Machine learning-based prediction of disease progression in primary progressive multiple sclerosis.

Primary progressive multiple sclerosis (PPMS) affects 10-15% of multiple sclerosis patients and presents significant variability in the rate of disability progression. Identifying key biological features and patients at higher risk for fast progression is crucial to develop and optimize treatment strategies. Peripheral blood cell transcriptome has the potential to provide valuable information to predict patients' outcomes.

Association of Safety-Net hospital status and hospital outcomes following ACDF or PCDF for CSM.

Introduction: Safety net hospitals (SNH) serve a large proportion of patients with Medicaid or without insurance. However, few prior studies have addressed the impact of SNH status on outcomes following anterior cervical discectomy and fusion (ACDF) or posterior cervical decompression and fusion (PCDF) for cervical spondylotic myelopathy (CSM). The aim of this study was to assess the association between SNH status outcomes following ACDF or PCDF for CSM.

Factors Associated With Depression in Caregivers of Adults With Down Syndrome.

Background: Family caregivers of those with developmental disabilities have higher rates of depression and anxiety compared with caregivers of those without development disability. Few studies have examined factors that contribute to caregiver depression, including the appraisal of caregiving responsibilities and the physical fitness and daily function of the care recipient. The purpose of this study was to identify intrapersonal (caregiver) and interpersonal (care recipient) factors associated with depressive symptoms in caregivers of adults with Down syndrome (DS).

Enhancing thrombectomy outcomes with Adaptive Pulsatile Aspiration (APA): the role of complete clot ingestion in reducing thrombectomy time and distal embolization.

Background: Complete clot ingestion (CCI) is defined as full ingestion of the clot into the catheter or pump canister without any external clot remnants at the catheter tip. The aim of this study was to demonstrate that using the CCI metric in vitro, partially ingested ('corked') clots pose a higher risk of distal emboli given distal emboli may exist in the setting of Thrombolysis In Cerebral Infarction 3 (TICI 3) revascularization.

Methods: Thrombectomies using an in vitro synthetic clot analog were conducted across six catheters using the novel ALGO Smart Pump with Adaptive Pulsatile Aspiration (APA) (Von Vascular Inc, Sunrise, FL) and compared against the Penumbra static Engine Pump (Alameda, CA).

The adaptation of the GameSquad exergaming intervention for young adults with Down syndrome: A pilot feasibility study.

Background: Exergames may be a feasible alternative to in-person exercise that is adaptable for adults with Down Syndrome (DS).

Objective: The purpose of this study was to conduct a 12-week pilot trial to assess the feasibility of exergames for adults with DS.

Methods: Adults with DS were provided Ring Fit Adventure™ which uses a resistance ring and body weight to perform cardiovascular and strength exercises.

Feasibility and preliminary efficacy of a skill-based lifestyle intervention for enhancing cooking abilities and physical fitness in young adults with intellectual disabilities.

Background: Individuals with intellectual disabilities (ID) often experience poorer diet quality and lower physical fitness levels as they transition from adolescence to adulthood.

Objective: The purpose of this study was to assess the initial feasibility and efficacy of Chef-ID, a 12-week intervention designed to improve cooking skills and physical function in young adults with ID.

Methods: Young adults with ID attended weekly group sessions which provided hands-on cooking skills, nutrition education, and exercise.

Diabetes Care in the School Setting: A Statement of the American Diabetes Association.

Diabetes is a prevalent chronic disease in school-age children. To keep students with diabetes safe at school, support their long-term health, prevent complications, and ensure full participation in all school activities, proper monitoring of and response to glucose levels must be attended to throughout the school day and during all school-sponsored activities. Care coordination among the family, school, and diabetes health care professionals is critical.

Reimagining Kangaroo Care for Preterm Infants: A Novel Garment for Safe and Comfortable Bonding.

Background/objectives: Kangaroo Care (KC) has been proven to enhance physiological stability, growth, and bonding in preterm, low-birthweight infants. Despite its benefits, KC is underutilized in Level IV Neonatal Intensive Care Units (NICUs) due to challenges in managing medical equipment. This study introduces the Kangarobe™, a novel garment designed to facilitate safe, comfortable, and efficient KC for medically fragile infants in high-acuity NICUs.

Surgical Therapy of Gastric Ulcer Disease.

Medical advancements, including Helicobacter pylori eradication and antisecretory agents, have reduced peptic ulcer disease (PUD)-associated hospital admissions, mortality, and surgical interventions over the past 30 years. Surgery plays an important role in the treatment of life-threatening complications of PUD, such as bleeding, perforation, and gastric outlet obstruction, as well as for disease that is refractory to medical management. The article highlights the critical role of surgery in cases where medical therapy is insufficient or in the event of emergency complications arising from PUD.

