Deamidation analysis of therapeutic drugs using matrix-assisted laser desorption ionization mass spectrometry and a novel algorithm QuanDA.

A robust deamidation quantification method, called QuanDA, was developed to quantify the spontaneous nonenzymatic deamidation of peptides based on the isotopic distribution change of peptides in matrix-assisted laser desorption ionization (MALDI) mass spectra and non-negative least squares calculation. The predictive model of QuanDA using theoretical spectra of pure un-deamidated and deamidated peptides for a series of simulated partial deamidated peptides is satisfying, with a coefficient of determination () and root mean squared error (RMSE) of 0.9914 and 0.

A hybrid sparrow optimization Kriging model and its application in geological modeling.

With the proposal of intelligent mines, the demand for drilling is increasing daily. Therefore, it is particularly crucial to gather more geological data by interpolation of limited drilling data for subsequent three-dimensional geological modeling. In this paper, a hybrid sparrow optimization Kriging model (HSSA), in which chaos theory and Levy flight are integrated into the initial population update algorithm of the sparrow algorithm and the location update algorithm of the entrants, is proposed.

Understanding the mechanism of gully erosion in the alpine region through an interpretable machine learning approach.

In the alpine region, climate warming has led to the retreat of glaciers, snow cover, and permafrost. This has intensified water cycling, soil erosion, and increased the occurrence of natural disasters in the alpine region. This study investigated the Lhasa River Basin in the southern Tibetan Plateau, serving as a representative case study of a typical alpine basin, with a specific focus on gully erosion.

Preparation and Rheological Properties of the PVA/CMC/Gel Composite for Mining.

A composite gel material with an interpenetrating network structure was formed using the chemical cross-linking method. The viscosity, yield stress, and thixotropy of a poly(vinyl alcohol)/carboxymethyl cellulose/gelatin (PVA/CMC/Gel) composite gel slurry with different ratios were tested using a viscometer, and the interaction between the surface of the gelling agent and the cross-linking agent was analyzed by calculating the frontline orbital energy of a single polymer material molecule. The seepage diffusion characteristics of the composite gel in a goaf were then studied through a numerical simulation.

Pomiferin targeting SLC9A9 based on histone acetylation modification pattern is a potential therapeutical option for gastric cancer with high malignancy.

Changes in histone acetylation status are associated with gastric cancer (GC) progression. Pomiferin is a natural flavonoid, however, the specific role of pomiferin in the treatment of GC is still unclear, and its targets are not well clarified. In this work, the prognostic genes related with histone acetylation in GC were screened by univariate Cox analysis.

Development and validation of an MRI-Based nomogram to predict the effectiveness of immunotherapy for brain metastasis in patients with non-small cell lung cancer.

Introduction: The variability and unpredictability of immune checkpoint inhibitors (ICIs) in treating brain metastases (BMs) in patients with advanced non-small cell lung cancer (NSCLC) is the main concern. We assessed the utility of novel imaging biomarkers (radiomics) for discerning patients with NSCLC and BMs who would derive advantages from ICIs treatment.

Methods: Data clinical outcomes and pretreatment magnetic resonance images (MRI) were collected on patients with NSCLC with BMs treated with ICIs between June 2019 and June 2022 and divided into training and test sets.

Using MRI radiomics to predict the efficacy of immunotherapy for brain metastasis in patients with small cell lung cancer.

Background: Brain metastases (BMs) are common in small cell lung cancer (SCLC), and the efficacy of immune checkpoint inhibitors (ICIs) in these patients is uncertain. In this study we aimed to develop and validate a radiomics nomogram based on magnetic resonance imaging (MRI) for intracranial efficacy prediction of ICIs in patients with BMs from SCLC.

Methods: The training and validation cohorts consisted of 101 patients from two centers.

Noninvasive radiomic biomarkers for predicting pseudoprogression and hyperprogression in patients with non-small cell lung cancer treated with immune checkpoint inhibition.

This study aimed to develop a computed tomography (CT)-based radiomics model capable of precisely predicting hyperprogression and pseudoprogression (PP) in patients with non-small cell lung cancer (NSCLC) treated with immunotherapy. We retrospectively analyzed 105 patients with NSCLC, from three institutions, treated with immune checkpoint inhibitors (ICIs) and categorized them into training and independent testing set. Subsequently, we processed CT scans with a series of image-preprocessing techniques, and 6008 radiomic features capturing intra- and peritumoral texture patterns were extracted.

Strategies for Preventing Esophageal Stenosis After Endoscopic Submucosal Dissection and Progress in Stem Cell-Based Therapies.

Endoscopic submucosal dissection (ESD) has been widely used in the early neoplasia of the esophagus. However, postoperative esophageal stenosis is a big problem, particularly when a large circumferential proportion of esophageal mucosa is resected. Currently, there are several methods available to prevent esophageal stenosis after ESD, including steroid administration, esophageal stent implantation, and endoscopic balloon dilation (EBD).

A retrospective pilot study of transarterial chemoembolisation using camrelizumab-eluting Callisphere beads for unresectable hepatocellular carcinoma.

Background: Our objective was to assess the efficacy and safety of initial hepatic arterial infusion of chemotherapy combined with transarterial chemoembolisation using camrelizumab-eluting Callisphere beads (camrelizumab-DEB-TACE) for treating unresectable hepatocellular carcinoma (HCC).

Methods: Enrolment included patients with unresectable HCC who underwent camrelizumab-DEB-TACE treatment from September 2021 to February 2023. The assessment included the examination of tumour response, overall survival (OS), progression-free survival (PFS), and the monitoring of adverse events (AEs).

