Substituted Benzimidazole Analogues as Potential α-Amylase Inhibitors and Radical Scavengers.

Benzimidazole scaffolds are known to have a diverse range of biological activities and found to be antidiabetic and antioxidant. In this study, a variety of arylated benzimidazoles - were synthesized. Except for compounds , , , and , all are new derivatives.

Syntheses, in vitro α-amylase and α-glucosidase dual inhibitory activities of 4-amino-1,2,4-triazole derivatives their molecular docking and kinetic studies.

Thirty-three 4-amino-1,2,4-triazole derivatives 1-33 were synthesized by reacting 4-amino-1,2,4-triazole with a variety of benzaldehydes. The synthetic molecules were characterized viaH NMR and EI-MS spectroscopic techniques and evaluated for their anti-hyperglycemic potential. Compounds 1-33 exhibited good to moderate in vitro α-amylase and α-glucosidase inhibitory activities in the range of IC values 2.

2-Aryl benzimidazoles: Synthesis, In vitro α-amylase inhibitory activity, and molecular docking study.

Despite of many diverse biological activities exhibited by benzimidazole scaffold, it is rarely explored for the α-amylase inhibitory activity. For that purpose, 2-aryl benzimidazole derivatives 1-45 were synthesized and screened for in vitro α-amylase inhibitory activity. Structures of all synthetic compounds were deduced by various spectroscopic techniques.

Chemical composition, toxicity and larvicidal activity of the essential oil from the whole plant of Acalypha segetalis from south-west Nigeria.

The chemical composition of the essential oil from the whole plant of Acalypha segetalis Muell. Arg. was analyzed by GC and GC/MS.

Essential oil composition, antibacterial activity and toxicity of the leaves of Tetrapleura tetraptera (Schum. & Thonn.) taubert from Nigeria.

The composition of the essential oil of the leaves of Tetrapleura tetraptera (Schum. & Thonn.) Taubert.