Kinematics and load-sharing of an anterior thoracolumbar spinal reconstruction construct with PEEK rods: An in vitro biomechanical study.

Background: Polyetheretherketone rod constructs provide adequate spinal stability. Kinematics and load sharing of anterior thoracolumbar reconstruction with polyetheretherketone rods under preload remains unknown.

Methods: Eight human cadaveric specimens (T11-L3) were subjected to a pure moment of 5.

Biomechanical comparison of transfacet screws to lateral mass screw-rod constructs in the lower cervical spine.

Purpose: Transfacet screws have been used as an alternative posterior fixation in the cervical spine. There is lack of spinal stability of the transfacet screws either as stand-along constructs or combined with anterior plate. This study was designed to evaluate spinal stability of transfacet screws following posterior ligamentous injury and combined with anterior plate, respectively, and compare transfacet screws to lateral mass screw-rod constructs.

Mir-664 promotes osteosarcoma cells proliferation via downregulating of FOXO4.

Background: Uncontrol cell growth and proliferation is acknowledged to responsible for cancer-related deaths by disorganizing the balance of growth promotion and growth limitation. Aberrant expression of microRNA play essential roles in cancer development, leads to cell proliferation, growth and survival, and promotes the development of various human tumors, including osteosarcoma. Elucidating the molecular mechanism of this abnormality in osteosarcoma carcinogenesis may improve diagnostic and therapeutic strategies for this malignancy.