[Comparison of short-term clinical efficacy between CO external fixation and internal fixation with steel plate in the treatment of unstable distal radius fractures].

Objective: To evaluate the short-term clinical efficacy of external fixation and internal fixation with steel plate in the treatment of unstable distal radius fractures (AO-23C type), based on the principles of Chinese osteosynthesis (CO).

Methods: Forty-eight patients with unstable distal radius fractures between January 2022 and February 2023 were retrospectively analyzed and divided into the CO external fixation group and internal fixation group. CO external fixation group consisted of 25 patients, including 7 males and 18 females, aged from 37 to 56 years old with an average of ( 52.

Efficacy and application potential of purified hydrocolloid coatings sprayed onto maize seeds subjected to anti-aging.

The use of purified hydrocolloids extracted from waste-activated sludge has significant potential for preventing seed deterioration caused by aging. In this study, we compared the advantages and disadvantages of 3 types of purified hydrocolloid seed coatings from different waste sludges and one commercial seed coating at different spraying times (2, 4, 6, and 8). Compared with coated maize seeds, uncoated maize seeds underwent significant functional changes during the aging process according to the infrared spectroscopy results.

Automatic path planning for pelvic fracture reduction with multi-degree-of-freedom.

Background And Objectives: Computer-assisted orthopedic surgical techniques and robotics has improved the therapeutic outcome of pelvic fracture reduction surgery. The preoperative reduction path is one of the prerequisites for robotic movement and an essential reference for manual operation. As the largest irregular bone with complicated morphology, the rotational motion of pelvic fracture fragments impacts the reduction process directly.

Optical properties of quasi-two-dimensional GaAs/AlGaAs nanosheets prepared by releasing epitaxial layer.

Quasi-two-dimensional nanosheets exhibit novel properties and promising applications in optoelectronic flexible devices. Research on non-layered III-V semiconductor nanosheets has been constrained by their covalent bonding connections. In this study, GaAs/AlGaAs heterojunction nanosheets were prepared by releasing an epitaxial layer, and their optical properties were investigated by adopting steady-state and transient absorption spectroscopy.

NHC-Based Deep-Red Phosphorescent Iridium Complexes Featuring Three-Charge (0, -1, -2) Ligands.

N-heterocyclic carbene (NHC)-based phosphorescent iridium complexes have attracted extensive attention due to their good optical properties and high stability in recent years. However, currently reported NHC-based iridium complexes can easily achieve emission of blue, green, or even ultraviolet light, while emission of red or deep-red light is relatively rare. Here, we report a new family of NHC-based deep-red iridium complexes (Ir1, Ir2, Ir3, and Ir4) featuring three-charge (0, -1, -2) ligands.

The role of metagenomic next-generation sequencing in diagnosing and managing post-kidney transplantation infections.

Kidney transplantation (KT) is a life-saving treatment for patients with end-stage renal disease, but post-transplant infections remain one of the most significant challenges. These infections, caused by a variety of pathogens, can lead to prolonged hospitalization, graft dysfunction, and even mortality, particularly in immunocompromised patients. Traditional diagnostic methods often fail to identify the causative organisms in a timely manner, leading to delays in treatment and poorer patient outcomes.

Multifunctional Nanozyme with Aptamer-Based Ratiometric Fluorescent and Colorimetric Dual Detection of Prostate-Specific Antigen.

The adsorption of DNA probes onto nanomaterials represents a promising bioassay technique, generally employing fluorescence or catalytic activity to generate signals. A significant challenge is maintaining the catalytic activity of chromogenic catalysts during detection while enhancing accuracy by overcoming the limitations of single-signal transmission. This article presents an innovative multimodal analysis approach that synergistically combines the oxidase-like activity of Fe-N-C nanozyme (Fe-NC) with red fluorescent carbon quantum dots (R-CQDs), further advancing the dual-mode analysis method utilizing R-CQDs@Fe-NC.

Cross-Cultural Adaptation and Validation of the Central Sensitization Inventory Into Simplified Chinese.

