Iron, copper, and zinc concentrations in normal skin and in various nonmalignant and malignant lesions.

The concentrations of zinc (Zn), copper (Cu), and iron (Fe) in the skin have been noninvasively determined in vivo by diagnostic x-ray spectrometry. The skin of healthy controls was divided into two major groups based upon the distribution of the concentrations of these elements. In the face and upper neck, the following wet weight concentrations were recorded: Fe, 14.

[The tendon test of the tibial nerve in Hansen's disease].

Seventeen patients, presenting Hansen's disease, were studied by the Tendon-test. Nine presented pathological answers and 4 did not answer at all, probably due to serious damage. So the amount of pathological answers reached to 76.

Lack of wrinkle formation in the fingertips of patients with Hansen's disease. Confirmation of previous observations.

Immersion of a hand in water at 38-40 degrees C for half an hour was performed in two phases with a one year interval in 38 patients with Hansen's disease and 20 controls. In all 20 controls wrinkles were produced. However, 32 of the 38 patients failed to show wrinkles in the fingertips.

[Hansen's disease and cancer].

The number of patients treated for hanseniasis and cancer in Israel is not sufficient for a statistical analysis. A general conclusion about the incidence of cancer in hanseniasis patients has not been reached. The data presented may be perhaps useful for a comparison with those of other researchers interested in the subject.

Iron content of skin before and after thalidomide treatment of lepra reaction. A preliminary report.

THe concentration of copper, zinc and iron in the skin of patients suffering from lepra reaction was measured by diagnostic X-ray spectrometry (DXS) at the sites of the lesions before and after treatment with thalidomide. The results were compared with the levels of these elements in the skin of healthy individuals. No significant changes in the copper level of leprous skin were found.

In vivo measurements of iron, copper and zinc in the skin of prurigo nodularis patients treated with thalidomide.

The concentration of iron, cooper and zinc in the skin of patients with prurigo nodularis was measured by diagnostic X-ray spectrometry before and after treatment with thalidomide. Before treatment, larger skin lesions were associated with significantly higher zinc levels and higher iron levels than the smaller ones. Upon treatment the zinc and iron content in these lesions decreased towards normal range.

[Absence of the formation of wrinkles of the finger tips in leprosy].

Soaking of the hand of leprosy patients in water of 38 degrees--40 degrees C during half an hour does not lead to the formation of wrinkles, in contrast to healthy individuals. We tend to relate this lack of wrinkles to the damaged nerve ends which are often found in leprosy patients. The number of investigated individuals is small and repeated experiments are therefore required.

Psoriasis and other common dermatoses in leprosy.

The medical records of all 309 leprosy patients who have been under the care of the Government Hospital for Hansen's disease in Jerusalem, Israel during the last 30 years, were surveyed. None of the patients showed clinical evidence of psoriasis on numerous examinations conducted during periods of follow-up of up to more than 4 decades. If this finding proves to be reproducible also in other groups of leprosy patients in other regions of the world, this would suggest that psoriasis is very rare among leprosy patients and that psoriatic subjects might have a natural protection against the development of leprosy.

[Motor-conduction velocity of cubital nerves in patients with leprosy reactions. Summary of a 13-year observation series during thalidomide therapy].

The motor conduction velocity of the ulnar nerves was examined repeatedly in 34 patients with lepromatous leprosy. In patients with active lesions the reduction in velocity paralleled clinical deterioration. In "burned-out" control patients, who had never suffered from leprosy reaction, the conduction velocity remained slow and unchanged over many years.

In vivo study of trace elements in leprous skin.

The skin of leprous patients at various stages of the disease was investigated by diagnostic x-ray spectrometry, In the active stage raised iron and slightly raised zinc levels were found. The usefulness of the method in skin investigation is foreseen.

[World survey on the use of thalidomide in leprosy reaction].

Review of the answers of a questionary sent to 62 different Leprosy Departments. The results indicate that in 99% of lepromatous patients with lepra-reactions, the response to thalidomide was satisfactory. In the tuberculoid and borderline types of lepra, the results were not good.