An evaluation of a student-led nursing leadership symposium.

This paper evaluates an innovative student-led nursing leadership symposium at a Southern California university, specifically designed to bridge educational and practical leadership gaps in nursing with a focus on students from underrepresented groups. Integrating Quality and Safety Education for Nurses (QSEN) competencies, the symposium encouraged active participation, self-reflection, and teamwork. It featured interactive panel discussions with nurse leaders and collaborative learning opportunities aimed at developing leadership knowledge, skills, and action.

There is nothing WEIRD about basic research: The critical role of convenience samples in psychological science.

Attention to issues of sample diversity and generalizability has increased dramatically in the past 15 years, as psychological scientists have confronted the limitations of relatively homogeneous samples. Though this reckoning was perhaps overdue and has undoubtedly shined a light on some poor research practices, recommendations surrounding sample diversity are sometimes applied to research that does not aim for generalizability across peoples. In this article, I seek to promote discussion about when and why sample diversity and generalizability matter.

Altered Spike Immunoglobulin G Fc N-Linked Glycans Are Associated With Hyperinflammatory State in Adult Coronavirus Disease 2019 and Multisystem Inflammatory Syndrome in Children.

Background: Severe coronavirus disease 2019 (COVID-19) and multisystem inflammatory syndrome (MIS-C) are characterized by excessive inflammatory cytokines/chemokines. In adults, disease severity is associated with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-specific immunoglobulin G (IgG) Fc afucosylation, which induces proinflammatory cytokine secretion from innate immune cells. This study aimed to define spike IgG Fc glycosylation following SARS-CoV-2 infection in adults and children and following SARS-CoV-2 vaccination in adults and the relationships between glycan modifications and cytokines/chemokines.

Dural manipulation coinciding with transient asystole during lumbar spine surgery: illustrative case.

Background: Hemodynamic disturbances during lumbar spine surgeries have proven to be exceptionally rare, with only seven published cases demonstrating instances where intraoperative dural manipulation coincided with bradycardia, hypotension, and/or asystole.

Observations: The authors present the case of a 39-year-old male with a history of chronic low-back pain and leg weakness. Imaging demonstrated a disc herniation at L5-S1, resulting in impingement of the left S1 traversing nerve root.

Diabetes and Driving: A Statement of the American Diabetes Association.

Many people with diabetes in the U.S. will seek or currently hold a license to drive.

Disbelief, Distress, & Distrust: Trending Institution Related Emotional Distress During COVID-19.

The COVID-19 pandemic had an unprecedented impact on the well-being of individuals working in the healthcare sector. Though many studies exist that focus on physician and nurse well-being, few have specifically identified stressors that affect professionals working within the end-of-life interdisciplinary team. The primary objective of this study was to expand research on moral distress and clinician well-being to include healthcare professionals working with patients with chronic and life-limiting illnesses during the COVID-19 pandemic.

Associations between adolescent perceived loneliness and hair cortisol concentration.

Introduction: Adolescents experience high levels of loneliness, which is linked to poor health in adulthood. Loneliness may contribute to poor health through chronic dysregulation of the hypothalamic-pituitary-adrenal axis. In this analysis, we examined the associations between survey- and ecological momentary assessment (EMA)-based measures of loneliness and hair cortisol concentrations (HCC) in a sample of 1102 adolescents and assessed sex differences in this relationship.

Measuring the impact of multiple social cues to advance theory in person perception research.

Forming impressions of others is a fundamental aspect of social life. These impressions necessitate the integration of many and varied sources of information about other people, including social group memberships, apparent personality traits, inferences from observed behaviors, and so forth. However, methodological limitations have hampered progress in understanding this integration process.

Measuring environmentally sustainable health care: a scoping review.

Work to reduce environmental pollution from the health system is hampered by an absence of consensus on the definition of environmentally sustainable health care and the relevant measurement needed. This scoping review aims to encourage standardisation across sustainability efforts by examining how environmentally sustainable health care is defined and measured in current literature. We conducted a scoping review to identify candidate publications that included either a definition or description of environmentally sustainable health care or a measurement of the impact of health care on the environment.

Improving sustainability and mitigating the environmental impact of anaesthesia and surgery along the perioperative journey: a narrative review.

Climate change, environmental degradation, and biodiversity loss are adversely affecting human health and exacerbating existing inequities, intensifying pressures on already strained health systems. Paradoxically, healthcare is a high-polluting industry, responsible for 4.6% of global greenhouse gas emissions and a similar proportion of air pollutants.