Dissecting the effects of co-exposure to microplastics and sulfamethoxazole on anaerobic digestion.

Microplastics (MPs) and antibiotics are frequently and simultaneously detected in sewage and sludge, raising global concerns in recent years. However, their combined effects on anaerobic digestion (AD) remain unclear. Herein, we evaluated the effects of the combinations of different MPs (i.

Gut microbiota-mediated hsa_circ_0126925 targets BCAA metabolic enzyme BCAT2 to exacerbate colorectal cancer progression.

Recent evidence indicates that a high-fat diet (HFD) can promote tumor development, especially colorectal cancer (CRC), by influencing the microbiota. Regulatory circular RNAs (circRNAs) play an important role in modulating host-microbe interactions; however, the specific mechanisms by which circRNAs influence cancer progression by regulating these interactions remain unclear. Here, we report that consumption of a HFD modulates the microbiota by specifically upregulating the expression of the noncoding RNA hsa_circ_0126925 (herein referred to as circ_0126925) in CRC.

Bistable Soft Shells for Programmable Mechanical Logic.

Mechanical computing promises to integrate semiconductor-based digital logic in several applications, but it needs straightforward programmable devices for changing computing rules in situ. A methodology based on strain-governed, bistable soft shells that process digital information by interchanging their internal/external surfaces is proposed. This bistable behavior, explained via model-based design, safeguards robustness by working only once for each input pulse.

An integrative TAD catalog in lymphoblastoid cell lines discloses the functional impact of deletions and insertions in human genomes.

The human genome is packaged within a three-dimensional (3D) nucleus and organized into structural units known as compartments, topologically associating domains (TADs), and loops. TAD boundaries, separating adjacent TADs, have been found to be well conserved across mammalian species and more evolutionarily constrained than TADs themselves. Recent studies show that structural variants (SVs) can modify 3D genomes through the disruption of TADs, which play an essential role in insulating genes from outside regulatory elements' aberrant regulation.

A processable and recyclable gelatin/carboxymethyl chitosan hydrogel electrolyte for high performance flexible zinc-ion batteries.

Hydrogels are currently under extensive research as flexible quasi-solid electrolytes for zinc-ion batteries. However, the non-degradability and non-recyclability of hydrogel electrolytes pose significant issues, leading to resource wastage and plastic pollution. Moreover, the increasing needs of hydrogel electrolyte with various shapes to meet individual requirements of next-generation flexible battery raise significant challenges.

Inhibition of XIST restrains paclitaxel resistance in breast cancer cells by targeting hsa-let-7d-5p/ATG16L1 through regulation of autophagy.

Breast cancer is a fatal malignant tumor in women worldwide. The development of paclitaxel resistance remains a challenge. Autophagy is considered to have a significant part in the chemotherapeutic stress mechanism.

Wavelength-specific inactivation mechanisms and efficacies of germicidal UVC for airborne human coronavirus.

Ultraviolet germicidal irradiation (UVGI) technology can inhibit the environmental transmission of airborne pathogens, but the dose-response behavior of airborne human coronavirus and wavelength-specific inactivation mechanisms are not well understood. This study investigated three competitive UVC sources for their inactivation efficacy and mechanisms against human coronavirus OC43 (HCoV-OC43). Results showed the following order of inactivation efficacy: 222-nm KrCl excimer lamp > 263-nm UV-LEDs > 254-nm low-pressure mercury lamp.

Metagenomic insights into the rapid recovery mechanisms of prokaryotic community and spread of antibiotic resistance genes after seawater disinfection.

Disinfectants, such as bleaching powder, are widely employed in marine aquaculture worldwide to control the bacterial pathogens and eliminate antibiotic resistance genes (ARGs). Nevertheless, the rapid recovery of prokaryotic community compositions (PCCs) after disinfection may significantly influence the overall efficacy of disinfection. Presently, little is known about the rapid recovery mechanisms of PCCs and its impact on the removal of ARGs in seawater.

Room-temperature exceptional plasticity in defective BiTe-based bulk thermoelectric crystals.

The recently discovered metal-like room-temperature plasticity in inorganic semiconductors reshapes our knowledge of the physical properties of materials, giving birth to a series of new-concept functional materials. However, current room-temperature plastic inorganic semiconductors are still very rare, and their performance is inferior to that of classic brittle semiconductors. Taking classic bismuth telluride (BiTe)-based thermoelectric semiconductors as an example, we show that antisite defects can lead to high-density, diverse microstructures that substantially affect mechanical properties and thus successfully transform these bulk semiconductors from brittle to plastic, leading to a high figure of merit of up to 1.

Impact of Nuclear Peripheral Chromatin Lamin LMNB1 Gene in the Proliferation and Migration of Glioma Cells.

The goal of this study is to explore the role of the LMNB1 gene in glioma. A cohort of 160 patients who underwent glioma surgery were randomly selected of this study. The LMNB1 expression was assessed employing immunohistochemical and real-time quantitative polymerase chain reaction methods.

[Retracted] Hypoxia‑induced overexpression of DEC1 is regulated by HIF‑1α in hepatocellular carcinoma.

Further to the publication of the above paper, a concerned reader drew to our attention that, in Figs. 1A and 4A, the same loading controls for the RT‑PCR experiments portrayed had apparently been incorporated into these figures, even though the experimental results (i.e.

Enhanced inverse Faraday effect and time-dependent thermo-transmission in gold nanodisks.

