Publications by authors named "Shi Biao Chia"
Peroxiredoxins and Beyond; Redox Systems Regulating Lung Physiology and Disease.
Antioxid Redox Signal
November 2019
Article Synopsis
- * PRDXs work alongside other redox systems like thioredoxin and sulfiredoxin, and their function extends beyond scavenging to include chaperone activities that influence various cellular processes.
- * Despite their importance, there is still limited knowledge about how PRDXs contribute to lung diseases, highlighting a need for more research into their roles in inflammation, injury, and repair processes.
Nuclear Factor kappa B (NF-κB) is a transcription factor family critical in the activation of pro- inflammatory responses. The NF-κB pathway is regulated by oxidant-induced post-translational modifications. Protein S-glutathionylation, or the conjugation of the antioxidant molecule, glutathione to reactive cysteines inhibits the activity of inhibitory kappa B kinase beta (IKKβ), among other NF-κB proteins.
View Article and Find Full Text PDFAblation of Glutaredoxin-1 Modulates House Dust Mite-Induced Allergic Airways Disease in Mice.
Am J Respir Cell Mol Biol
September 2016
Protein S-glutathionylation (PSSG) is an oxidant-induced post-translational modification of protein cysteines that impacts structure and function. The oxidoreductase glutaredoxin-1 (Glrx1) under physiological conditions catalyzes deglutathionylation and restores the protein thiol group. The involvement of Glrx1/PSSG in allergic inflammation induced by asthma-relevant allergens remains unknown.
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