Open-loop narrowband magnetic particle imaging based on mixed-frequency harmonic magnetization response.

Introduction: Magnetic particle imaging (MPI), a radiation-free, dynamic, and targeted imaging technique, has gained significant traction in both research and clinical settings worldwide. Signal-to-noise ratio (SNR) is a crucial factor influencing MPI image quality and detection sensitivity, and it is affected by ambient noise, system thermal noise, and the magnetization response of superparamagnetic nanoparticles. Therefore to address the high amplitude system and inherent thermal noise present in conventional MPI systems is essential to improve detection sensitivity and imaging resolution.

Research on Spatial Localization Method of Magnetic Nanoparticle Samples Based on Second Harmonic Waves.

Existing magnetic tracer detection systems primarily rely on fundamental wave signal acquisition using non-differential sensor configurations. These sensors are highly susceptible to external interference and lack tomographic localization capabilities, hindering their clinical application. To address these limitations, this paper presents a novel method for achieving the deep spatial localization of tracers.

Distribution of calbindin-positive neurons across areas and layers of the marmoset cerebral cortex.

The diversity of the mammalian cerebral cortex demands technical approaches to map the spatial distribution of neurons with different biochemical identities. This issue is magnified in the case of the primate cortex, characterized by a large number of areas with distinctive cytoarchitectures. To date, no full map of the distribution of cells expressing a specific protein has been reported for the cortex of any primate.

Improved Femtosecond Laser Welding of Nonoptical Contact Glass by Pressure and a Water Intermediate Layer.

Ultrafast laser welding has emerged as a significant technology for the joining of transparent materials and has been extensively researched for the welding of glass materials in recent years. However, achieving a robust connection requires optical contact between the samples during laser processing, which complicates the welding process and increases its cost. To achieve high-strength welding of glass samples without optical contact, the samples are typically pressed together to minimize the gap, allowing the molten materials to completely fill it.

Inhibition of 5-HT alleviates PTSD-like behaviors and promotes hippocampal neuroplasticity by modulating hippocampal autophagy in rats.

5-Hydroxytryptamine (5-HT) plays a substantial role in mitigating depression and anxiety. However, the potential effects of 5-HT against posttraumatic stress disorder (PTSD) and its underlying mechanisms remain unclear. Elevated plus maze test evaluates anxiety-related behaviors, and the open field test is used to assess overall activity levels and anxiety.

MYC and p53 alterations cooperate through VEGF signaling to repress cytotoxic T cell and immunotherapy responses in prostate cancer.

Unlabelled: Patients with castration-resistant prostate cancer (CRPC) are generally unresponsive to tumor targeted and immunotherapies. Whether genetic alterations acquired during the evolution of CRPC impact immune and immunotherapy responses is largely unknown. Using our innovative electroporation-based mouse models, we generated distinct genetic subtypes of CRPC found in patients and uncovered unique immune microenvironments.

A high security coding and anti-counterfeiting method based on the nonlinear magnetization response of superparamagnetic nanomaterials.

Traditional coding methods based on graphics and digital or magnetic labels have gradually decreased their anti-counterfeiting because of market popularity. This paper presents a new magnetic anti-counterfeiting coding method. This method uses a high-performance coding material, which, along with small changes to the material itself and the particle size of the superparamagnetic nanomaterials, results in a large difference in the nonlinear magnetization response.

Measurement method of virtual image distance for a head-mounted display based on a variable-focus liquid lens.

The distance from the virtual image to the human eye is an important factor in measuring the comfort of a head-mounted display (HMD). However, accurately measuring their distance is challenging due to the dynamic changes in virtual presence and distance. In this paper, we proposed a virtual image distance measurement prototype based on a variable-focus liquid lens and derived a virtual image distance calculation model.

Synthesis of Isoxazol-5(2)-one Derivatives via (BuO)Mg Promoted [3 + 2] Annulations of δ-Acetoxy Allenoates with Hydroxylamine.

Herein, an efficient (BuO)Mg promoted [3 + 2] annulation of δ-acetoxy allenoates with -benzylhydroxylamine has been developed. This method provides a concise and facile protocol to synthesize vinylated isoxazol-5(2)-one derivatives stereospecifically in a broad substrate scope with high efficiency (31 examples, up to 87% yield).

Magnetic leakage behavior assessment in pipeline stress-concentrated areas using improved force-magnetic coupling model.

