Buckyballs to fight pandemic: Water-soluble fullerene derivatives with pendant carboxylic groups emerge as a new family of promising SARS-CoV-2 inhibitors.

Herein, we present the first experimental study of individual water-soluble fullerene derivatives proving their ability to inhibit SARS-CoV-2 in vitro. The initial screening allowed us to identify a few new compounds that have demonstrated pronounced antiviral activity with IC values as low as 390 nM and selectivity indexes reaching 214. Time-of-addition analysis and molecular docking results suggested that the viral protease and/or the spike protein are the most probable targets inhibited by the fullerene derivatives.

[Clinical efficacy of carbohydrate preloading in reconstructive esophageal surgery].

Objective: To evaluate clinical efficacy of preoperative carbohydrate loading as a component of ERAS in esophageal reconstructive surgery.

Material And Methods: Post hoc analysis included 162 patients who underwent esophageal reconstructive interventions with ERAS principles between 2014 and 2024. The main group (=61, CHO+) included patients who were metabolically loaded with carbohydrates in preoperative period with 12.

Asymptomatic cholecystitis and its controversial issues in biliary surgery.

Gallbladder stones are present in 10-20 % of the population of Western countries, and the incidence rate has almost tripled over the past 30 years. Asymptomatic cholecystitis is more common than it is mentioned in the literature. Approximately 80 % of the GI have no clinical manifestations.

Piezoceramics Actuator with Attached Mass for Active Vibration Diagnostics of Reinforced Concrete Structures.

One of the effective methods of non-destructive testing of structures is active vibration diagnostics. This approach consists of the local dynamic impact of the actuator on the structure and the registration of the vibration response. Testing of massive reinforced concrete structures is carried out with the use of actuators, which are able to create sufficiently high-impact loads.

Synthesis of -symmetrical C tetra-adducts reactions of CCl with CH-acids and enol silyl ester.

Here we report the synthesis of novel fullerene derivatives with attached aliphatic residues based on the previously unknown reactions of chlorofullerene CCl with CH-acids and silyl enol ether.

[Eduard Nikitich Vantsian: to the 100th anniversary of the birth].

One hundred and one years ago Eduard Nikitich Vantsyan (1921-1989), an outstanding Soviet surgeon, B.V. Petrovsky's pupil, Doctor of Medicine, Professor, Corresponding Member of the USSR Academy of Medical Sciences, was born (Fig.

Paramagnetic {[Fe(CO)]-μ-η:η-η:η-(C)} Dimer Bridged by Iron Atoms and C-C Bonds: Effect of Starting Iron Carbonyls on Structures and Properties of Negatively Charged Iron-Bridged Fullerene Dimers.

The reaction between an excess of Fe(CO) with {Cryptand(K)}(C) produced the salt {Cryptand(K)}{[Fe(CO)]-μ-η:η-η:η-(C)}·4CHCl () containing negatively charged iron-bridged fullerene dimers. In these dimers, the C cages are linked via two Fe(CO) fragments, forming short Fe-C(C) bonds with a length of 2.070(3) Å and via two intercage C-C bonds with a length of 1.

Nanocomposite Polymer Gel Electrolyte Based on TiO Nanoparticles for Lithium Batteries.

In this article, the specific features of competitive ionic and molecular transport in nanocomposite systems based on network membranes synthesized by radical polymerization of polyethylene glycol diacrylate in the presence of LiBF, 1-ethyl-3-methylimidazolium tetrafluoroborate, ethylene carbonate (EC), and TiO nanopowder (d~21 nm) were studied for H, Li, B, C, and F nuclei using NMR. The membranes obtained were studied through electrochemical impedance, IR-Fourier spectroscopy, DSC, and TGA. The ionic conductivity of the membranes was up to 4.

Magnetic behavior and ground spin states for coordination {L·[M(Hal)]} assemblies (Hal = Cl or I) of radical trianion hexacyanohexaazatriphenylenes (L) with three coordinated high-spin Fe ( = 2) or Co ( = 3/2) centers.

A series of trianion assemblies of hexaazatriphenylenehexacarbonitrile {HAT(CN)} and hexaazatrinaphthylenehexacarbonitrile {HATNA(CN)} with three Fe(II) or Co(II) ions: {cryptand(K)}·{HATNA(CN)·(FeI)}·2CHCl (1), {cryptand(K)}·{HATNA(CN)·(CoI)}·2CHCl (2), and (CV)·{HAT(CN)·(CoCl)}·0.5(CVCl)·2.5CHCl (3) are synthesized (CVCl = crystal violet).

Anthraquinone-Quinizarin Copolymer as a Promising Electrode Material for High-Performance Lithium and Potassium Batteries.

The growing demand for cheap, safe, recyclable, and environmentally friendly batteries highlights the importance of the development of organic electrode materials. Here, we present a novel redox-active polymer comprising a polyaniline-type conjugated backbone and quinizarin and anthraquinone units. The synthesized polymer was explored as a cathode material for batteries, and it delivered promising performance characteristics in both lithium and potassium cells.

New Network Polymer Electrolytes Based on Ionic Liquid and SiO Nanoparticles for Energy Storage Systems.

Elementary processes of electro mass transfer in the nanocomposite polymer electrolyte system by pulse field gradient, spin echo NMR spectroscopy and the high-resolution NMR method together with electrochemical impedance spectroscopy are examined. The new nanocomposite polymer gel electrolytes consisted of polyethylene glycol diacrylate (PEGDA), salt LiBF and 1-ethyl-3-methylimidazolium tetrafluoroborate (EMIBF) and SiO nanoparticles. Kinetics of the PEGDA matrix formation was studied by isothermal calorimetry.

