Impact of Local Extent of Tumor on the Survival Outcomes for Surgically Treated Tongue Cancers.

Background: The current classification of tongue cancers does not discriminate stages based on factors of local spread.

Aim: Integrating factors of local spread that impact disease-specific survival (DSS) in a modified classification to improve prognostication compared with the current staging.

Method: This was a retrospective analysis of 399 previously untreated oral tongue squamous carcinomas operated between 2016 and 2018.

The role of serum S100B and serum thyroid stimulating hormone levels in vitiligo.

Vitiligo is a depigmenting disorder characterized by melanocyte loss, which results in pigment dilution of the skin. Vitiligo is commonly associated with thyroid disorders and thyroid stimulating hormone (TSH) is a sensitive marker to detect thyroid disorders. S100B is damage associated molecular pattern (DAMP) molecule released when there is melanocyte damage.

An comparison of the fracture resistance of MOD inlay restorations using different lithium disilicates.

Objective: The objective of this study was to evaluate and compare the fracture resistance of MOD inlay preparations restored with two different lithium disilicate glass ceramics.

Materials And Methods: Standardized MOD inlay cavities were prepared on 64 human permanent premolar teeth and divided into two groups to be restored with lithium disilicate glass-ceramic materials, i.e.

Osteomyelitis and Septic Arthritis in the Darwin Prospective Melioidosis Study.

Background: Melioidosis is a multisystem infectious disease caused by the environmental bacterium . Osteomyelitis (OM) and septic arthritis (SA) are uncommon primary presentations for melioidosis but important secondary foci, often requiring prolonged therapy and multiple surgeries. We characterized the epidemiology, presentation, treatment, and outcomes of patients from 24 years of the Darwin Prospective Melioidosis Study (DPMS).

Adjuvant Intensity Modulated Radiation Therapy With a Pedicled Flap Reconstruction in Oral Cavity Squamous Cell Carcinomas: Implications on Target Delineation.

Objectives: To address controversies regarding target volume delineation for adjuvant intensity-modulated radiation therapy for oral cavity squamous cell carcinoma with pedicled flap reconstruction and elective nodal irradiation (ENI).

Materials And Methods: During target volume delineation, the primary tumor bed was the pre-surgical gross tumor volume with an additional isotropic margin of 5-10 mm. Additionally, the flap and body tissue junction were given a margin of 5-10 mm (if not already given).

Inducing cylindrical and spherical defocus after implantation with new generation intraocular lenses improves intermediate and near visual acuity.

An induced cylinder and spherical power after implantation with an extended depth of focus (EDOF) and enhanced monofocal intraocular lens (IOL) could improve distance, intermediate (60 cm) and near (40 cm) visual acuity (VA). In this prospective study, forty eyes with Eyhance EDOF IOL (Johnson and Johnson, USA) and 40 eyes with Vivity EDOF IOL (Alcon Laboratories Inc. USA) were included.

Metalloprotease inhibitors regulate biliary progenitor cells through sDLK1 in organoid models of liver injury.

Understanding cell fate regulation in the liver is necessary to advance cell therapies for hepatic disease. Liver progenitor cells (LPC) contribute to tissue regeneration after severe hepatic injury yet signals instructing progenitor cell dynamics and fate are largely unknown. The Tissue Inhibitor of Metalloproteinases, TIMP1 and TIMP3 control the sheddases ADAM10 and ADAM17, key for NOTCH activation.

Prioritization of Surgical, Obstetric, Trauma, and Anesthesia Care in South and Southeast Asian Countries' Health Planning and Policy‑making: SOTA Care Policies in South and Southeast Asia.

Lack of policy prioritization of surgical, obstetric, trauma and anesthesia (SOTA) care in South and Southeast Asian countries could be a potential contributor to limited access to care. To assess the SOTA care prioritization in National Health Policies, Strategies, and Plans (NHPSPs). We analyzed NHPSPs from twelve South and Southeast Asian countries.

Durable Thin-Film DLC on Wafer Surfaces of Gravure Cylinders for Roll-to-Roll Printing of 1-Bit Electrodes and Microtext in Flexible Electronics and Graphic Security.

Diamond-Like Carbon (DLC), a thin-film material, is emerging as a promising alternative for durable surfaces due to its eco-friendly application process. This study evaluated the use of thin-film DLC on the wafer surface of gravure cylinders for roll-to-roll printing of fine-line electrodes and microtext patterns, specifically for applications in flexible electronics and graphics security. Results suggested that using thin film DLC on the wafer surface allows reliable reproduction of isometric grids and line structures with widths of 15, 20, and 30 µm, as well as solid electrodes.

Discovery of a Novel Mutant-Selective Epidermal Growth Factor Receptor Inhibitor Using an Enabled Drug Discovery Platform.

Despite the success of first, second, and third generation epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) for non-small cell lung cancer with classical EGFR mutations (L858R or Exon 19 deletions), disease progression occurs due to the acquisition of T790M and C797S resistance. Herein, we report a physics-based computationally driven lead identification approach that identified structurally unique imidazo[3.2-]pyrazoles as reversible and wild-type-sparing EGFR TKIs of classical mutations bearing both T790M and C797S.

Travoprost Intracameral Implant: A Review on the Novel Treatment Modality for Open-Angle Glaucoma and Ocular Hypertension.

