An Ultramicroporous Physisorbent Sustained by a Trifecta of Directional Supramolecular Interactions.

2D and 3D porous coordination networks (PCNs) as exemplified by metal-organic frameworks, MOFs, have garnered interest for their potential utility as sorbents for molecular separations and storage. The inherent modularity of PCNs has enabled the development of crystal engineering strategies for systematic fine-tuning of pore size and chemistry in families of related PCNs. The same cannot be said about one-dimensional (1D) coordination polymers, CPs, which are understudied with respect to porosity.

Water sorption performance of the zeolitic metal azolate framework MAF-7.

Water sorption isotherms of [Zn(mtz)] (MAF-7) were collected over a wide temperature range (15-45 °C) and its water sorption performance was assessed in terms of water uptake, sorption kinetics, recyclability, and regeneration temperature. Additionally, molecular simulations were conducted to elucidate the locations of water molecules within the pore cavity of MAF-7.

β-adrenergic regulation of Ca signaling in heart cells.

β-adrenergic receptors (βARs) play significant roles in regulating Ca signaling in cardiac myocytes, thus holding a key function in modulating heart performance. βARs regulate the influx of extracellular Ca and the release and uptake of Ca from the sarcoplasmic reticulum (SR) by activating key components such as L-type calcium channels (LTCCs), ryanodine receptors (RyRs) and phospholamban (PLN), mediated by the phosphorylation actions by protein kinase A (PKA). In cardiac myocytes, the presence of βAR provides a protective mechanism against potential overstimulation of βAR, which may aid in the restoration of cardiac dysfunctions.

Designing Heterocyclic Covalent Organic Frameworks with Tunable Electronic Structures for Efficient Electrosynthesis of Hydrogen Peroxide.

The electrocatalytic production of hydrogen peroxide (HO) through the two-electron oxygen reduction reaction (2e ORR) has garnered significant research attention in recent years due to its numerous appealing advantages, such as being eco-friendly and exhibiting high energy conversion efficiency. Metal-free carbon materials with specific catalytic sites have been recognized as potential electrocatalysts for 2e ORR; however, the design of highly efficient catalysts with well-defined structures and long-term stability for large-scale HO production remains unsatisfactory. In this study, three covalent organic frameworks (COFs) - imine-linked LZU-1, oxazole-linked LZU-190, and thiazole-linked LZU-190(S), are successfully synthesized to explore their catalytic activity in electrocatalytic HO production.

Gate-opening Induced by C8 Aromatics in a Double Diamondoid Coordination Network.

Coordination networks (CNs) that undergo guest-induced structural transformations are of topical interest thanks to their potential utility in separations and storage applications. Herein, we report a double diamondoid () topology CN, [Ni(bimpz)(bdc)(HO)] or (Hbdc = 1,4-benzenedicarboxylic acid, bimpz = 3,6-bis(imidazol-1-yl)pyridazine), that undergoes structural transformations induced by C8 isomers, i.e.

Effect of Polymorphism on the Sorption Properties of a Flexible Square-Lattice Topology Coordination Network.

The stimulus-responsive behavior of coordination networks (CNs), which switch between closed (nonporous) and open (porous) phases, is of interest because of its potential utility in gas storage and separation. Herein, we report two polymorphs of a new square-lattice () topology CN, , of formula [Cu(Imibz)] (HImibz = {[4-(1-imidazol-1-yl)phenylimino]methyl}benzoic acid), isolated from the as-synthesized CN , which subsequently transformed to a narrow pore solvate, , upon mild activation (drying in air or heating at 333 K under nitrogen). contains MeOH in cavities, which was removed through exposure to vacuum for 2 h, yielding the nonporous (closed) phase .

Insight into the Gas-Induced Phase Transformations in a 2D Switching Coordination Network via Coincident Gas Sorption and PXRD.

