Purpose: Females living with human immunodeficiency virus (FLWHIV) are at increased risk of cervical cancer and U.S. guidelines, first published in 2009 and updated since then, recommend more frequent screening in this population.
View Article and Find Full Text PDFTrypsin digestion plays a pivotal role in successful bottom-up peptide characterization and quantitation. While denaturants are often incorporated to enhance protein solubility, surfactants are recognized to inhibit enzyme activity. However, several reports have suggested that incorporating surfactants or other solvent additives may enhance digestion and MS detection.
View Article and Find Full Text PDFBackground: The impacts of climate change on planetary health are multifaceted and threaten public health gains made since World War II. Healthcare is the fifth largest global emitter of greenhouse gas emissions, demanding significant efforts to transition to an environmentally sustainable future. Addressing these issues will require collective societal action.
View Article and Find Full Text PDFGenome-wide (GWAS) and copy number variant (CNV) association studies have reproducibly identified numerous risk alleles associated with bipolar disorder (BD), major depressive disorder (MDD), and schizophrenia (SCZ), but biological characterization of these alleles lags gene discovery, owing to the inaccessibility of live human brain cells and inadequate animal models for human psychiatric conditions. Human-derived induced pluripotent stem cells (iPSCs) provide a renewable cellular reagent that can be differentiated into living, disease-relevant cells and 3D brain organoids carrying the full complement of genetic variants present in the donor germline. Experimental studies of iPSC-derived cells allow functional characterization of risk alleles, establishment of causal relationships between genes and neurobiology, and screening for novel therapeutics.
View Article and Find Full Text PDFSituational Judgment Tests (SJTs) have gained popularity and are commonly used as a measurement technique in a variety of professions, particularly those that include hiring, promoting, and professional development. In various educational sectors around the world, SJTs are being utilized as a measure by which to choose individuals who possess the requisite non-academic attributes for the profession. The objective of this review is to identify and analyze the traits that are measured in teacher selection using SJTs, in terms of both broad and narrow traits.
View Article and Find Full Text PDFOnline shaming, where people engage in social policing by shaming perceived transgressions via the internet, is a widespread global phenomenon. Despite its negative consequences, scarce research has been conducted and existing knowledge is largely anecdotal. Using a correlational online survey, this mixed-method study firstly assessed whether moral grandstanding, moral disengagement, emotional reactivity, empathy, social vigilantism, online disinhibition, machiavellianism, narcissism, and psychopathy predict participants' (N = 411; aged 15-78) likelihood to engage in online shaming.
View Article and Find Full Text PDFIntroduction: A traceback genetic testing program for ovarian cancer has the potential to identify individuals with hereditary breast and ovarian cancer and their relatives. Successful implementation depends on understanding and addressing the experiences, barriers, and preferences of the people served.
Methods: We conducted a remote, human-centered design research study of people with ovarian, fallopian tube, or peritoneal cancer (probands) and people with a family history of ovarian cancer (relatives) at three integrated health systems between May and September 2021.
Trauma Violence Abuse
December 2023
Research examining the prevalence and impacts of stalking on mental health professionals (MHPs) has grown over the last two decades. Yet only one previous review has been undertaken examining impacts on staff and focusing on clients as stalkers, with prevalence estimated between 10% and 13%. This systematic review sought to assess prevalence of stalking, and associated impacts and methods of coping reported by MHPs, irrespective of perpetrator type.
View Article and Find Full Text PDFAcalabrutinib is a Bruton tyrosine kinase (BTK) inhibitor approved to treat adults with chronic lymphocytic leukemia, small lymphocytic lymphoma, or previously treated mantle cell lymphoma. As the bioavailability of the acalabrutinib capsule (AC) depends on gastric pH for solubility and is impaired by acid-suppressing therapies, coadministration with proton-pump inhibitors (PPIs) is not recommended. Three studies in healthy subjects (N = 30, N = 66, N = 20) evaluated the pharmacokinetics (PKs), pharmacodynamics (PDs), safety, and tolerability of acalabrutinib maleate tablet (AT) formulated with pH-independent release.
View Article and Find Full Text PDFBackground: Minority blood donation, especially from individuals of African ethnicity, is a focus for many countries with diverse populations. As the need for antigen-negative RBC transfusions for patients with Sickle Cell Disease (SCD) continues to grow, inclusion of more African blood donors is essential to ensure this demand is met.
Materials And Methods: This study aims to explore barriers and motivators to blood donation and awareness of SCD among potential donors of diverse ethnic backgrounds in Ireland.
Aim: To explore newly graduated nurse's understandings and practices of adaptability and resilience in clinical environments.
