Publications by authors named "Sherif Abou El-Naga"
Article Synopsis
- - Rhabdomyosarcoma (RMS) is a significant type of soft tissue cancer in children, representing about 7% of pediatric cancers, with cyclophosphamide (CPA) as a main treatment; its effectiveness may be influenced by the CYP3A5 enzyme's genetic variations.
- - A study analyzed 150 pediatric RMS patients, genotyping specific non-functional CYP3A5 SNPs to explore their link to the drug’s efficacy and side effects, revealing that most patients were poor metabolizers.
- - The findings indicated a significant relationship between the CYP3A5 genotypes and the incidence of drug-related toxicity, such as hemorrhagic cystitis and nephrotoxicity, highlighting the importance of CYP
Background: Biobanks have become a powerful tool that fosters biomedical research. The success of biobanks depends upon people's perception and willingness to donate their samples for research. This is the first biorepository in Egypt, hence, little is known about the beliefs and attitudes of parents toward participation.
View Article and Find Full Text PDFBackground: Cerebellar pilomyxoid astrocytomas (PMAs) and intermediate pilomyxoid astrocytomas (IPAs) are collectively called "pilomyxoid-spectrum astrocytomas (PMSAs)." Cerebellar PMSAs are thought to behave more aggressively than pilocytic astrocytomas (PAs). Our objective is to compare PMSAs to PAs in terms of surgical and clinical profiles.
View Article and Find Full Text PDFBackground: Patients with cancer who receive intensive chemotherapeutic regimens are subject to profound immunosuppression and are susceptible to an extended array of pathogens.
Procedure: The infectious causes of symptomatic gastroenteritis as evidenced by diarrhea +/- fever, vomiting, and abdominal colic in children following chemotherapy were prospectively monitored at National Cancer Institute, Cairo University.
Results: A total of 104 diarrhea episodes were recorded in our institution during a 10-month period, of which an infectious cause was detected in 74 (71.