Publications by authors named "Sherif Samer Attalla"
Article Synopsis
- In triple-negative breast cancer (TNBC), there's a problem where a type of immune cell, called CD8 T cells, can't get into the tumors, making treatment harder.
- Researchers studied tumors in mice that were missing a protein called Stat3, which usually helps tumors grow and stay tough against the immune system.
- They found that a protein called Chi3l1 stops T cells from entering tumors, and by removing Chi3l1, more T cells got in, leading to better immune responses and improved cancer treatment outcomes.
The tumor-immune microenvironment (TIME) is a critical determinant of therapeutic response. However, the mechanisms regulating its modulation are not fully understood. HER2Δ16, an oncogenic splice variant of the HER2, has been implicated in breast cancer and other tumor types as a driver of tumorigenesis and metastasis.
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