A New Azaphilone From the Marine Sponge-Associated Fungus Botryosporium pulchrum.

A new azaphilone, botryazaphilone (1), the first example of azaphilone featuring a 6/6/5/5 tetracyclic system, together with two known ones, chermesinone A (2) and perangustol B (3), had been obtained from the marine sponge-associated fungus Botryosporium pulchrum. The structure of 1 was elucidated through the analysis of spectroscopic data, whereas its absolute configuration was determined via single-crystal x-ray diffraction. It is the first report of the secondary metabolites isolated from the genus Botryosporium.

A new 3,4-dinorsteroid from the marine sponge sp.

A new steroid, 2a-oxa-2-oxo-5-hydroxy-3,4-dinor-24-methylcholesta-22-ene (), together with 10 known ones (), was isolated from the marine sponge sp. The structures of these compounds were determined by the spectroscopic methods (UV, IR, MS, and NMR) and X-ray diffraction analysis. Compound was the third example of 3,4-dinorsteroid with a hemiketal at C-5 that was isolated from the natural source.

Marcytoglobosins A and B, Cytochalasans From a Marine Sponge Associated Chaetomium globosum 162105 Fungus.

Two new cytochalasans, marcytoglobosins A (1) and B (2) were isolated from the marine sponge associated fungus Chaetomium globosum 162105, along with six known compounds (3-8). The complete structures of two new compounds were determined based on 1D/2D NMR and HR-MS spectroscopic analyses coupled with ECD calculations. All eight isolates were evaluated for their antibacterial activity.

(+)- and (-)-Tedanine, a pair of new enantiomeric indolone alkaloids from the marine sponge sp.

(+)- and (-)-Tedanine [(+)- and (-)-], a pair of new enantiomeric indolone alkaloids, along with nine compounds (-) were isolated from the marine sponge sp. The structures of (+)- and (-)- including absolute configurations were determined by spectroscopic analysis and quantum chemical calculation. Compounds (+)- and (-)- were the first examples of indolone alkaloids isolated from this genus.

Two New Pairs of Enantiomeric Butenolides from the Marine Sponge Suberties sp.

Two new pairs of enantiomeric butenolides, (+)- and (-)-suberiteslide A, (+)- and (-)-subertieslide B had been obtained from the marine sponge Suberties sp. The structures with absolute configurations of these compounds were unequivocally determined by spectroscopic analyses and ECD (Electronic Circular Dichroism) method. It was the first separation of butenolides from the marine sponges of genus Suberites.

Mixed-Linker Isoreticular Zn(II) Metal-Organic Frameworks as Brønsted Acid-Base Bifunctional Catalysts for Knoevenagel Condensation Reactions.

Multicomponent metal-organic frameworks (MOFs) have received an increasing amount of attention due to their potential to produce new topologies, pore metrics, and functionalities compared to MOFs with a single metal cluster and one organic linker. Herein, five isoreticular Zn MOFs were obtained by mixing two types of linear ditopic linkers in a one-pot solvothermal synthesis. Interestingly, in the resulting Zn MOFs a six-connected cyclic trinuclear Zn(II) cluster and an eight-connected linear trinuclear Zn(II) cluster coexist, leading to an uncommon (6,8)-connected network.

Two new halogenated metabolites from the red alga sp.

Two new halogenated metabolites, laurenhalogens A () and B (), along with four known ones (), were isolated from the red alga sp. The structures of and were determined by the means of UV, IR, MS, NMR and X-ray diffraction analysis. In addition, the antibacterial activities of - were also evaluated.

Nurses' perceptions regarding barriers to implementing the Internet Plus Nursing Service programme: A qualitative study.

Aim: The aim of this work is to investigate nurses' perceptions of barriers constraining the implementation of the Internet Plus Nursing Service program.

Background: The Internet Plus Nursing Service programme helps meet the demands of an ageing population, people with chronic diseases, the disabled, and home convalescents, and affirms the value of nurses. However, this programme has failed to elicit nurses' active participation, and there is limited knowledge regarding nurses' perceptions of the barriers to the programme's implementation.

A new amide from the marine sponge .

A new amide, baeriamide (1), along with nine known diketopiperazines (2-10), was isolated from the marine sponge Haliclona baeri. Their structures were identified by the means of UV, IR, MS and NMR. The absolute configuration of 1 was established by Marfey's method and comparing the specific optical rotation with the known compound HCO-Val-Gly methyl ester.

Applying molecular networking for targeted isolation of depsipeptides.

LC-HRMS/MS molecular networking enabled the targeted isolation of three new neoantimycin analogs (1, 3, 5) and two known ones (2, 4) from the culture broth of RJ8. After derivatization into C1-hydroxyl form compounds (6-10) respectively, the absolute structures of 1-5 were clearly determined by analyzing the hydrolyzed components from 6-10. Compounds 2 and 3 were confirmed to be a pair of epimers with different stereochemistry at C-2, and so were 4 and 5.

Asperfloketals A and B, the First Two Ergostanes with Rearranged A and D Rings: From the Sponge-Associated 16D-1.

