Antimalarial Activities of ()-2-(Nitroheteroarylmethylene)-3(2)-Benzofuranone Derivatives: and Assessment and β-Hematin Formation Inhibition Activity.

A series of ()-2-(nitroheteroarylmethylene)-3(2)-benzofuranones possessing nitroheteroaryl groups of nitroimidazole, nitrofuran, and nitrothiophene moieties was screened for antiplasmodium activity against a drug-sensitive strain (3D7 strain) and a multidrug-resistant (chloroquine [CQ] and pyrimethamine) strain (K1 strain) of Plasmodium falciparum. 5-Nitroimidazole and 4-nitroimidazole analogs were highly selective and active against resistant parasites, while 5-nitrofuran and 5-nitrothiophene derivatives were more potent against the 3D7 strain than against the K1 strain. Among the synthetic analogues, ()-6-chloro-2-(1-methyl-5-nitroimidazol-2-ylmethylene)-3(2)-benzofuranone (compound 5h) exhibited the highest activity (50% inhibitory concentration [IC], 0.

Free Radical Scavenging Principles of Boiss. Aerial Parts.

Boiss. is an aromatic perennial plant traditionally used for its anxiolytic and sedative properties. In the present study, various fractions and essential oil of aerial parts were investigated to find its free radical scavenging principles.

New ursane triterpenoids from Salvia urmiensis Bunge: Absolute configuration and anti-proliferative activity.

Two new triterpenoids, urmiensolide B (1) and urmiensic acid (2), with rare carbon skeletons together with three known compounds were isolated from the aerial parts of Salvia urmiensis Bunge, an endemic species of Iran. The structures were established by a combination of 1D and 2D NMR, and HRESIMS, and in the case of 2 and 3, their structures were confirmed by single-crystal X-ray analysis. The absolute configuration of 2 was established by electronic circular dichroism (ECD) spectra.