Increased MicroRNA-1266 levels as a biomarker for disease activity in psoriasis vulgaris.

Background: Increasing evidence has shown that serum microRNA (miR) levels are useful biomarkers for the diagnosis, prognosis, and therapeutic value in various diseases. Psoriasis is characterized by a specific miR expression profile, with a characteristic miR signature, distinct from that of healthy skin.

Objectives: To understand the role of miR-1266 in the pathogenesis of psoriasis and to explore if it has the potential as a blood biomarker.

Role of the tumor necrosis factor family member LIGHT in the pathogenesis of atopic dermatitis.

Background: LIGHT (the name of which is derived from "homologous to lymphotoxins, exhibits inducible expression, competes with herpes simplex virus glycoprotein D for herpes simplex virus entry mediator, and expressed by T lymphocytes"), is a member of the tumor necrosis factor superfamily that is involved in various inflammatory diseases.

Objectives: To assess serum LIGHT levels in patients with atopic dermatitis (AD) before and after treatment and compare it with controls. To correlate serum LIGHT with the severity scoring of AD (SCORAD) index.