Nonmagnetic media can be magnetized by light via processes referred to as an inverse Faraday effect (IFE). With nonmagnetic metal nanostructures, the IFE is dominated by the presence of light-induced solenoidal surface currents or plasmons with orbital angular momenta, whose properties depend on both the light and nanostructure geometry. Here, through a systematic study of gold nanodisks with different sizes, we demonstrate order-of-magnitude enhancement of the IFE compared to a bare gold film.

Predicting allergen immunotherapy efficacy based on early maintenance phase response in routine clinical practice.

Background: While allergen-specific immunotherapy (AIT) is acknowledged as an effective treatment, its efficacy varies, and consensus on predictive indicators for AIT responders remains elusive.

Objective: This study aimed to identify alternative parameters for predicting AIT responders based on clinical data collected in daily practice.

Method: We conducted a retrospective analysis of patients with house-dust-mite-driven asthma and/or rhinitis who completed 3 years of subcutaneous AIT (3y-AIT).

18F-AlF-NOTA-octreotide PET/CT and 3D printing technology for precision diagnosis and treatment of phosphaturic mesenchymal tumors in patients with tumor-induced osteomalacia: two case reports.

Objective: This study aims to report the application of 18F-AlF-NOTA-Octreotide PET/CT and 3D printing technology in the diagnosis and treatment of phosphaturic mesenchymal tumors (PMT) in patients with tumor-induced osteomalacia (TIO).

Case Presentation: A 68-year-old male patient (Case 1) was admitted to the Weifang People's Hospital in August 2022 with complaints of "persistent pain in the bilateral flank and lumbosacral region". 18F-AlF-NOTA-Octreotide PET/CT showed high octreotide expression in the left femoral region.

Exploring distinct modes of inter-spike cross-linking for enhanced neutralization by SARS-CoV-2 antibodies.

The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and its Omicron subvariants drastically amplifies transmissibility, infectivity, and immune escape, mainly due to their resistance to most neutralizing antibodies. Thus, exploring the mechanisms underlying antibody evasion is crucial. Although the full-length native form of antibody, immunoglobulin G (IgG), offers valuable insights into the neutralization, structural investigations primarily focus on the fragment of antigen-binding (Fab).

A viral protein activates the MAPK pathway to promote viral infection by downregulating callose deposition in plants.

Mitogen-activated protein kinase (MAPK) cascades are evolutionarily conserved in both plants and animals and play critical roles in activating innate immunity to defend against various pathogens. However, the role of MAPK cascades in positively regulating or enhancing viral infections in plants is unclear. In this study, we investigate the involvement of MAPK cascades in infection by the positive-strand RNA virus tomato chlorosis virus (ToCV).

Maintenance of Cardiac Microenvironmental Homeostasis: A Joint Battle of Multiple Cells.

Various cells such as cardiomyocytes, fibroblasts and endothelial cells constitute integral components of cardiac tissue. The health and stability of cardiac ecosystem are ensured by the action of a certain type of cell and the intricate interactions between multiple cell types. The dysfunctional cells exert a profound impact on the development of cardiovascular diseases by involving in the pathological process.

[Optical Characteristics and Source Analysis of Dissolved Organic Matter in Hypersaline Lakes in Cold and Arid Regions].

The composition and source information of the aquatic dissolved organic matter （DOM） in the Daihai Lake, a typical saline lake at the ecologically fragile agro-pastoral area, were explored with three-dimensional excitation and emission matrix fluorescence （3DEEM）, parallel factor analysis （PARAFAC）, and fluorescence peaks （B, T, A, M, C, D, and N）. Further, the relationship between aquatic DOM fluorescence characteristics and environmental factors were analyzed using correlation analysis in the Daihai Lake. The results showed that the water of Daihai was weakly alkaline, with high nutrient salt concentration and serious organic pollution.

[Comprehensive Eutrophication Evaluation and Water Environment Capacity Analysis of Yiwu Yankou Reservoir].

The accumulation of excessive nitrogen, phosphorus, and other nutrients in rivers, lakes, and reservoirs has greatly accelerated eutrophication, which has led to the frequent outbreaks of algal blooms and brought great ecological risks to the related aquatic ecosystems. Evaluations on the eutrophic status of water bodies and estimations of water environment capacity are not only crucial for comprehensive assessment of eutrophic status but also indispensable references for comprehensive management of the aquatic ecosystems. In this study, major environmental variables （chemical oxygen demand, total nitrogen, and total phosphorus） of Yankou Reservoir watershed were monitored monthly from May 2020 to March 2022 and based upon the determined results, the comprehensive eutrophic conditions and water environment capacity were evaluated and estimated.

[Land Use Changes and Its Impact on Ecological Environment Quality in Bayannur City].

As an important ecological protective screen in northern China, monitoring and evaluating the dynamic changes in habitat quality and their relationship with land use changes in Bayannur played a notable role in maintaining regional ecological balance and species diversity. Based on the Google earth engine （GEE） platform, this study employed multi-period remote sensing image coupling to construct a remote sensing ecological index （RSEI）, analyzed the changes in habitat quality in Bayannur City from 2000 to 2022, and explored its relationship with land use changes. The results showed that： ① From 2000 to 2022, although the habitat quality of Bayannur improved slowly, the overall quality was poor.

Role and mechanism of myonectin in severe acute pancreatitis: a crosstalk between skeletal muscle and pancreas.

Background: Severe acute pancreatitis (SAP) is characterized by high mortality rates and various complications, including skeletal muscle atrophy, which significantly exacerbates its outcomes. Despite its clinical relevance, the mechanistic understanding of the relationship between skeletal muscle and the pancreas in SAP remains limited. Our study aimed to elucidate this "organ crosstalk" and its potential implications.