Ablation of LKB1 gene changes the lipid profiles of goat intramuscular fat and enhances polyunsaturated fatty acids deposition.

The content and composition of intramuscular fat (IMF) affect the cooked meat palatability such as tenderness and juiciness. Thus, elucidation of lipid deposition and its composition in goat IMF is necessary. Here, Jianzhou big-ear goats with higher IMF content is associated with lower mRNA level of LKB1 gene, compared with those of Chuannan black goats.

Design of a novel high-speed tensile method for testing the high strain rate tensile behavior of aluminum alloys.

The high-strain rate mechanical behavior of aluminum alloys is crucial for the stability of electromagnetic launch systems. However, current high-strain rate testing methods are not suitable for large-scale screening of materials needed in electromagnetic launch systems due to their low precision and high cost. In this paper, a novel method for high-strain rate tensile testing of aluminum alloys based on magnetic pulse driving was proposed.

Porous MOFs with geometric mismatch between trimers and octatopic pyrene-based ligands for low-temperature methane storage.

Natural gas is recognized as a transitional clean energy fuel to address a variety of environmental problems. Identifying porous adsorbents with high-capacity low-temperature methane adsorption performances is crucial for advancing next-generation technologies for efficiently utilizing boil-off gas, inevitablely generated from liquefied natural gas systems. Herein, we synthesized highly porous metal-organic frameworks (MOFs)-TBPP-MOFs with a geometric mismatch strategy by combining seemingly incompatible trinuclear clusters with octatopic pyrene-based ligands.

CT-based delta-radiomics for predicting pathological response to neoadjuvant immunochemotherapy in esophageal squamous cell carcinoma: a multicenter study.

Background: The study aimed to investigate the predictive value of delta-radiomics derived from computed tomography (CT) for pathological complete response (pCR) to neoadjuvant immunochemotherapy (NICT) among patients with esophageal squamous cell carcinoma (ESCC), helping clinicians determine whether to modify the neoadjuvant treatment strategy, proceed to surgery, or forgo surgery altogether.

Methods: A total of 140 ESCC patients from two institutions (Database 1 = 93; Database 2 = 47) who underwent NICT and surgery were retrospectively included in the study. The training set consisted of patients from Database 1, while the testing set included patients from Database 2.

Screen Time and Autism Spectrum Disorder: A Comprehensive Systematic Review of Risk, Usage, and Addiction.

The relationship between autism spectrum disorder (ASD) and screen time (ST) has been extensively studied; but the evidence remains inconsistent, and a comprehensive quantitative synthesis of this association is lacking. This study aims to provide a robust quantitative assessment of the relationship between ASD and ST by consolidating and analyzing available evidence to offer a more precise understanding of this complex association. This systematic review followed PRISMA 2020 statement, and applied a quality assessment tool for quantitative studies to identity best available evidence.

miRNAs in HCC, pathogenesis, and targets.

Liver cancer is the third leading cause of cancer-related mortality worldwide. HCC, the most common type of primary liver cancer, is driven by complex genetic, epigenetic, and environmental factors. MicroRNAs, a class of naturally occurring small noncoding RNAs, play crucial roles in HCC by simultaneously modulating the expression of multiple genes in a fine-tuning manner.

Bottom-Up Strategy to Enhance Long-Range Order of Poly(Heptazine Imide) Nanorods for Efficient Photocatalytic CO Methanation.

Poly(heptazine imide) (PHI), one of the crystalline or long-range ordered allotropes of polymeric carbon nitride, is a promising polymeric photocatalyst; however, preparation of highly crystalline PHI remains a challenge. Herein, through a bottom-up strategy involving repair of structural defects and increase of specific surface area of melon precursor, we prepared PHI nanorods with dramatically improved long-range order. The resulting PHI exhibited a shift of product selectivity in CO photoreduction from CO to CH with a high methanation activity in contrast to the pristine PHI with relatively low long-range order.

Baicalein Long-Circulating Liposomes Improve Histological and Functional Outcomes After Traumatic Brain Injury.

High mortality and disability have been principally linked with traumatic brain injury (TBI) with this condition being a principal issue in public health. Currently, there is no reliable pharmaceutical agent to salvage the damage caused by TBI. Baicalein (BCL), a traditional Chinese medicine active ingredient, has preliminarily shown repair activity on brain injury.

Oxidative stress model of lipopolysaccharide combined with thrombin inducing in broiler chicks.

Lipopolysaccharides (LPS) are commonly used to construct inflammation models. However, poultry have a certain degree of tolerance to LPS due to the lack of thrombin XI and XII in their bodies. Thrombin activation produces clotting factors that can cleave prothrombin to form thrombin.

Evidence summary on perioperative non-pharmacological prophylaxis of venous thromboembolism in patients with pancreatic cancer.

Objective: To summarize the best evidence related to perioperative non-pharmacologic prophylaxis of venous thromboembolism in patients with pancreatic cancer, and improve the quality of clinical practice.

Methods: According to the "6S" evidence pyramid model, we searched guideline networks, professional society websites, and comprehensive databases for clinical decisions, clinical guidelines, expert consensus, evidence summaries, and systematic reviews related to perioperative non-pharmacological prophylaxis of venous thromboembolism in patients with pancreatic cancer. The literature quality assessment followed appropriate tools.

Engineering enzyme conformation within liquid-solid hybrid microreactors for enhanced continuous-flow biocatalysis.

The artificial engineering of an enzyme's structural conformation and dynamic properties to promote its catalytic activity and stability outside cellular environments is highly pursued in industrial biotechnology. Here, we describe an elegant strategy of combining the rationally designed liquid-solid hybrid microreactor with a tailor-made polyethylene glycol functional ionic liquid (PEG-IL) microenvironment to exercise a high level of control over the configuration of enzymes for practical continuous-flow biocatalysis. As exemplified by a lipase driven kinetic resolution reaction, the obtained system exhibits a 2.

Tauroursodeoxycholic acid mitigates depression-like behavior and hippocampal neuronal damage in a corticosterone model of female mice.

Depression, a complex mental disorder influenced by both psychological and physiological factors, predominantly affects females. Studies have indicated that elevated levels of cortisol/corticosterone (CORT) under stress conditions can lead to hippocampal neuronal damage, thereby contributing to depression. Tauroursodeoxycholic acid (TUDCA), a bile acid, possesses anti-apoptotic, antioxidant, and anti-inflammatory properties.