The histone methyltransferase SET10 participates in a chromatin modulation network crucial for intraerythrocytic development.

The lifecycle progression of the malaria parasite requires precise tuning of gene expression including histone methylation. The histone methyltransferase SET10 was previously described as an H3K4 methyltransferase involved in gene regulation, making it a prominent antimalarial target. In this study, we investigated the role of SET10 in the blood stages of in more detail, using tagged SET10-knockout (KO) and -knockdown (KD) lines.