Dynamic human exposure to airborne bacteria-associated antibiotic resistomes revealed by longitudinal personal monitoring data.

Airborne antibiotic-resistant bacteria (ARB) can critically impact human health. We performed resistome profiling of 283 personal airborne exposure samples from 15 participants spanning 890 days and 66 locations. We found a greater diversity and abundance of airborne bacteria community and antibiotic resistomes in spring than in winter, and temperature contributed largely to the difference.

Safety and immunogenicity of a bivalent HPV16/18 vaccine in Chinese females.

As global supply is still inadequate to address the worldwide requirements for HPV vaccines, we assessed the safety and immunogenicity of a new bivalent HPV16/18 vaccine. In this randomized, double-blind, placebo-controlled, phase 2 trial, healthy 9-45-year-old Chinese females in three age cohorts (600 aged 9-17 years; 240 aged 18-26 years; 360 aged 27-45 years) were randomized 1:1 to receive three doses (0,2,6 months) of HPV16/18 vaccine or placebo. We measured neutralizing antibodies against HPV 16 and 18 at 7 months and monitored safety to 12 months in all age cohorts; 9-17-year-old girls were monitored for safety and immunogenicity to 48 months.

Safety and immunogenicity of a pichia pastoris-expressed bivalent human papillomavirus (types 16 and 18) L1 virus-like particle vaccine in healthy Chinese women aged 9-45 years: A randomized, double-blind, placebo-controlled phase 1 clinical trial.

Background: We evaluated the safety and immunogenicity of high and low doses of a novel pichia pastoris-expressed bivalent (types 16 and 18) human papillomavirus (HPV) virus-like particle vaccine.

Methods: In this randomized, double-blind, placebo-controlled phase 1 trial, we enrolled 160 healthy females aged 9-45 years in Guangxi, China who were randomized (1:1:2) to receive either low (0.5 mL) or high (1.

Current-Induced Spin Photocurrent in GaAs at Room Temperature.

Circularly polarized photocurrent, observed in p-doped bulk GaAs, varies nonlinearly with the applied bias voltage at room temperature. It has been explored that this phenomenon arises from the current-induced spin polarization in GaAs. In addition, we found that the current-induced spin polarization direction of p-doped bulk GaAs grown in the (001) direction lies in the sample plane and is perpendicular to the applied electric field, which is the same as that in GaAs quantum well.

Dietary Acid Load and the Risk of Pancreatic Cancer: A Prospective Cohort Study.

Background: Modern Western diets are rich in acidogenic foods. Human and studies suggest a potential link between dietary acid load and cancer risk. However, no epidemiologic studies have investigated the association of dietary acid load with the risk of pancreatic cancer.

Overexpression of Rab40b Promotes Hepatocellular Carcinoma Cell Proliferation and Metastasis via PI3K/AKT Signaling Pathway.

Background: Rab40b is an evolutionarily conserved Rab GTPase that plays an important role in intracellular trafficking and is closely related to cancer progression. However, the role and potential molecular mechanism of Rab40b in hepatocellular carcinoma (HCC) have not yet been elucidated.

Materials And Methods: The expression of Rab40b in HCC tissues and peritumour tissues was tested by qRT-PCR, Western blotting and histological analysis.

Least-squares ray mapping method for freeform illumination optics design.

Computing a source-target map that yields integrable surface normal field is quite challenging for freeform illumination design. Here, we propose a least-squares ray mapping method to calculate a superior ray mapping by iteratively correcting an integrable map to approach the energy conservation and boundary condition. The process is implemented via solving three minimization problems.

Sheng Mai San protects H9C2 cells against hyperglycemia-induced apoptosis.

Background: Sheng Mai San (SMS) has been proven to exhibit cardio-protective effects. This study aimed to explore the molecular mechanisms of SMS on hyperglycaemia (HG)-induced apoptosis in H9C2 cells.

Methods: HG-induced H9C2 cells were established as the experimental model, and then treated with SMS at 25, 50, and 100 μg/mL.

