Publications by authors named "Shi Yang Wang"
Background: The prognostic value of an effective biomarker, pan-immune-inflammation value (PIV), for head and neck squamous cell carcinoma (HNSCC) patients after radical surgery or chemoradiotherapy has not been well explored. This study aimed to construct and validate nomograms based on PIV to predict survival outcomes of HNSCC patients.
Methods: A total of 161 HNSCC patients who underwent radical surgery were enrolled retrospectively for development cohort.
Article Synopsis
- This study explores the timing and methods for assessing measurable residual disease (MRD) in acute myeloid leukemia (AML), suggesting that MRD assessment after two cycles of consolidation treatment is more effective than after induction.
- The results show that multiparameter flow cytometry (MFC) MRD provides significant prognostic value for relapse-free and overall survival in AML patients, especially when analyzing specific gene mutations.
- Combining MFC MRD with molecular MRD techniques can enhance risk stratification, though the choice of method should depend on the patient's genetic characteristics related to AML.
Article Synopsis
- Acute myeloid leukaemia (AML) presents a complex prognosis due to various patient and disease factors, despite new treatment advancements.
- A study identified several key prognostic factors (like age and genetic mutations) that can help predict overall survival, leading to a predictive model for individual risk assessment.
- This model shows strong performance in differentiating survival outcomes for young and elderly patients and could assist in treatment decisions, particularly for stem cell transplant eligibility.
Article Synopsis
- A study compared clinical and genetic characteristics among elderly AML (e-AML), secondary AML (s-AML), and young de novo AML patients, finding distinct mutation patterns and lower blood cell counts in e-AML and s-AML groups.
- e-AML and s-AML patients had lower rates of complete remission and shorter survival times compared to younger patients, indicating a need for different treatment strategies.
- Intensive therapy may enhance survival for e/s-AML patients without increasing early death risks, and hematopoietic stem cell transplantation is recommended for treating fit s-AML patients.
Article Synopsis
- Hepatocellular carcinoma (HCC) is a major health issue, ranking as the third leading cause of cancer-related deaths, with around 850,000 new cases each year, often diagnosed too late for surgical intervention.
- The development of HCC is linked to various genetic "driver mutations" that enable cancer cells to thrive and are crucial for developing targeted therapies for patients with advanced stages of the disease.
- This review highlights the current knowledge of driver mutations, identifies methods for discovering these genetic changes, and categorizes targeted drugs for HCC, emphasizing the potential for improved treatments through precision medicine.
Human umbilical tissue-derived cells (hUTC) represent an attractive cell source and a potential technology for neurorestoration and improvement of functional outcomes following stroke. Male Wistar rats were subjected to a transient middle cerebral artery occlusion (tMCAo) and were intravenously administered hUTC (N = 11) or vehicle (N = 10) 48 hrs after stroke. White matter and vascular reorganization was monitored over a 12-week period using MRI and histopathology.
View Article and Find Full Text PDFCell therapy promotes brain remodeling and improves functional recovery after various central nervous system disorders, including traumatic brain injury (TBI). We tested the hypothesis that treatment of TBI with intravenous administration of human marrow stromal cells (hMSCs) provides therapeutic benefit in modifying hemodynamic and structural abnormalities, which are detectable by in vivo MRI. hMSCs were labeled with superparamagnetic iron oxide (SPIO) nanoparticles.
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