A century-long record of polycyclic aromatic hydrocarbon deposition in the Old Yellow River Estuary, China.

Polycyclic aromatic hydrocarbons (PAHs) are potential geochemical indicators for assessing the impact of human activities and can be used to reconstruct historical human activities. This study collected a 108 cm sediment core from the 5th lobe of the Yellow River Delta for the first time and analyzed the historical distribution characteristics of PAHs in this area. The results showed that the sedimentation history of the core was from 1908 to 2014.

Niche differentiation and influencing factors of nitrite oxidation bacteria Nitrospira in sediments of the Luan River estuary in China.

In the estuarine sediment, the nitrite oxidation process mediated by bacteria significantly influences nitrification. Nitrospira is the most widely distributed nitrite-oxidizing bacteria (NOB) and can adapt to various environments. In this study, the Nitrospira-specific primer nxrB 169F-638R was used to analyze the microbial communities in the sediments of low-, middle-, and high-level zones in the Luan River estuary.

Local injection of adipose-derived mesenchymal stem cells in silk fibroin solution on the regeneration of lower esophageal sphincter in an animal model of GERD.

Presently, various tissue engineering methods using adult stem cells and biomaterials are being confirmed to regenerate vessels, cardiac muscle, bladder, and intestines. However, there are few studies about the repair of the lower esophageal sphincter (LES) may help alleviate the symptoms of gastroesophageal reflux disease (GERD). This study aims to determine whether Adipose-Derived Stem Cells (ADSCs) combined with regenerated silk fibroin (RSF) solution could regenerate the LES.

Spatial Distribution Pattern Evolution of the Population and Economy in Russia since the 21st Century.

Under the background of "the Belt and Road" and "China, Mongolia and Russia economic corridor" initiatives, this paper studied the spatial distribution pattern evolution of population and economy in Russia since the 21st century, which could provide implications for the regional development planning, economic optimization layout, energy resource development, transportation infrastructure construction between China and Russia. Combined with the panel data of population, GDP, land area, etc., we used the gravity center analysis, geographic concentration degree, and inconsistency index to study Russia's population pattern evolution trend, economic pattern evolution trend, spatial inconsistency types of population distribution and economic development.

Cuproptosis-Related LncRNA Signature for Predicting Prognosis of Hepatocellular Carcinoma: A Comprehensive Analysis.

Hepatocellular carcinoma (HCC) is one of the most common malignant tumors worldwide and has a poor prognosis. Cuproptosis is a novel mode of cell death that has only recently been discovered. Considering the critical role of lncRNAs in liver cancer development, the aim of this study was to construct a prognostic signature based on cuproptosis-related lncRNAs (CRlncRNAs).

Sila-spirocyclization involving unstrained C(sp)-Si bond cleavage.

C - Si Bond cleavage is one of the key elemental steps for a wide variety of silicon-based transformations. However, the cleavage of unstrained Si-C(sp) bonds catalyzed by transition metal are still in their infancy. They generally involve the insertion of a M - C(sp) species into the C - Si bond and consequent intramolecular C(sp)‒Si coupling to exclusively produce siloles.

Transarterial chemoembolization of unresectable renal cell carcinoma with doxorubicin-loaded CalliSpheres drug-eluting beads.

The safety and efficacy of drug-eluting beads transarterial chemoembolization (DEB-TACE) for unresectable renal cell carcinoma (RCC) still unknown. We aimed to assess the feasibility, safety and clinical efficacy of DEB-TACE with doxorubicin-loaded CalliSpheres beads (CB) in patients with unresectable RCC. Between 2016 and 2020, thirty-five patients with unresectable RCC underwent DEB-TACE with doxorubicin-loaded CB.

Drug-Eluting Embolics Chemoembolization for the Management of Recurrent or Advanced Head and Neck Cancer.

Purpose: To characterize the safety, tolerability, and efficacy of chemoembolization using drug-eluting embolic (DEE) microspheres in patients with recurrent and advanced head and neck cancer.

Materials And Methods: In this retrospective study, 32 patients (mean age, 57.2 years ± 2.

Arsenic Release from Soil Induced by Microorganisms and Environmental Factors.

In rhizospheric soil, arsenic can be activated by both biological and abiotic reactions with plant exudates or phosphates, but little is known about the relative contributions of these two pathways. The effects of microorganisms, low-molecular-weight organic acid salts (LMWOASs), and phosphates on the migration of As in unrestored and nano zero-valent iron (nZVI)-restored soil were studied in batch experiments. The results show that As released by microbial action accounted for 17.

A Hemolysis Image Detection Method Based on GAN-CNN-ELM.

Since manual hemolysis test methods are given priority with practical experience and its cost is high, the characteristics of hemolysis images are studied. A hemolysis image detection method based on generative adversarial networks (GANs) and convolutional neural networks (CNNs) with extreme learning machine (ELM) is proposed. First, the image enhancement and data enhancement are performed on a sample set, and GAN is used to expand the sample data volume.

Clinical outcomes of uterine arterial chemoembolization with drug-eluting beads for advanced-stage or recurrent cervical cancer.

Purpose: To study the clinical efficacy and safety of transarterial chemoembolization with drug-eluting beads (DEB-TACE) among women with advanced-stage or recurrent cervical cancer.

Methods: This retrospective cohort study enrolled women with cervical cancer who were treated by DEB-TACE between April 3, 2017 and July 12, 2021. Inclusion criteria were pathologic diagnosis of cervical cancer, II-IVa period, being aged 18 to 80 years, patient's inclination of treatment with DEB-TACE, and complete clinicopathologic data.