Publications by authors named "Shi C"

Lithium-sulfur batteries (LSB) with high theoretical energy density are plagued by the infamous shuttle effect of lithium polysulfide (LPS) and the sluggish sulfur reduction/evolution reaction. Extensive research is conducted on how to suppress shuttle effects, including physical structure confinement engineering, chemical adsorption strategy, and the design of sulfur redox catalysts. Recently, the rational design to mitigate shuttle effects and enhance reaction kinetics based on physical field effects has been widely studied, providing a more fundamental understanding of interactions with sulfur species.

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The study was to evaluate the clinical outcomes of azvudine versus nirmatrelvir-ritonavir against omicron strains of coronavirus disease 2019 infections and determine their comparative effectiveness. This retrospective study included 716 patients who received nirmatrelvir-ritonavir (NR group) or azvudine (FNC group) at Peking Union Medical College Hospital between 1 November 2022 and 27 February 2023. Patients in the FNC group (n = 304) were younger, exhibited less severe symptoms, started antiviral therapy later, received corticosteroids more frequently, and used tocilizumab less frequently than patients in the NR group (n = 412).

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  • The study explores the effectiveness of combining dexmedetomidine and dexamethasone with local anesthetic ropivacaine in extending pain relief after video-assisted thoracoscopic surgery (VATS).
  • Conducted in two hospitals, it involved 88 patients divided into groups receiving different combinations of the medications to evaluate their impact on pain duration and other outcomes.
  • Results showed that the combination of all three drugs significantly increased pain relief duration and reduced opioid consumption, with the RSM group experiencing less nausea post-surgery compared to others, although pain scores were similar across groups.
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Transfer printing, a crucial technique for heterogeneous integration, has gained attention for enabling unconventional layouts and high-performance electronic systems. Elastomer stamps are typically used for transfer printing, where localized heating for elastomer stamp can effectively control the transfer process. A key challenge is the potential damage to ultrathin membranes from the contact force of elastic stamps, especially with fragile inorganic nanomembranes.

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Anthocyanins are susceptible to degradation owing to environmental factors. Combining them with proteins can improve their stability; however, the interaction mechanism is difficult to elucidate. This study used multispectral and molecular dynamics simulations and molecular docking methods to investigate the interaction mechanism between peanut protein isolate (PPI) and cyanidin-3-O-glucoside (C3G).

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  • Influenza poses a severe global health risk, with research uncovering unique microbial communities in the respiratory tract that could influence infection resistance.
  • In mouse studies, transferring respiratory microbes from survivors of H9N2 influenza to antibiotic-treated mice improved their resistance to infection, particularly with higher levels of Aeromicrobium.
  • Metabolomic analysis identified increased LysoPE (16:0) in mildly infected mice, which appears to enhance anti-influenza defenses by suppressing certain inflammatory markers, suggesting Aeromicrobium camelliae as a potential preventative agent for influenza.
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  • The presence of both TERTp and BRAF mutations significantly increased the likelihood of having multiple distant metastases and led to a quicker progression to RAIR-DTC compared to patients with BRAF mutations alone.
  • The research suggests that testing for TERTp and BRAF mutations could help in early diagnosis and treatment planning for patients at risk of progressing to RAIR-DTC.
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Previous research has suggested that circulating inflammatory proteins are associated with benign prostatic disease (BPD). This Mendelian randomization (MR) study was conducted to further investigate the causal relationship between 91 inflammatory proteins and BPD. Genome-wide association study (GWAS) summarized data of benign prostatic hyperplasia (BPH) and prostatitis were obtained from the FinnGen Biobank.

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Introduction: Phenomenological qualitative research delves into the essence and meaning of phenomena through subjects' lived experiences. Despite its widespread use in humanities disciplines, its integration with psychopathology is rare in China.

Methods: We systematically reviewed phenomenological studies on schizophrenia in China to assess their content and quality and offer insights for future research.

