The study aimed to compare the immune responses of preterm infants receiving a meningococcal B vaccine using either a 2+1 or a 3+1 vaccination schedule while also evaluating the side effects of routine vaccinations.
The research was conducted in an open-label, phase IV study format across six hospitals in the UK, enrolling 129 preterm infants born before 35 weeks gestation.
Results indicated that while both vaccination schedules were effective, the 3+1 schedule led to a significantly higher antibody response against a specific strain compared to the 2+1 schedule, but also resulted in more fever episodes after vaccination.