Purpose: To translate the Central Sensitization Inventory from English into simplified Chinese (CSI-sC) and test the psychometric properties of the CSI-sC in patients with chronic pain.

Design: A cross-sectional design was used.

Methods: Cross-cultural adaptation of the CSI-sC was performed following Beaton's guidelines.

The role of 5-hydroxytryptamine on expulsion of Trichinella spiralis during the intestinal stage.

During the intestinal stage of Trichinella spiralis (T. spiralis) infection, it can stimulate host's intestinal peristalsis to expulse worms. 5-hydroxytryptamine (5-HT) is a neurotransmitter which can regulate the contraction of intestinal smooth muscle.

Synergistic effect of canine FGF-21 combined with insulin in the treatment of canine diabetes.

Previous studies have shown that FGF-21 can ameliorate hyperglycemia and improve the level of oxidative stress in vivo in diabetic mice. The hypoglycemic effect is safe and lasting, but it takes a longer time to exert its effect. Insulin treatment of canine diabetes takes effect quickly; however, its action time is short, and it is prone to cause hypoglycemia.

Deciphering Immunometabolic Landscape in Rheumatoid Arthritis: Integrative Multiomics, Explainable Machine Learning and Experimental Validation.

Purpose: Immunometabolism is pivotal in rheumatoid arthritis (RA) pathogenesis, yet the intricacies of its pathological regulatory mechanisms remain poorly understood. This study explores the complex immunometabolic landscape of RA to identify potential therapeutic targets.

Patients And Methods: We integrated genome-wide association study (GWAS) data involving 1,400 plasma metabolites, 731 immune cell traits, and RA outcomes from over 58,000 participants.

Combination of adenosine blockade and ferroptosis for photo-immunotherapy of triple negative breast cancer with aptamer-modified copper sulfide.

Combination of immunotherapy and photothermal therapy (PTT) provides a promising therapeutic performance for tumors. However, it still faces negative feedback from suppressive factors such as adenosine. Herein, we developed a new nanodrug that can combine adenosine blockade and ferroptosis to promote the photoimmunotherapy of triple negative breast cancer (TNBC).

Efficacy and safety of non-invasive low-frequency tibial nerve stimulator in overactive bladder.

Objectives: To evaluate the efficacy and safety of a non-invasive low-frequency tibial nerve stimulator (TNS-01) vs sham control in relieving the symptoms of overactive bladder (OAB) patients.

Patients: Participants who were diagnosed with primary OAB or exhibited at least one OAB symptom. All participants underwent three 30-min intervention sessions weekly.

Exploring Ubiquitination in Spinal Cord Injury Therapy: Multifaceted Targets and Promising Strategies.

Spinal cord injury (SCI) is a severely debilitating neurological condition that often results in significant functional impairment and is associated with poor long-term prognosis. Edema, oxidative stress, inflammatory responses, and cell death are the primary factors contributing to secondary injury following spinal cord damage. Ubiquitination is a crucial intracellular mechanism for protein regulation that has garnered significant attention as a therapeutic target in a variety of diseases.

Triterpenoid saponins from Rubus setchuenensis roots and their anti-inflammatory activities in vitro.

Previously undescribed triterpenoid saponins (1-8), along with eight previously reported analogues (9-16), were isolated from an EtOAc extract obtained from the roots of Rubus setchuenensis. Structures were established based on HRESIMS, 1D and 2D NMR, as well as by literature comparisons. All compounds were isolated for the first time from the genus Rubus.

Fabrication of alginate dialdehyde-gelatin crosslinked hydrogels incorporated with cinnamaldehyde nanoparticles for meat preservation.

Meat spoilage caused by Salmonella Typhimurium (S. typhimurium) contamination has become a major concern worldwide. Herein, the antibacterial mechanisms of cinnamaldehyde (CIN) against S.

IFIH1 promotes apoptosis through the TBK1/IRF3 pathway in triple-negative breast cancer.

Triple-negative breast cancer (TNBC) is a highly aggressive subtype of breast malignancy. Although some patients benefit from immune checkpoint therapy, current treatment methods rely mainly on chemotherapy. It is imperative to develop predictors of efficacy and identify individuals who will be sensitive to particular treatment regimens.