Objective: This article reviews the published data encompassing the development, pharmacology, efficacy, and safety of travoprost, intracameral implant, a treatment for reduction of intraocular pressure (IOP) in patients with open-angle glaucoma (OAG) or ocular hypertension.

Data Sources: A literature search was conducted from drug discovery until September 2024 through PubMed, MEDLINE, and National Institutes of Health Clinical Trials Registry utilizing the following search terms: iDose, travoprost, intracameral implant, OTX-TIC, open-angle glaucoma, and ocular hypertension.

Study Selection And Data Extraction: All relevant English-language studies, or studies that could be appropriately translated into English, containing the pharmacology, pharmacokinetics, safety, and efficacy of travoprost intracameral implant were selected for review.

Locomotor and discriminative stimulus effects of NBOH hallucinogens in rodents.

Despite the efforts of the Drug Enforcement Administration to safeguard the public from hazardous analogs of synthetic hallucinogens, these compounds have increasingly been observed in the illicit drug market. Four novel compounds were found to be similar in structure to the previously described 25X-NBOMe synthetic hallucinogens. These four compounds, 25B-NBOH, 25C-NBOH, 25E-NBOH, and 25I-NBOH were evaluated for their ability to modify spontaneous locomotor activity in mice to obtain dose range and time-course information and were then tested for discriminative stimulus effects similar to the prototypical hallucinogen (-)-2,5-dimethoxy-4-methylamphetamine (DOM).

Trehalose extricates impaired mitochondrial and autophagy dysregulation in patient iPSC-derived macular corneal dystrophy disease model.

Background: Patient-derived induced pluripotent stem cell (iPSCs) represents a powerful tool for elucidating the underlying disease mechanisms. Macular corneal dystrophy (MCD) is an intractable and progressive bilateral corneal disease affecting the corneal stroma due to mutation/s in carbohydrate sulfotransferase 6 (CHST6) gene. The underlying molecular mechanisms leading to MCD are unclear due to a lack of human contextual model and limited access to affected corneal stromal keratocytes (CSKs) from MCD patients.

Synergistic effects of vitamin C mitigates sodium fluoride-induced dental fluorosis and allergic immune responses in mice.

Fluoride consumption through food and drinking water above permissible levels poses serious health risks. Managing fluoride intake from community water sources is a considerable challenge. This study aimed to understand the synergistic effect of vitamin C supplementation in a mouse model exposed to sodium fluoride (NaF) and ovalbumin (OVA) allergen.

Multimodal Imaging in Unilateral Acute Idiopathic Maculopathy with Infection.

Purpose: To report the multimodal imaging findings in the case of unilateral acute idiopathic maculopathy (UAIM) associated with infection in a young girl with good clinical outcome.

Methods: Rare case report with multimodal imaging including fundus photography, optical coherence tomography (OCT), autofluorescence, multicolor imaging, OCT angiography, fluorescein angiography (FA), and polarization sensitive OCT (PS-OCT).

Results: A 13-year-old girl presented with blurring of vision in the left eye (OS).

Decontaminating the surfaces of bonded screw-retained implant prostheses: A comparison of three different post-processing cleaning techniques.

Statement Of Problem: Bonded screw-retained implant-supported prostheses may become contaminated during fabrication, leading to biological complications. Studies supporting effective cleaning methods are sparse.

Purpose: The purpose of this in -vitro study was to compare the effectiveness of 3 different cleaning techniques for the removal of contaminants on the surfaces of bonded screw-retained implant-supported prostheses.

Cross-cultural adaptation and reliability of patient asthma knowledge questionnaire in the regional Indian language Marathi: a cross-sectional study.

Introduction: patient education is the cornerstone of the clinical management of bronchial asthma. The patient asthma knowledge questionnaire is a valid and reliable tool to assess the disease specific knowledge in the patients with bronchial asthma. To the best of our knowledge and literature search, there is no tool available in Marathi language to assess the knowledge of bronchial asthma in patients.

A Rare Case of Meningitis: Can Cellulosimicrobium cellulans Cause Meningitis in a Non-immunocompromised Person?

Infections with Gram-positive soil-dwelling bacterium are sporadic. Rarely, do patients with indwelling medical devices or those who suffer from immunosuppression get infected by this pathogen. However, based on routine clinical and laboratory procedures, it is hard to distinguish between the meningitis caused by and that from other bacteria.

Comparative Evaluation of Fracture Resistance in Different Post and Core Systems with Varying Ferrule Locations: An Study.

Aim: Endodontically treated teeth often require 360° ferrule to retain post and core restoration. The literature support on scientific evidence of partial ferrule is limited, hence this study was conducted to evaluate the fracture resistance of two post and core systems, i.e.

Chemical characterization of hibiscus rosa-sinensis plant fibers facilitated through design of experiments and artificial neural network hybrid approach.

The integration of natural fibers into Fiber Reinforced Polymers (FRPs) has emerged as a promising avenue for sustainable and high-performance composite materials. Natural fibers, derived from plants, offer notable advantages such as renewability, low cost, and environmental friendliness. Among these natural fibers, Hibiscus Rosa-Sinensis (HRS) plant fibers have gained significant attention owing to their widespread availability and unique mechanical properties.