Switching coordination networks (CNs) that reversibly transform between narrow or closed pore (cp) and large pore (lp) phases, though fewer than their rigid counterparts, offer opportunities for sorption-related applications. However, their structural transformations and switching mechanisms remain underexplored at the molecular level. In this study, we conducted a systematic investigation into a 2D switching CN, [Ni(bpy)(NCS)], sql-1-Ni-NCS (1 = bpy = 4,4'-bipyridine), using coincident gas sorption and powder X-ray diffraction (PXRD) under low-temperature conditions.

Switching Adsorbent Layered Material that Enables Stepwise Capture of C Aromatics via Single-Crystal-to-Single-Crystal Transformations.

Separation of the C aromatic isomers, xylenes (PX, MX, and OX) and ethylbenzene (EB), is important to the petrochemical industry. Whereas physisorptive separation is an energy-efficient alternative to current processes, such as distillation, physisorbents do not generally exhibit strong C selectivity. Herein, we report the mixed-linker square lattice () coordination network [Zn(sba)(bis)]·DMF (, Hsba or = 4,4'-sulfonyldibenzoic acid, bis or = trans-4,4'-bis(1-imidazolyl)stilbene) and its C sorption properties.

Robust small molecule-aided cardiac reprogramming systems selective to cardiac fibroblasts.

Direct cardiac reprogramming to induce cardiomyocyte-like cells, e.g., by GMT (Gata4, Mef2c and Tbx5), is a promising route for regenerating damaged heart and disease modeling .

Shape-Memory Effect Enabled by Ligand Substitution and CO Affinity in a Flexible SIFSIX Coordination Network.

We report that linker ligand substitution involving just one atom induces a shape-memory effect in a flexible coordination network. Specifically, whereas SIFSIX-23-Cu, [Cu(SiF )(L) ] , (L=1,4-bis(1-imidazolyl)benzene, SiF =SIFSIX) has been previously reported to exhibit reversible switching between closed and open phases, the activated phase of SIFSIX-23-Cu , [Cu(SiF )(L ) ] (L =2,5-bis(1-imidazolyl)pyridine), transformed to a kinetically stable porous phase with strong affinity for CO . As-synthesized SIFSIX-23-Cu , α, transformed to less open, γ, and closed, β, phases during activation.

A live-cell image-based machine learning strategy for reducing variability in PSC differentiation systems.

The differentiation of pluripotent stem cells (PSCs) into diverse functional cell types provides a promising solution to support drug discovery, disease modeling, and regenerative medicine. However, functional cell differentiation is currently limited by the substantial line-to-line and batch-to-batch variabilities, which severely impede the progress of scientific research and the manufacturing of cell products. For instance, PSC-to-cardiomyocyte (CM) differentiation is vulnerable to inappropriate doses of CHIR99021 (CHIR) that are applied in the initial stage of mesoderm differentiation.

Control over Phase Transformations in a Family of Flexible Double Diamondoid Coordination Networks through Linker Ligand Substitution.

In this work, we present the first metal-organic framework (MOF) platform with a self-penetrated double diamondoid () topology that exhibits switching between closed (nonporous) and open (porous) phases induced by exposure to gases. A crystal engineering strategy, linker ligand substitution, was used to control gas sorption properties for CO and C3 gases. Specifically, bimbz (1,4-bis(imidazol-1-yl)benzene) in the coordination network ([Ni(bimbz)(bdc)(HO)], Hbdc = 1,4-benzenedicarboxylic acid) was replaced by bimpz (3,6-bis(imidazol-1-yl)pyridazine) in ([Ni(bimpz)(bdc)(HO)]).

Engineering of NEMO as calcium indicators with large dynamics and high sensitivity.

Genetically encoded calcium indicators (GECIs) are indispensable tools for real-time monitoring of intracellular calcium signals and cellular activities in living organisms. Current GECIs face the challenge of suboptimal peak signal-to-baseline ratio (SBR) with limited resolution for reporting subtle calcium transients. We report herein the development of a suite of calcium sensors, designated NEMO, with fast kinetics and wide dynamic ranges (>100-fold).