Magnetic flux leakage (MFL) technology is remarkable for its capability to detect pipeline geometric deformation and general corrosion defects. However, it cannot characterize the MFL behavior in stress-concentrated areas, thereby greatly challenging the subsequent pipeline maintenance. This study suggests that the MFL characteristics of pipeline in stress-concentrated areas are caused by the combined effect of the face magnetic charge on the deformed end-face and the body magnetic charge of the dislocation stack.

Development of high-efficiency superparamagnetic drug delivery system with MPI imaging capability.

In this study, a high-efficiency superparamagnetic drug delivery system was developed for preclinical treatment of bladder cancer in small animals. Two types of nanoparticles with magnetic particle imaging (MPI) capability, i.e.

Metaplastic regeneration in the mouse stomach requires a reactive oxygen species pathway.

In pyloric metaplasia, mature gastric chief cells reprogram via an evolutionarily conserved process termed paligenosis to re-enter the cell cycle and become spasmolytic polypeptide-expressing metaplasia (SPEM) cells. Here, we use single-cell RNA sequencing (scRNA-seq) following injury to the murine stomach to analyze mechanisms governing paligenosis at high resolution. Injury causes induced reactive oxygen species (ROS) with coordinated changes in mitochondrial activity and cellular metabolism, requiring the transcriptional mitochondrial regulator Ppargc1a (Pgc1α) and ROS regulator Nf2el2 (Nrf2).

Development of a human-size magnetic particle imaging device for sentinel lymph node biopsy of breast cancer.

In this study, a novel human-size handheld magnetic particle imaging (MPI) system was developed for the high-precision detection of sentinel lymph nodes for breast cancer. The system consisted of a highly sensitive home-made MPI detection probe, a set of concentric coils pair for spatialization, a solenoid coil for uniform excitation at 8 kHz@1.5 mT, and a full mirrored coil set positioned far away from the scanning area.

Research progress of exosomes in drug resistance of breast cancer.

Since breast cancer is a heterogeneous disease, there are currently a variety of treatment methods available, including chemotherapy, endocrine therapy, molecular targeted therapy, immunotherapy, radiation therapy, etc. Breast cancer recurrence and metastasis, despite many treatment modalities, constitute a considerable threat to patients' survival time and pose a clinical challenge that is difficult to tackle precisely. Exosomes have a very special and crucial role in the treatment of drug resistance in breast cancer as a carrier of intercellular communication in the tumor microenvironment.

Uveal Melanoma Metastasis to the Thyroid.

Background: Around 1.2 to 3.1% of thyroid malignancies are due to metastasis.

NHC-catalyzed formal [3 + 3] annulations of δ-acetoxy allenoates for the synthesis of 4-pyran derivatives.

Herein, an N-heterocyclic carbene (NHC) catalyzed formal [3 + 3] annulation of δ-acetoxy allenoates with 1C,3O-bisnucleophiles for the construction of 4-(fused)pyrans has been developed. This protocol provides a facile method to synthesize highly functionalized 4-pyrans and has a broad substrate scope (30 examples, up to 77% yield).

Single-cell sequencing of ascites fluid illustrates heterogeneity and therapy-induced evolution during gastric cancer peritoneal metastasis.

Peritoneal metastasis is the leading cause of death for gastrointestinal cancers. The native and therapy-induced ascites ecosystems are not fully understood. Here, we characterize single-cell transcriptomes of 191,987 ascites cancer/immune cells from 35 patients with/without gastric cancer peritoneal metastasis (GCPM).

/20 surface nanostructuring of ZnO by mask-less ultrafast laser processing.

Fabrication of nanostructures with a feature size much smaller than the laser wavelength is challenging due to the optical diffraction limit. It's well known that the irradiation of polarized ultrafast laser generates periodic nanostructures, so called laser-induced periodic surface structures (LIPSS). Owing to the modulated field, the surface is periodically ablated to form specific patterns, which can be used for some photonic applications including surface-enhanced Raman scattering (SERS).

A Temperature Imaging Method for Multi-Chip High Power LEDs Based on the Magnetic Nanoparticle Thermometer.

In this study, a temperature imaging method based on a magnetic nanoparticle thermometer is proposed and evaluated. We first constructed a new model for finding the single temperature of magnetic nanoparticles with core size distribution. Specifically, we employed an air-core coil as a magnetic probe, which measured the magnetization of magnetic nanoparticles (MNPs).

Extra-axial Chordoma of the Sternoclavicular Joint.

Chordomas are rare, slowly growing, aggressive primary bone tumors that originate from notochord remnants and occur almost exclusively in the axial skeleton. Here, we describe a patient with an enlarging right-sided neck mass that was later diagnosed as a sternoclavicular joint chondroid chordoma. En bloc surgical resection was accomplished with negative margins.