Cell proliferation in the brains of NMDAR NR1 transgenic mice.

We have used genetically engineered NMDA receptor NR1+/- mice in which the gene for the NR1 subunit was modified in such a way that these mice express only 50% of the NR1 subunit. The NR1 subunit is necessary for NMDA receptor channel function. We investigated the effects of reduced NMDA receptor function on cell proliferation in the hippocampus and the amygdala of the adult mouse brain.