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  • The study discusses the electrochemical reduction of carbon monoxide (CO) into valuable multi-carbon chemicals, focusing on challenges in achieving high selectivity with current catalysts.
  • Researchers developed a new catalyst called CuO/Ag@C, which is derived from metal-organic frameworks and shows a Faradaic efficiency of 48.6% for converting CO to methane (CH) while maintaining stability.
  • The catalyst's effectiveness is attributed to the unique combination of silver (Ag) and copper (Cu) that enhances CO production and optimizes electronic interactions, improving the overall reaction process for CH production.
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  • The liver is essential for detoxifying the body, and liver damage can occur if it becomes overwhelmed, highlighting the need for effective liver health maintenance.
  • Xiaobugan Decoction (XBGD), a traditional Chinese medicine, is used to support liver health, but its protective effects against liver injury were not well understood until this study.
  • The research found that XBGD helps protect liver cells and reduce liver injury by improving key enzyme levels, decreasing oxidative stress, and lowering inflammation in both cellular and mouse models.
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  • The study investigates how microbiota influences the immune response to influenza A virus (IAV) infection.
  • It finds that a specific commensal bacterium helps protect mice from IAV by enhancing the activity of virus-specific CD8 T cells.
  • Additionally, administering acetate mimicked this protective effect by altering metabolic processes in T cells, emphasizing the importance of microbiota-derived acetate in antiviral immunity.
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  • Scientists are studying how tiny structures in the kidneys form during development, especially how they branch out and work together.
  • They discovered that as these structures grow, they get packed tightly together, which can change how the cells make decisions.
  • The researchers used experiments and math to understand this packing and found that it affects how the kidneys develop over time in mice and might help in creating new tissues for medical purposes.
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  • * Nrf2 plays a vital role in reducing inflammation and oxidative stress, and its inhibition leads to worse inflammatory responses during renal IRI, as evidenced by increased NF-κB signaling activity.
  • * The study found that activating Nrf2 can reduce M1 macrophage polarization and mitigate the severity of renal IRI, suggesting that promoting Nrf2 activity could be a promising treatment strategy.
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  • Epithelioid glioblastoma (Ep-GBM) is a rare and aggressive brain tumor variant, with a high recurrence rate and poor prognosis; there’s currently no established standard treatment for it.
  • In a study of 58 Ep-GBM cases, common symptoms included headaches and dizziness, and the median survival rates were 12.7 months for progression-free survival and 29.1 months overall; reoperation after recurrence notably improved survival time.
  • Key factors influencing survival included tumor spread before initial surgery, the number of adjuvant temozolomide cycles received, and radiotherapy; extending the Stupp regimen with more temozolomide cycles could enhance outcomes for patients.
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  • Scientists created a smart computer program called deep learning to quickly guess the light properties of materials, which is super important for making new inventions.
  • This new program works better than eight other models and can accurately predict key light features like how materials absorb and emit light.
  • Using their predictions, researchers successfully made a new molecule that gives off deep blue light, proving their program is reliable and useful for developing new materials.
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  • MGF (mangiferin) shows potential in reducing acute liver injury (ALI) caused by carbon tetrachloride (CCl) through its antioxidant and anti-inflammatory properties.
  • Research demonstrated that MGF treatment lowers serum liver injury markers and inflammatory cytokines, while reducing cell death and promoting protective enzyme activity in liver tissue.
  • The protective effects of MGF are linked to the activation of the Nrf2-antioxidant response element (ARE) pathway, highlighting a possible mechanism for its therapeutic action against ALI.
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Ancient ivory serves as an important witness of time and historical events, offering highly significant insights into the fields of paleontology, mineralogy, materials science, and geochemistry. However, ancient ivory has undergone groundwater corrosion and has a loose porous structure and reduced mechanical strength due to being buried for a long time. Therefore, the temporary reinforcement and preservation of ancient ivory artifacts are a well-known challenge.

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  • The Stress-Coping Model (SCM) needs more research to see how it helps caregivers of elderly people with dementia in China deal with stress.
  • A study with 193 caregivers and their family members used different questionnaires to understand the impact of family burdens on caregivers' mental health.
  • The results showed that a heavy family burden increases stress for caregivers, but having good social support and positive ways of coping can help reduce this stress.
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Background: Comprehensive treatment of gastric cancer (GC) is progressing, but the rapid proliferation and metastasis of GC remains a cause of high recurrence and mortality rates. In this study we investigated GC-associated circRNA tending to yield more insight into the mechanisms of gastric cancer development.

Methods: We detected the expression levels of circTSN in GC tissues and cell lines using qRT-PCR.

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  • * Researchers developed CAR-M cells with a specific modification (CAR-shSIRPα-M) that showed improved tumor killing capabilities, particularly against HER2-positive tumors, while maintaining a good safety profile.
  • * The enhanced CAR-M cells not only inhibited tumor growth and improved survival in animal models but also boosted the infiltration of T-cells into tumors, suggesting a promising new avenue for improving cancer immunotherapy strategies.
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A N-heterocyclic carbene-catalyzed (NHC) three-component reaction involving -aminopyridinium salts, alkenes, and aldehydes for the synthesis of β-amino ketones is described. In this reaction, -aminopyridinium salts and the Breslow intermediate, which is generated from NHC and aldehydes, are utilized to undergo a single-electron transfer process, forming a ketyl radical intermediate and amidyl radicals. Subsequent to the formation of the amidyl radical, it undergoes selective capture by alkenes, followed by radical cross-coupling to yield the desired β-amino ketones.

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  • This study investigates the link between gut microbiome and asthma using advanced genetic methods to explore how gut bacteria influence asthma development.
  • Researchers analyzed genetic data from over 82,000 asthma cases and 640,000 controls, identifying specific gut bacteria associated with both reduced and increased asthma risk.
  • The results show significant genetic correlations and suggest that gut microbiota may serve as important targets for new asthma treatment approaches.
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  • Researchers are exploring sulfur-rich polymers made from elemental sulfur to improve industrial waste management and recycling processes.
  • The study investigates a new method of copolymerization involving sulfur and cyclic disulfides, resulting in strong and adaptable copolymers with high optical clarity.
  • This dynamic approach allows for easier recycling of the materials due to reversible chemical bonds, paving the way for advanced applications of sulfur-based polymers.
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