Background: The everyday practice of nursing work involves managing emotional and practical everyday demands related to the role. Adaptability and resilience are two critical attributes that equip nurses for this by enabling them to manage challenges and be flexible with their practices and expectations in the face of rapidly changing and unpredictable circumstances.
Trauma Violence Abuse
July 2023
In recent years the body of literature on cyberstalking has expanded rapidly. The present work aimed to summarize the current state of the literature on cyberstalking perpetration and victimization in a scoping review. Forty-one quantitative and qualitative studies that examined variables relating to cyberstalking victimization and perpetration were collated.
View Article and Find Full Text PDFResearch in stalking perceptions has shown certain relational biases, in which people tend to view ex-partner stalkers to be less dangerous than stranger or acquaintance stalkers. These findings are in direct contrast to those of real-life cases whereby ex-partner stalkers pose a greater threat. In addition, although stalking is recognized as a global social problem, most studies have been based on samples drawn from Western, educated, industrialized, rich, and democratic countries.
View Article and Find Full Text PDFAbstractIt is known that many domestic violence (DV) offenders also commit violent and nonviolent offences that are not domestic in nature. Stalking frequently evolves from DV contexts. The present study used police data to explore (i) the extent to which stalking offenders in Western Australia specialize in stalking, (ii) the frequency of involvement in DV offending by stalking offenders, and (iii) the types of offences that co-occur with stalking offences.
View Article and Find Full Text PDFThe absence of a widely accepted definition of cyberstalking has resulted in studies operationalizing it in various ways, reducing the comparability and generalizability of findings. The present work examined the most common behaviors and criteria used to operationalize cyberstalking within the quantitative literature. The definitions employed by the studies were evaluated in respect of (a) whether they included a minimum requirement for the number of times the behaviors needed to be repeated in order to be considered "cyberstalking"; (b) whether victim fear was required for the behaviors to be considered "cyberstalking"; (c) the timeframe within which the cyberstalking behavior needed to have occurred; and (d) the behaviors identified as indicating cyberstalking.
View Article and Find Full Text PDFThe criminal offense of stalking is somewhat different to other offenses due to the repetitive, innocuous, and often multifaceted nature of the crime. Given that stalking constitutes a number of different behaviors, such as violence and threats, research on stalking recidivism becomes difficult as recidivism can be defined in a number of ways. This study utilized a dataset of Western Australia Police Force incident reports, comprising a sample of 404 stalking offenders.
View Article and Find Full Text PDFInt J Environ Res Public Health
April 2020
Epidemiological data suggest that as many as 0.66% of adult women and 0.17% of adult men in the western world may suffer the subjective experience of being group-stalked ('gang stalked') at some point in their lives.
View Article and Find Full Text PDFInt J Environ Res Public Health
March 2020
Most studies of stalking and other forms of intrusive behavior are conducted in the West. Little is known about the phenomenon in the African context. The present work represents the first dedicated stalking study conducted in Ghana.
View Article and Find Full Text PDFThe Mood Disorder Questionnaire (MDQ) is an established screening tool for bipolar spectrum disorders (BSD), but has not been validated in diverse populations and the best scoring method remains uncertain. This study assessed diagnostic validity of the MDQ among Anabaptists, an underserved population frequently involved in genetic research. 161 participants completed the MDQ and were diagnosed by a best-estimate final diagnosis (BEFD).
View Article and Find Full Text PDFMost stalking studies are conducted in the West. Limited information is available on victims of stalking from the Asian continent. This study specifically explored the victimization experiences of young male and female adults in Hong Kong.
View Article and Find Full Text PDFUniversities can promote social impact by developing a dementia literate workforce. The Dementia Enabling University Strategy utilised a knowledge translation framework in an Australian university to inspire and support academics to engage students and consider how their skills and knowledge could contribute to the creation of more supportive environments for people with dementia. Dementia Enabling University Strategy ran across eight disciplines: law, media, social sciences, public health, engineering, business, marketing and psychology and was successful in engaging university academics and students.
View Article and Find Full Text PDFJ Interpers Violence
September 2021
Stalkers can be violent, and empirical studies have sought to identify factors associated with violence perpetrated by the stalker. Most of these works view physical violence as a homogeneous construct and do not differentiate between moderate and severe violence. The present study aims to identify correlates of nonviolent, moderate, and severe physical violence within an archival sample of 369 domestically violent police incident reports, where stalking behavior was indicated.
View Article and Find Full Text PDFJ Interpers Violence
August 2021
Stalking is a complex issue involving multiple behaviors and interactions between the stalker and their target. Research has typically involved grouping risk behaviors related to stalking; however, the research question in the current research was to what extent a temporal method would allow investigators to map the dynamics of stalking. Behavior Sequence Analysis is a form of systems analysis that examines sequences of events over time, providing statistically significant results from complex real-world data.
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