Publications by authors named "Sherri D Hochstetler"
Introduction: Recently, the O-6-methylguanine-DNA methyltransferase (MGMT) locus was proposed as influencing the risk of Alzheimer's disease (AD) in women who did not carry the apolipoprotein E ε4 allele. We examined an Amish founder population for any influence of genetic variation in and around the MGMT locus on the risk for dementia.
Methods: Genetic association was performed for single nucleotide polymorphisms (SNPs) surrounding the MGMT locus.
Article Synopsis
- Researchers are trying to find out how genetics can help protect the brain from Alzheimer's disease (AD) as there aren't many treatments available.
- They studied a group of 946 Amish people aged 76-95 to look for specific genetic markers that might be linked to better brain function.
- They discovered over 100 genetic markers related to cognitive health, with one important marker on chromosome 2 that affects certain brain genes, which might help in finding new treatments.
Introduction: Alzheimer disease (AD) remains a debilitating condition with limited treatments and additional therapeutic targets needed. Identifying AD protective genetic loci may identify new targets and accelerate identification of therapeutic treatments. We examined a founder population to identify loci associated with cognitive preservation into advanced age.
View Article and Find Full Text PDFAlzheimer disease (AD) is the most common type of dementia and is estimated to affect 6 million Americans. Risk for AD is multifactorial, including both genetic and environmental risk factors. AD genomic research has generally focused on identification of risk variants.
View Article and Find Full Text PDFArticle Synopsis
- Researchers studied memory and thinking problems related to Alzheimer's disease using a group of older Amish people to find out more about it.
- They created different ways to define how well people remember things and how those definitions matched with medical classifications and genes.
- The study found that certain groups of people had worse memory and were more likely to show signs of Alzheimer's, which could help identify protective genes in the future.
Alzheimer disease (AD) is the most common type of dementia and is currently estimated to affect 6.2 million Americans. It ranks as the sixth leading cause of death in the United States, and the proportion of deaths due to AD has been increasing since 2000, while the proportion of many other leading causes of deaths have decreased or remained constant.
View Article and Find Full Text PDFIntroduction: Studies of cognitive impairment (CI) in Amish communities have identified sibships containing CI and cognitively unimpaired (CU) individuals. We hypothesize that CU individuals may carry protective alleles delaying age at onset (AAO) of CI.
Methods: A total of 1522 individuals screened for CI were genotyped.