Role of germanium L-cysteine alpha-tocopherol complex as stimulator of some antioxidant defense systems in gamma-irradiated rats.

This study was conducted to evaluate the potency of the newly prepared germanium L-cysteine-alpha-tocopherol complex [germanium dichloro tetrakis (L-cysteinyl-alpha-tocopherol amide) dichloride] as a protective agent against gamma-irradiation-induced free radicals production and liver toxicity. Male Swiss albino rats were injected intraperitoneally with the germanium complex in a concentration of 75 mg kg(-1) body mass per dose, for 6 successive doses, last dose administered twenty minutes pre-exposure to a single dose of whole body y-irradiation of 6.5 Gy.