Publications by authors named "Shi-An Hu"
Tumor necrosis factor receptor-associated factor 1 (TRAF1) is a crucial signaling adaptor involved in multiple cellular events. However, its role in regulating osteoclastogenesis and energy metabolism remains unclear. Here, we report that TRAF1 promotes osteoclastogenesis and oxidative phosphorylation (OXPHOS).
View Article and Find Full Text PDFTraditional Chinese medicine (TCM) possesses the potential of providing good curative effects with no side effects for the effective management of slow transit constipation (STC), an intestinal disease characterized by colonic dyskinesia. Mulberry leaves L.) and black sesame ( L.
View Article and Find Full Text PDFActivating Nrf2 by small molecules is a promising strategy to treat postmenopausal osteoporosis. However, there is currently no Nrf2 activator approved for treating chronic diseases, and the downstream mechanism underlying the regulation of Nrf2 on osteoclast differentiation remains unclear. Here, we found that bitopertin, a clinical-stage glycine uptake inhibitor, suppresses osteoclast differentiation and ameliorates ovariectomy-induced bone loss by activating Nrf2.
View Article and Find Full Text PDFArticle Synopsis
- Inflammatory bowel disease (IBD) is a chronic condition affecting the gastrointestinal tract, influenced by genetics, the microbiome, and immune responses, primarily caused by a disrupted intestinal mucosal barrier.
- NOD-like receptors (NLRs) are crucial for maintaining the integrity of the intestinal mucosal barrier and play significant roles in sensing gut bacteria and controlling inflammation.
- The review discusses how botanicals that inhibit NLR inflammasome activation could potentially help prevent the worsening of IBD, while proposing new research directions for understanding and treating the disease.