[The use of chloride-sulfate, magnesium, calcium, and sodium-rich mineral water for the prevention of stomatological diseases in workers of non-ferrous metal industry in arctic polar regions].

A new combined therapeutic modality is proposed to provide stomatological care for subjects engaged in non-ferrous metal industry in polar regions. Data on its advantages over the traditional approach in terms of efficacy are presented.

[Corrective action of the microwave electromagnetic field on progeny development in rats with impared uteroplacental circulation].

The experiment on 71 non-inbred white pregnant rats, 316 fetuses and placentas, 323 first progeny in experimental chronic impairment of uteroplacental circulation in females with pregnancy in the ploid period has found that decimetric waves (DW) in a weak heat dose (40 mW/cm2) prevents hypotrophy and disorders of fetal and placental development. Also, DW accelerate formation of motorsensory reflexes in the progeny in an early neonatal period and normalize their behavioral reactions at a mature age. The findings may serve experimental-theoretical grounds for application of weak heat DW radiation in obstetric practice in various general and regional hemocirculation.

[The corrective action of limontar in metabolic disorders in the mother-fetus system caused by ethanol exposure during pregnancy].

It was established in experiments on nonbred albino rats that injection of limontar (1 mg/kg) in the fetal period of pregnancy in alcoholic intoxication (6 g/kg) leads to weight loss by the female, normalization of the character of behavior and metabolic shifts in the organism, and removal of the symptoms of excitation of the sympathetic link of cardiovascular system regulation. No harmful effect of limontar on the mother-fetus biosystem was detected.

[New possibilities for metabolic protection from hypoxia in pregnant rats and their progeny].

Individual resistance of pregnant rats and the newborns to acute hypoxic hypoxia was studied. It was found that individual resistance of the organism to hypoxia significantly decreases in the last period of pregnancy. A new drug limontar proved to possess the properties of an active antihypoxia agent.

[The corrective properties of glycine in alcoholic intoxication in the fetal period of pregnancy].

Natural metabolite glycine administered per os to rats in the fetus period of pregnancy in a dose of 1 mg/kg was found to exert a corrective action with respect to the toxic effect of ethanol in the mother-fetus system. Glycine prevents loss in the body weight, normalizes functional state of the nervous system and metabolic disorders in the maternal organism, improve the redox processes in the lymphocytes changed under alcoholization, and protect the fetus both on the metabolic and microstructural levels.

[The protective action of limontar in pregnant animals with acute hypoxic hypoxia].

A comparative study of individual resistance of rats to acute hypoxic hypoxia was performed. It was shown that individual resistance of the organism to hypoxia significantly decreases in the course of pregnancy. Limontar is shown to be active antihypoxant.

[The transplacental transit and action of ceftazidime on the fetus in an experiment on animals at different times of the pregnancy].

The experiments were conducted on pregnant albino rats to study the transplacental transit of ceftazidime (Fortum) to the fetus on days 14 and 21 of pregnancy after a single intramuscular injection of 100 mg/kg. The antibiotic transition was 5.23, and 51.

[The effect of antenatal nicotine exposure on the male germ cells in Wistar rats].

Chemically pure nicotine in dose 0.4, 1.5 and 5.

[A clinico-experimental study of the tocolytic properties of salbupart in treating threatened abortion].

Clinical and experimental studies have revealed that salbupart, a beta-mimetic agent, administered in a dose of 0.14 mg/kg (the maximal therapeutic dose) markedly inhibited the spontaneous and oxytocin-induced uterine contractility, caused no embryotoxic or teratogenic effects, and did not influence fetal growth and development. The efficacy of salbupart tocolytic therapy was estimated as 75%.

[The use of the perfused rat heart as a model for selecting antihypoxic compounds].

The test system for selection of antihypoxic compounds was developed and approved on the basis of the model of the perfused rat heart. It was found that the hypoxic state of the moderate degree of severity simulated on the myocardium is optimal for the assessment of the studied antihypoxic compounds. Taking into consideration the fact that at the early stages of hypoxia the electron transport is disordered at the level of the first enzymatic complex of the respiration chain, the protective actions of the agents (menadione and hydroquinone) being able of shunting the respiration chain to bypass the damaged area were studied.

[Protective effect of narcotic analgesics on the mother, fetus and offspring in hypoxia].

The protective effect of the narcoanalgetics, viadril (hydroxydione sodium succinate) and administered intraperitoneally in doses of 5 and 20 mg/kg was studied in the experiment on 146 pregnant noninbred white rats with simulated hemic hypoxia in the late pregnancy (the 19th day). The aforementioned rats were studied for the composition of the peripheral blood, their weight gain oxidative isoenzymes (LDH), pH and pO2 in the blood. Wilson's technique was used for the assessment of the fetal status.

[Effect of fenibut and seduxen on fetal development in the second half of pregnancy].

In experiments on rats it was found that fenibut (50 mg/kg, 1/20 of LD50) during a single and repeated administration in the fetus period of pregnancy does not exert any negative effect on the maternal organism, the growth and development of the fetus. Seduxen administered in a dose of 50 mg/kg (1/80 of LD50) alone and in combination with fenibut was shown to decrease the female body weight gain and to disturb the fetus development. Following a single administration on the 17th day of pregnancy, the effect was poorly pronounced.

[Analysis of the damaging action of different doses of nicotine on the female germ cells of rat fetuses].

The conducted studies have shown the gametotropic dose-dependent nicotine effect revealed both at the light-optic and ultrastructural levels. The revealed disturbances in oocytes may be regarded as a nonspecific response of the sex cells which is observed mainly in damage of the membrane oocyte components and specific (for sex cells) structure, a synaptonemal complex. Disturbances in the somatic ovary cells manifest only with a high nicotine dose.

[Postnatal development of rat progeny after antenatal nicotine exposure].

The authors studied the effect of a chemically pure nicotine on the development of the first-generation progeny after subcutaneous injection of the drug into female rats throughout the entire pregnancy. The drug was injected daily with a four-hour interval, the total doses being 5; 1,5 and 0.4 mg/kg (1/5, 1/20 and 1/70 of the LD50).