A TaqMan-MGB Probe Quantitative PCR Assay Detecting Hematodinium perezi.

Hematodinium perezi, a pathogenic dinoflagellate, is one of major epidemiological agents that lead to severe losses of cultured marine crustaceans in China. This study aimed to develop a novel, sensitive and specific detection method qualified for early surveillance and control of the disease caused by H. perezi.

Myeloid dendritic cells and periodontal disease association: integrated study of single-cell sequencing and Mendelian randomization analysis.

Background: Periodontal disease is a widespread inflammatory condition that compromises the supporting structures of the teeth, potentially resulting in tooth loss if left untreated. Despite advancements in therapeutic interventions and an enhanced understanding of its pathophysiology, emerging techniques such as single-cell RNA sequencing (scRNA-seq) and Mendelian randomization (MR) present new opportunities for precision medicine in the management of periodontal disease.

Methods: Data derived from the GSE152042 dataset underwent rigorous quality control, normalization, and dimensionality reduction using Seurat and the MonacoImmuneData framework.

Vascular flow alteration is a dominant pattern of liver pathology in patients with orthotopic lung transplants: a retrospective observational study.

Aims: The number of orthotopic lung transplants (OLT) has skyrocketed since the 1960s, generating an ever-increasing cohort of post-OLT patients. Many challenges exist in the post-OLT timeframe, including donor graft dysfunction, infection, malignancy, and immunosuppression-related conditions. A rather elusive topic in the posttransplant setting remains the impact of the underlying disease process and donor lungs on other organ systems and the complications arising from the complex physiologic interactions.

Outcome evaluation and cost-effectiveness analysis for an integrated multidisciplinary diabetic limb salvage program: a combined observational and simulation study.

Introduction: To compare the clinical outcomes and healthcare utilization of patients enrolled in the multidisciplinary Diabetic Foot in Primary and Tertiary (DEFINITE) Care program with a matched historical cohort and estimate the program's long-term cost-effectiveness using simulation.

Research Design And Methods: This study consisted of two components: a 1-year observational outcome evaluation and a long-term simulation-based cost-effectiveness analysis (CEA). We conducted an observational study to analyze 2798 patients with diabetic foot ulcers (DFUs) enrolled in the program between June 2020 and June 2021 (DEFINITE Care group) and 5462 patients with DFUs from June 2016 to December 2017 as historical controls.

Inhibition of KLF5 promotes ferroptosis via the ZEB1/HMOX1 axis to enhance sensitivity to oxaliplatin in cancer cells.

As a novel form of nonapoptotic cell death, ferroptosis is developing into a promising therapeutic target of dedifferentiating and therapy-refractory cancers. However, its application in pancreatic cancer is still unknown. In the preliminary research, we found that F-box and WD repeat domain-containing 7 (FBW7) inhibited the migration and proliferation of pancreatic cancer cells through its substrate c-Myc.

Changes in arthropod family richness, activity-density, biomass and body-size differed along a grazing intensity gradient: Modulation of plant traits and soil moisture conditions.

Arthropods play a critical role in the functioning of grassland ecosystems, and are largely affected by herbivore grazing. However, the mechanisms of grazing affecting arthropod community, especially through modulating plant traits and soil properties, are still unclear. We investigated the variation in arthropod community variables including family richness, activity-density, biomass, and body size in typical steppe grasslands subject to grazing at four intensity levels (nil, light, moderate and heavy) in central Inner Mongolia (China), and analyzed the relationships of these variations with grazing-induced changes in plant traits, plant community attributes and soil properties.

Recent Advances in Nontargeted Screening of Chemical Hazards in Foodstuffs.

The emergence of several chemical substances continues to enrich and facilitate the development of food science, but their irrational use also poses a threat to food safety and human health. Nontargeted screening (NTS) has become an important tool for rapid traceability and efficient identification of chemical hazards in food matrices. NTS in food analysis is highly integrated with sample pretreatment, instrumental analysis platforms, data acquisition and analysis, and toxicology.