Publications by authors named "Shezaib Siddiqui"
Article Synopsis
- Antibiotic resistance in Methicillin Resistant Staphylococcus aureus (MRSA) necessitates the search for new drug targets, particularly focusing on urease subunit gamma, a key virulence factor in MRSA that helps bacteria survive under acidic conditions.
- The study involved cloning, purifying, and testing 100 US-FDA approved drugs against urease subunit gamma using STD-NMR spectroscopy, with 15 drugs showing significant interactions.
- The research evaluated the drugs' effects on the thermal stability of urease and their ability to inhibit urease activity, suggesting their potential as therapeutic agents against MRSA, warranting further investigation.
During an investigation into the potential union of Lewis basic isothiourea organocatalysis and gold catalysis, the formation of gold-isothiourea complexes was observed. These novel gold complexes were formed in high yield and were found to be air- and moisture stable. A series of neutral and cationic chiral gold(I) and gold(III) complexes bearing enantiopure isothiourea ligands was therefore synthesized and fully characterized.
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