Asperfloketals A () and B (), two 1(10 → 6)--14,15-secosteroids featuring a novel trioxahexaheterocyclic ring system, were isolated from the sponge-associated fungus 16D-1. Their structures were elucidated by extensive spectroscopic analysis and NMR chemical shifts calculations, supported by DP4+ probability analysis, and their absolute configurations were determined by ECD calculations and the modified Mosher's method. Asperfloketals A and B showed strong anti-inflammatory activity in the CuSO-induced transgenic fluorescent zebrafish but displayed no cytotoxicity against HeLa, HepG2, and SW480 cell lines.

Two new pyrrolidine alkaloids from the red alga .

Two new pyrrolidine alkaloids, acanthophoraines B () and C (), together with five known ones (-) were isolated from the red alga . Their structures were elucidated by extensive spectroscopic methods and single-crystal X-ray diffraction analysis. The absolute configuration of was established by ECD calculation.

Three New Butenolides from the Green Alga Caulerpa racemosa var. turbinata.

Three new butenolides, caulerpalide A and a pair of enantiomers, (+)-caulerpalide B and (-)-caulerpalide B, together with seven known compounds, have been isolated from the green alga Caulerpa racemosa var. turbinata. All these structures were determined by spectroscopic techniques.

Solieritide A, a new polyketide from the red alga sp.

A new polyketide, solieritide A (), along with six known ones (), had been isolated from the red alga sp. The structures of these compounds were elucidated by spectroscopic analysis. The absolute configuration of was determined by the method of X-ray diffraction.

(+)- and (-)-Spongiterpene, a pair of new valerenane sesquiterpene enantiomers from the marine sponge Sp.

(+)- and (-)-Spongiterpene [(+)- and (-)-], a pair of new valerenane sesquiterpene enantiomers, along with four known compounds (-) were isolated from the marine sponge sp. The structures of (+)- and (-)- including absolute configurations were determined by spectroscopic analysis, quantum chemical calculation and X-ray diffraction. Compounds (+)- and (-)- were the first examples of valerenane sesquiterpenes isolated from the marine sponges.

Acanthophoraine A, a new pyrrolidine alkaloid from the red alga .

A new pyrrolidine alkaloid, acanthophoraine A (), along with six known alkaloids (-), had been isolated from the red alga . The structures of these compounds were identified by spectroscopic analyses. The absolute configuration of was established by ECD calculation.

A new thiodiketopiperzaine from the marine sponge sp.

A new thiodiketopiperzaine, tedanizaine A (), together with six known ones, were isolated from the marine sponge sp. Their structures were determined by spectroscopic analyses. The absolute configuration of was established by ECD calculation.

Unusual anti-inflammatory meroterpenoids from the marine sponge Dactylospongia sp.

Five new sesquiterpene hydroquinones, dactylospongins A-D (1-4) and 19-O-methylpelorol (10), as well as four new sesquiterpene quinones, melemeleones C-E (6-8) and dysidaminone N (9), were isolated from the marine sponge Dactylospongia sp. collected from the South China Sea, along with five known analogues, ent-melemeleone B (5), pelorol (11), 17-O-acetylavarol (12), 20-O-acetylavarol (13), and 20-O-acetylneoavarol (14). The structures were elucidated by spectroscopic data analyses and comparison with the published NMR data, while the absolute configurations of new structures were assigned by comparison between the experimental and calculated ECD spectra.

Two new steroids with cytotoxicity from the marine sponge Dactylospongia elegans collected from the South China Sea.

A new steroid, (3S,5R,9R,10S,13R,17R,20R,24S,22E)-ergosta-6,8,22-triene-3,25-diol (1), and its sulfonated analogue (2) together with a known one, 5α,8α-epidioxy-cholest-6-en-3β-ol (3) were isolated from the marine sponge Dactylospongia elegans collected from the South China Sea. The new structures including absolute configurations were established by the HRESIMS and 1D and 2D NMR analysis coupled with the X-ray crystal analysis. Both of 1 and 2 exhibited cytotoxicity against cancer cell line MCF-7 with IC values of 9.

Antineoplastic activity of linear leucine homodipeptides and their potential mechanisms of action.

Galaxamide is a rare cyclic homopentapeptide composed of three leucines and two N-methyl leucines isolated from marine algae Galaxaura filamentosa. The strong antitumor activity of this compound makes it a promising candidate for tumor therapy. The synthesis of galaxamide, however, is a complex process, and it has poor water solubility.

Popolohuanones G - I, Dimeric Sesquiterpene Quinones with IL-6 Inhibitory Activity from the Marine Sponge Dactylospongia elegans.

Chemical investigation of the marine sponge Dactylospongia elegans, collected from the South China Sea, afforded three new dimeric sesquiterpene quinones, popolohuanones G - I (1 - 3), together with two known analogs, popolohuanones B (4) and C (5). The new structures were determined by HR-ESI-MS and 1D- and 2D-NMR analyses. All the five compounds showed no cytotoxic activity against five human cancer cell lines, while popolohuanone H (2) showed potent inhibitory activity against IL-6, an inflammatory cytokine, at the concentration of 10 μm.