Publications by authors named "Sheung Chan"

Signatures of immune dysregulation as clinical biomarker for psychosis have remained unclear. We aimed to compare the Neutrophil-to-lymphocyte ratio (NLR) of patients with acute non-affective first-episode psychosis (FEP) with healthy controls after accounting for emotional states. We also explored the associations of NLR with symptom severity, onset profile and cognitive functions.

View Article and Find Full Text PDF
Article Synopsis
  • Schizophrenia (SCZ) is a complex mental health disorder influenced by genetic factors, with studies revealing a gap in understanding due to undetected medium-sized structural variants (SVs).
  • The research aimed to identify these SVs in families with chronic SCZ characterized by severe negative symptoms and cognitive deficits.
  • By using advanced third-generation sequencing techniques, the study discovered 88 SVs associated with 79 genes, linking them to important brain functions and development pathways, which could help explain some aspects of the heritability of SCZ.
View Article and Find Full Text PDF

In the wake of the COVID-19 pandemic, contact tracing apps have been developed based on digital contact tracing frameworks. These allow developers to build privacy-conscious apps that detect whether an infected individual is in close proximity with others. Given the urgency of the problem, these apps have been developed at an accelerated rate with a brief testing period.

View Article and Find Full Text PDF

Recovery-oriented practice has been advocated in mental health services in Hong Kong since 2009. Well-being has become an important area of focus for mental health services. Positive Psychotherapy for Psychosis (PPP) is a well-being-focused intervention for use in psychosis, with preliminary evidence from a randomized controlled trial in the United Kingdom of impact on well-being and symptomatology.

View Article and Find Full Text PDF

Acute comparment syndrome (ACS) is a surgical emergency, in which tissue pressure becomes greater than perfusion pressure leading to tissue ischaemia. It is typically a consequence of trauma. We present a case in which a patient suffers blunt trauma to the thigh, but develops ACS 2 years after this injury and consequently endures 10-episodes of ACS (no perciptating event or cause) in the same thigh over 10 years.

View Article and Find Full Text PDF

Abnormal fluid accumulation in tissues, including the life-threatening cerebral and pulmonary edema, is a severe consequence of bacteria infection. Chlamydia (C.) trachomatis is an obligate intracellular gram-negative human pathogen responsible for a spectrum of diseases, causing tissue fluid accumulation and edema in various organs.

View Article and Find Full Text PDF