Double freeform surfaces design for beam shaping with non-planar wavefront using an integrable ray mapping method.

We propose a method to design double smooth freeform surfaces applied in beam shaping with a ray mapping method in the paper. We couple the calculation of ray mapping and the construction of freeform surfaces to approach the surface normal field integrability condition based on the symplectic flow mapping scheme. In this paper, the incident beam wavefront is not limited to be planar or spherical.

Multi-surface catadioptric freeform lens design for ultra-efficient off-axis road illumination.

We propose a novel design methodology to tackle the multi-surface catadioptric freeform lens design for off-axis road illumination applications based on an ideal source. The lens configuration contains an analytic refractive entrance surface, an analytic total internal reflective (TIR) surface and two freeform exit surfaces. A curl-free energy equipartition is established between the source and target plane and applied to implement the composite ray mapping mechanism.

Design of a head-up display based on freeform reflective systems for automotive applications.

Automotive head-up display (HUD), a typical application in augmented reality (AR), has gained popularity in recent years. In this paper, we propose a novel design configuration of freeform off-axis three-mirror systems for automotive head-up display (HUD) application. In the configuration, the image source, the flat mirror, and the freeform mirror are allocated on the same horizontal level to guarantee a compact structure as well as to make the optical elements easy to be assembled.

[Effect of Electroacupuncture and Manual Acupuncture on Colonic Inflammatory Injury, Cytokine Levels and Cell Apoptosis in Ulcerative Colitis Rats].

Objective: To observe the effect of electroacupuncture (EA) and manual acupuncture interventions on colonic inflammatory injury, cytokine level and cell apoptosis in ulcerative colitis (UC)rats, so as to reveal its mechanisms underlying improvement of UC.

Methods: A total of 32 SD rats were randomized into control, model, EA and manual acupuncture groups (8 rats/group). The UC model was established by intrarectally administration of 5% trinitro-benzene-sulfonic acid (TNBS)+ dehydrated alcohol.

[Distribution and expression of TGF-ß2 in the capsule of children with developmental dysplasia of the hip].

Objective: This study examined the distribution and expression of transforming growth factor-ß₂ (TGF-ß₂) in the hip capsule of children with developmental dysplasia (dislocation) of the hip (DDH) and non-DDH children in order to investigate the roles of TGF-ß₂ in hip joint laxity.

Methods: Eight children with DDH and eight age- and gender-matched non-DDH children (control group) were enrolled. The immunohistochemical technique (S-P method) was used to examine the distribution and content of TGF-ß₂ in the hip capsule.

[Expression of COL1a1 and COL3a1 in the capsule of children with developmental dislocation of the hip].

Objective: The etiology of developmental dislocation of the hip (DDH) remains uncertain, but some research has shown that this disorder is closely related to hip joint laxity. This study examined the expression of collagens type I and III mRNA and protein in the hip capsule of children with DDH in order to investigate the roles of collagens type I and III in hip joint laxity.

Methods: Nine children with DDH and nine age and gender-matched normal children (control group) were enrolled.

[Appropriate soil nitrate N content for a winter wheat/summer maize rotation system in North China Plain].

A field experiment with 12-level N fertilization in winter wheat growth season and zero-N in summer maize growth season was conducted to study the appropriate soil nitrate N content for a winter wheat/summer maize rotation system in North China Plain. The results showed that when the soil mineral N content before sowing was higher, a split application of 150 kg N x hm(-2) in winter wheat growth season could meet the N demand of both winter wheat and summer maize in the rotation system. The N use efficiency of winter wheat in different N treatments was only from 11% to 23%, while the residual N use efficiency of summer maize ranged from 30% to 52%.

[Studies on the mechanism of Cr-induced DNA damage in glouse].

Objective: To investigate the mechanism of Cr-induced DNA damage in glouse.

Methods: The studies were conducted at three pH values(pH 6.5, 7.