Randomized metalens array homogenizer for enhanced laser beam shaping.

We present a beam homogenizer utilizing on a random metalens array (RMA) for enhanced beam shaping. The RMA, comprising 28 × 28 individual metalenses with random sizes, is designed using an improved Gerchberg-Saxton algorithm. As a laser beam traverses the RMA, it is divided into 28 × 28 beams, each exhibiting a unique speckle pattern.

Polarized adding method of discrete ordinate approximation for ultraviolet-visible and near-infrared radiative transfer.

The polarization characteristics of atmospheric scattering are important for planetary studies and should not be ignored in radiative transfer simulations. In this study, what we believe to be a new vector radiative transfer model called the polarized adding method of discrete ordinate approximation (POLDDA) is proposed for use in remote sensing applications for ultraviolet-visible and near-infrared spectra. The single-layer radiative transfer process and inhomogeneous multi-layer connection are solved using the discrete ordinate method (DOM) and adding methods, respectively.

Rapid, autonomous and ultra-large-area detection of latent fingerprints using object-driven optical coherence tomography.

The detection of latent fingerprints plays a crucial role in criminal investigations and biometrics. However, conventional techniques are limited by their lack of depth-resolved imaging, extensive area coverage, and autonomous fingerprint detection capabilities. This study introduces an object-driven optical coherence tomography (OD-OCT) to achieve rapid, autonomous and ultra-large-area detection of latent fingerprints.

Influencing Factors of Self-Management Behavior Among Chinese Patients With Chronic Disease: A Cross-Sectional Study.

Aims: This study aimed to describe the self-management behavior levels and further explore its influencing factors among patients with chronic disease.

Design: A cross-sectional study.

Methods: 460 convenient samples of patients with chronic disease in Zhejiang Province were investigated using a demographic characteristics questionnaire, the Lubben Social Network Scale (LSNS-6), and the Chronic Disease Self-Management Behavior Scale between October and December 2023.

Spatial differentiation and influencing factors of heavy metals in soils of typical counties in Lhasa river basin.

This paper studied the spatial distribution and influencing factors of heavy metals (HMs) such as Cu, Pb, Zn, Cr, Ni, Cd and As in the soil of Linzhou County in the Lhasa River basin. By collecting 504 surface soil samples, using descriptive statistics, Kriging interpolation and geoaccumulation index methods, combined with the geographic detector model, the spatial distribution characteristics of soil HMs content and its interaction with 19 environmental factors were systematically analyzed.The results showed that the content of heavy metals in the soil in this area was generally higher than the background value of soil in Lhasa, especially Cd and As, which showed strong spatial heterogeneity, suggesting the existence of specific pollution sources.

Nomogram models for predicting myocardial ischemia under high altitude exposure: a cohort study.

Background: Exposure to high altitude increases the risk of myocardial ischemia (MI) and subsequent cardiovascular death. Nomogram is a graphical regression model, but there are no reports on using nomogram to predict myocardial ischemia under high altitude exposure. Our goal was to establish prediction models based on pre-high-altitude physical exposure examination data and identify key risk factors.

Peripheral nerve-derived CSF1 induces BMP2 expression in macrophages to promote nerve regeneration and wound healing.

The precise mechanisms regulating inflammatory and prorepair macrophages have not been fully elucidated, despite the pivotal role played by innate immunity in wound healing. We first employed a denervation wound model to validate the crosstalk between neurons and macrophages. Compared to normal wound healing, the denervation wound healing process involved fewer macrophages, decreased angiogenesis, and delayed wound healing.

A potent broad-spectrum neutralizing antibody targeting a conserved region of the prefusion RSV F protein.

Respiratory syncytial virus (RSV) poses a significant public health challenge, especially among children. Although palivizumab and nirsevimab, neutralizing antibodies (nAbs) targeting the RSV F protein, have been used for prophylaxis, their limitations underscore the need for more effective alternatives. Herein, we present a potent and broad nAb, named 5B11, which exhibits nanogram level of unbiased neutralizing activities against both RSV-A and -B subgroups.

Role of ADAM10/17-Mediated Cleavage of LAG3 in the Impairment of Immunosuppression in Psoriasis.

Despite extensive research on immune activation regulatory mechanisms, studies on immune suppression in psoriasis are limited. LAG3, a newly identified immune checkpoint, plays a crucial role in modulating immune responses and maintaining T-regulatory cell function. However, its involvement in psoriasis is unclear.

Optimization of SHP2 allosteric inhibitors with novel tail heterocycles and their potential as antitumor therapeutics.

SHP2, a non-receptor protein tyrosine phosphatase involved in cancers, plays a pivotal role in numerous cellular signaling cascades, including the MAPK and PD-L1/PD-1 pathways. Although several SHP2 allosteric inhibitors have already entered clinical trials, none have been approved to date. Therefore, the development of new SHP2 allosteric inhibitors with improved efficacy is urgently required.

The ultimate microbial composition for correcting Th17/Treg cell imbalance and lipid metabolism disorders in osteoporosis.

Osteoporosis is a systemic bone disease characterised by decreased bone mass and a deteriorated bone microstructure, leading to increased bone fragility and fracture risk. Disorders of the intestinal microbiota may be key inducers of osteoporosis. Furthermore, such disorders may contribute to osteoporosis by influencing immune function and lipid metabolism.

