a,9,10,10a-octa-hydro-phenanthrene-1-carboxamide.

In the title compound, C(25)H(36)N(2)O(2)S, the cyclo-hexane and morpholine rings adopt chair conformations. The cyclo-hexene and cyclo-hexane rings form a trans ring junction with the two methyl groups in axial positions. The N-H and C=O bonds in the urea group are anti to each other.

4-Isopropyl-N-phenyl-cyclo-hexa-1,3-diene-1-carboxamide.

In the crystal structure of the title compound, C(16)H(19)NO, mol-ecules are linked through a pair of N-H⋯O hydrogen bonds, forming chains along the a axis.

16-Isopropyl-5,9-dimethyl-tetra-cyclo-[10.2.2.0.0]hexa-dec-15-ene-5,13,14-tricarboxylic acid dimethyl-formamide disolvate.

The title compound, C(24)H(34)O(6)·2C(3)H(7)NO, which was isolated from fumaric-modified rosin, has four asymmetrically fused six-membered rings and three carboxylic acid substituents. It contains two fused and unbridged cyclo-hexane rings, which form a trans ring junction with a chair conformation. The asymmetric unit includes one fumaropimaric acid and two dimethyl-formamide mol-ecules.

Methyl 12-bromo-dehydro-abietate.

THE TITLE COMPOUND [SYSTEMATIC NAME: (1R)-methyl 6-bromo-7-isopropyl-1,4a-dimethyl-1,2,3,4,4a,9,10,10a-octa-hydro-phen-anthrene-1-carboxyl-ate], C(21)H(29)BrO(2), was synthesized from N-bromo-succinimide and methyl dehydro-abietate, which was prepared through an esterification reaction using dehydro-abietic acid and methanol as raw materials. The three six-membered rings adopt planar (mean deviation = 0.002 Å) half-chair and chair conformations.

N-Benzyl-idenenordehydro-abietylamine.

THE TITLE COMPOUND [SYSTEMATIC NAME: (1R,4aS,10aR,E)-N-benzyl-idene-7-isopropyl-1,4a-dimethyl-1,2,3,4,4a,9,10,10a-octa-hydro-phenanthren-1-amine], C(26)H(33)N, has been synthesized from nor-dehydro-abietylamine and benzaldehyde. The two cyclo-hexane rings form a trans ring junction with classic chair and half-chair conformations, respectively, the two methyl groups are on the same side of tricyclic hydro-phenanthrene structure. The dihedral angle between two benzene rings is 44.

16-Isopropyl-5,9-dimethyltetra-cyclo-[10.2.2.0.0]hexa-dec-15-ene-5,14-dicarboxylic acid ethanol hemisolvate.

In the title compound, C(23)H(34)O(4)·0.5C(2)H(6)O, which was isolated from acrylic modified rosin, the endocyclic compound adopts a tetra-cyclo-[10.2.

7-Isopropyl-1,4a-dimethyl-1,2,3,4,4a,5,6,7,8,9,10,10a-dodeca-hydro-phenan-threne-1-carboxylic acid.

The title compound, C(20)H(32)O(2), has been isolated from hydrogenated rosin. There are two independent mol-ecules in the asymmetric unit. In each mol-ecule, the cyclo-hexane ring assumes a chair conformation, while the two cyclo-hexene rings adopt half-chair and envelope conformations.

2-Hydr-oxy-6,6-dimethyl-bicyclo-[3.1.1]heptane-2-carboxylic acid.

The title compound, C(10)H(16)O(3), with a bicyclo-[3.1.1]heptane unit, was obtained by oxidation of β-pinene.

15-Hydroxy-ethyl-19-isopropyl-5,9-dimethyl-14,16-dioxo-15-aza-penta-cyclo-[10.5.2.0.0.0]nona-dec-18-ene-5-carboxylic acid.

The title compound, C(26)H(37)NO(5), which was synthesized from monoethano-lamine and maleopimaric acid, consists of two fused and unbridged cyclo-hexane rings. They form a trans ring junction with a chair conformation. The two methyl groups are in axial positions.

Dehydro-abietic acid.

THE TITLE COMPOUND [SYSTEMATIC NAME: (1R,4aS,10aR)-7-iso-prop-yl-1,4a-dimethyl-1,2,3,4,4a,9,10,10a-octa-hydro-phen-anthrene-1-carboxylic acid], C(20)H(28)O(2), has been isolated from disproportionated rosin which is obtained by isomerizing gum rosin with a Pd-C catalyst.. Two crystallographically independent mol-ecules exist in the asymmetric unit.

2-[(1S,3S)-3-Acetyl-2,2-dimethyl-cyclo-butyl]-N-(m-tol-yl)acetamide.

The title compound, C(17)H(23)NO(2), contains two chiral centres and was synthesized from 2-(3-acetyl-2,2-dimethyl-cyclo-butyl)acetic acid and m-toluidine. The cyclobutane ring is not flat but flexed as though folded from the dimethyl-substituted C atom to the unsubstituted C atom, with a dihedral angle of 25.9°.