New Hybrid Tetrahydropyrrolo[3,2,1-]quinolin-1-ylidene-2-thioxothiazolidin-4-ones as New Inhibitors of Factor Xa and Factor XIa: Design, Synthesis, and In Silico and Experimental Evaluation.

Despite extensive research in the field of thrombotic diseases, the prevention of blood clots remains an important area of study. Therefore, the development of new anticoagulant drugs with better therapeutic profiles and fewer side effects to combat thrombus formation is still needed. Herein, we report the synthesis and evaluation of novel pyrroloquinolinedione-based rhodanine derivatives, which were chosen from 24 developed derivatives by docking as potential molecules to inhibit the clotting factors Xa and XIa.

Water-Soluble Fullerene C Derivatives Are Effective Inhibitors of Influenza Virus Replication.

The influenza virus genome features a very high mutation rate leading to the rapid selection of drug-resistant strains. Due to the emergence of drug-resistant strains, there is a need for the further development of new potent antivirals against influenza with a broad activity spectrum. Thus, the search for a novel, effective broad-spectrum antiviral agent is a top priority of medical science and healthcare systems.

A regioselective step-by-step CCl functionalization approach affords a novel family of CArTh'Th''H fullerene derivatives with promising antiviral properties.

We report a novel reaction of the recently discovered family of fullerene derivatives -CArTh' with thiophene derivatives Th''H yielding a previously unknown family of -CArTh'Th''H compounds with three different types of functional aromatic addends attached to the carbon cage. The discovered reaction paves a way to the synthesis of novel C fullerene derivatives with promising antioxidant and antiviral properties.

Draft Genome Sequence of Lactococcus lactis Strain 12-16-PSH, Isolated from Prostokvasha from the Arkhangelsk Region of Russia.

A draft genome sequence of Lactococcus lactis strain 12-16-PSH, which was isolated from prostokvasha, is reported. The genome assembly of strain 12-16-PSH contained 63 contigs, with a total length of 2,468,647 bp. A total of 2,421 protein-coding genes were predicted, among which 6 encoded bacteriocins while 15 encoded glycosyl transferases, presumably involved in exopolysaccharide biosynthesis.

[Enteral nutrition in postoperative rehabilitation after reconstructive esophageal and gastric surgery].

Objective: To investigate enteral nutrition as a component of postoperative rehabilitation after reconstructive esophageal and gastric surgeries.

Material And Methods: The study included 217 patients who underwent reconstructive esophageal and gastric surgeries between 2010 and 2020. In the main group (=121), patients underwent postoperative enhanced recovery program (ERAS).

Inner southern magnetosphere observation of Mercury via SERENA ion sensors in BepiColombo mission.

Mercury's southern inner magnetosphere is an unexplored region as it was not observed by earlier space missions. In October 2021, BepiColombo mission has passed through this region during its first Mercury flyby. Here, we describe the observations of SERENA ion sensors nearby and inside Mercury's magnetosphere.

Negatively Charged Iron-Bridged Fullerene Dimer {Fe(CO)-μ-η,η-C}.

The interaction of {Cryptand(K)}(C) with Fe(CO) produced {Cryptand(K)}{Fe(CO)--,-C}·2.5CHCl () as the first negatively charged iron-bridged fullerene C dimer. The bridged iron atoms are coordinated to two 6-6 bonds of one C hexagon with short and long C(C)-Fe bonds with average lengths of 2.

Microbial Communities of Artisanal Fermented Milk Products from Russia.

Fermented milk products (FMPs) have numerous health properties, making them an important part of our nutrient budget. Based on traditions, history and geography, there are different preferences and recipes for FMP preparation in distinct regions of the world and Russia in particular. A number of dairy products, both widely occurring and region-specific, were sampled in the households and local markets of the Caucasus republics, Buryatia, Altai, and the Far East and European regions of Russia.

Effect of the Solvate Environment of Lithium Cations on the Resistance of the Polymer Electrolyte/Electrode Interface in a Solid-State Lithium Battery.

The effect of the composition of liquid electrolytes in the bulk and at the interface with the LiFePO cathode on the operation of a solid-state lithium battery with a nanocomposite polymer gel electrolyte based on polyethylene glycol diacrylate and SiO was studied. The self-diffusion coefficients on the 7Li, 1H, and 19F nuclei in electrolytes based on LiBF and LiTFSI salts in solvents (gamma-butyrolactone, dioxolane, dimethoxyethane) were measured by nuclear magnetic resonance (NMR) with a magnetic field gradient. Four compositions of the complex electrolyte system were studied by high-resolution NMR.

Recent Advances on Membranes for Water Purification Based on Carbon Nanomaterials.

Every year the problem of water purification becomes more relevant. This is due to the continuous increase in the level of pollution of natural water sources, an increase in the population, and sharp climatic changes. The growth in demand for affordable and clean water is not always comparable to the supply that exists in the water treatment market.

[Influence of therapeutic exercises and hardware massage in electrostatic field on lung damage in patients with novel coronavirus pneumonia].

Objective: To analyze the efficacy and safety of therapeutic exercises and chest hardware massage in electrostatic field in patients with COVID-associated viral pneumonia.

Material And Methods: We retrospectively analyzed 1551 patients admitted to the Clinical Hospital No. 1 (MEDSI Group JSC) with COVID-associated pneumonia between April 01, 2020 and June 15, 2021 (ICD-10 U07.

[The role of systemic ozone therapy in the rehabilitation of patients after COVID-19].

Objective: To evaluate the effectiveness and safety of ozone therapy in rehabilitation of patients with previous COVID-19.

Material And Methods: A randomized controlled clinical trial included 51 patients aged 29 - 78 years with SARS-CoV-2 pneumonia (J12.8).