Pressure-Induced Structural Effects in the Square Lattice () Topology Coordination Network Sql-1-Co-NCS·4OX.

A high-pressure study of a switching coordination network of square lattice topology () loaded with -xylene (OX), [Co(4,4'-bipyridine)(NCS)] ·4nCH (sql-1-Co-NCS·4OX), was conducted up to approximately 1 GPa to investigate pressure-induced structural changes. Previous reports revealed that sql-1-Co-NCS exhibits multiple phases thanks to its ability to switch between closed (nonporous) and several open (porous) phases in the presence of various gases, vapors, and liquids. Networks of such properties are of topical interest because they can offer high working capacity and improved recyclability for gas adsorption.

Dosimetry comparison with helical tomotherapy, volumetric modulated arc therapy, and intensity-modulated radiotherapy for grade II gliomas: A single‑institution case series.

Radiotherapy is an essential postoperative treatment for grade II gliomas. However, comparative dosimetric studies of different radiotherapy plans for grade II gliomas are still lacking. Therefore, we conducted this case series analysis to compare the dosimetric differences among helical tomotherapy (TOMO), volumetric modulated arc therapy (VMAT), and intensity-modulated radiotherapy (IMRT) for grade II gliomas.

Adsorbate-dependent phase switching in the square lattice topology coordination network [Ni(4,4'-bipyridine)(NCS)].

Switching coordination networks (CNs) featuring stepped sorption isotherms that are accompanied by phase changes offer promise for gas storage and separation applications. However, their responsiveness to different adsorbates remains largely understudied. Herein, we report the variable switching behaviour of a previously known square lattice (sql) topology CN, [Ni(4,4'-bipyridine)(NCS)] (sql-1-Ni-NCS), with respect to nine gaseous adsorbates.

Magnetic 3d-4f Chiral Clusters Showing Multimetal Site Magneto-Chiral Dichroism.

Here, we report the molecular self-assembly of hydroxido-bridged {LnNi} ((Ln = Dy, Y) metal clusters by the reaction of enantiopure chiral ligands, namely, (/)-(2-hydroxy-3-methoxybenzyl)-serine), with Ni and Ln precursors. Single-crystal diffraction analysis reveals that these compounds are isostructural sandwich-like 3d-4f heterometallic clusters showing helical chirality. Direct current magnetic measurements on {DyNi} indicates ferromagnetic coupling between Dy and Ni centers, whereas those on {YNi} denote that the Ni centers are antiferromagnetically coupled and/or magnetically anisotropic.

Novel CaMKII-δ Inhibitor Hesperadin Exerts Dual Functions to Ameliorate Cardiac Ischemia/Reperfusion Injury and Inhibit Tumor Growth.

Background: Cardiac ischemia/reperfusion (I/R) injury has emerged as an important therapeutic target for ischemic heart disease, the leading cause of morbidity and mortality worldwide. At present, there is no effective therapy for reducing cardiac I/R injury. CaMKII (Ca/calmodulin-dependent kinase II) plays a pivotal role in the pathogenesis of severe heart conditions, including I/R injury.

Predicting potential distribution of (Bunge) H.H. Hu ex F.H. Chen in China under climate change scenarios.

(Bunge) H.H. Hu ex F.

Mutations and clinical significance of calcium voltage-gated channel subunit alpha 1E (CACNA1E) in non-small cell lung cancer.

CACNA1E is a gene encoding the ion-conducting α1 subunit of R-type voltage-dependent calcium channels, whose roles in tumorigenesis remain to be determined. We previously showed that CACNA1E was significantly mutated in patients with non-small cell lung cancer (NSCLC) who were long-term exposed to household air pollution, with a mutation rate of 19% (15 of 79 cases). Here we showed that CACNA1E was also mutated in 207 (12.