Association between dietary niacin intake and chronic obstructive pulmonary disease among American middle-aged and older individuals: A cross-section study.

Background: The attention towards the relationship between chronic obstructive pulmonary disease (COPD) and dietary intake is escalating. However, the effects of dietary niacin on COPD in middle and older individuals remains unclear. This study aimed to illuminate the connection between dietary niacin intake and COPD.

Debate on the relationship between infection and inflammatory bowel disease: a bibliometric analysis.

Background: Inflammatory bowel diseases (IBD) are chronic inflammation conditions affecting the gastrointestinal tract. Studies point out an association between () infection and IBD. This study aims to visually assess the research trends and hotspots in the field of infection and IBD, review mainstream perspectives in this field, and provide a foundation for future research and treatment.

Key factors influencing sustainable population growth: A DEMATEL-ANP combined approach.

This study highlights the importance of sustainable social demographic growth. It uses a model that combines the Decision-making Trial and Evaluation Laboratory (DEMATEL) with the Analytic Network Process (ANP) to examine key factors affecting this growth and their interactions. The analysis focuses on six critical factors: economic development, education and gender equality, health services, environmental sustainability, immigration policies, and technological advancement.

A pH-triggered self-releasing humic acid hydrogel loaded with porcine interferon α/γ achieves anti-pseudorabies virus effects by oral administration.

Interferon α (IFNα) and interferon γ (IFNγ) play pivotal roles in mediating crucial biological functions, including antiviral activity and immune regulation. However, the efficacy of monomeric IFN is limited, and its administration relies solely on injection. To address this issue, we successfully expressed and purified a recombinant porcine IFNα and IFNγ fusion protein (rPoIFNα/γ).

Ordered assemblies of peptide nanoparticles with only positive charge.

Surface charge patchiness of different charge types can influence the solution behaviours of colloidal particles and globular proteins. Herein, coiled-coil 'bundlemer' nanoparticles that display only a single type of surface charge (SC) are computationally designed to compare their solution behaviours to mixed charge-type (MC) counterparts with both positively and negatively charged side chains. Nematic and columnar liquid crystal phases are discovered in low concentrations of SC particles, indicative of particle end-to-end stacking into columns combined with lateral electrostatic repulsion between columns, while MC particles with the same net charge and particle shape produced only amorphous, soluble aggregates.

Plasma metabolite profiles related to dietary patterns: exploring the association with colorectal tumor risk.

Background: Multiple diet patterns play a crucial role in the development of colorectal cancer and its precursor, colorectal adenoma, but mediating effect of plasma metabolite profiles is unclear.

Methods: A total of 95,275 participants from UK Biobank with plasma metabolomics and dietary information were analyzed. Metabolite profile scores for 14 dietary patterns were estimated through elastic net regression.

Regulating Room-Temperature Phosphorescence of Organic Luminophores Through Stepwise Stabilization by Coordination and In-Situ Precipitation Reaction.

Developing efficiency and long-lived room-temperature phosphorescence (RTP) materials through straightforward methods is highly desired. In this work, a stepwise stabilization strategy was proposed by the coordination and in-situ precipitation reactions among organic precursors, inorganic cation and anions, producing room-temperature phosphorescence materials with high emission efficiency (phosphorescence quantum yield of 45 %). Structural and photophysical characterizations revealed the coordination reaction reduced the energy gaps between singlet and triplet states and stabilized the excited states of the guest molecules.

Identification and characterization of 16 tripartite motif-containing proteins from Takifugu obscurus.

Tripartite motif-containing (TRIM) proteins play important roles in apoptosis, development, autophagy, and innate immunity in vertebrates. In this study, a total of 16 TRIM genes were cloned and identified from obscure puffer Takifugu obscurus. Multiple alignment results showed that most of the deduced ToTRIM proteins contained three typical motifs, a really interesting new gene (RING) zinc-finger domain, one B-box, and a coiled-coil domain, which together formed the TRIM motif found in this large family of proteins.

Residential blue space, cognitive function, and the role of air pollution in middle-aged and older adults: A cross-sectional study based on UK biobank.

This study examines the relationship between residential exposure to blue spaces (e.g., rivers, lakes, and seas) and cognitive function in middle-aged and older adults in the United Kingdom, with a specific focus on the mediating effects of air pollution, particularly nitrogen dioxide (NO₂) and fine particulate matter (PM).

Glycomic profiling of parathyroid neoplasms via lectin microarray analysis.

Purpose: Parathyroid carcinoma (PC) is a rare malignancy with a poor prognosis. Diagnosis of PC is often difficult in clinical practice and efficient diagnostic markers are still needed for differential diagnosis. Aberrant glycosylations of glycoproteins were identified with lectin microarray in various cancers, while relevant information is lacking in PC.

Alternative polyadenylation landscape of longissimus dorsi muscle with high and low intramuscular fat content in cattle.

Intramuscular fat content is one of the most important factors affecting beef quality. However, the role of alternative polyadenylation (APA) in intramuscular fat deposition remains unclear. We compared APA events in muscle samples from high and low intramuscular fat (IMF) cattle, based on RNA-seq data.