ELISA based seroprevalence and risk factors for three zoonotic parasites (Toxoplasma gondii, Echinococcus granulosus and Trichinella spiralis) in humans in Khyber Pakhtunkhwa, Pakistan.

Zoonotic parasitic infections can affect both animal and human health, while also having food safety and economic implications. These pathogens can also pose occupational risks for certain groups, including veterinary professionals, animal handlers, and butchers. This study was conducted in the district of Swabi located in the Khyber Pakhtunkhwa Province of northwestern Pakistan.

Prostatic Adenocarcinoma in a Patient With a History of Cryptorchidism-Associated Hypogonadism: A Case Report.

Prostate cancer is a prevalent malignancy often associated with advancing age and high androgen levels. Hypogonadism is characterized by low testosterone levels, and as prostate growth is androgen-dependent, this links elevated testosterone to increased prostate cancer risk. This rare presentation of a middle-aged man with the development of prostate cancer, following a history of congenital cryptorchidism and subsequent hypogonadism, challenges the conventional understanding of the role of testosterone in the development of prostate cancer.

Development and detailed investigation of metal nanoparticles decorated carbon black/sodium alginate composite beads for catalytic reduction of environmental toxicants and hydrogen production.

The discharge of environmental pollutants requires intellectual and rapid solutions to convert them into safer products. Simultaneously, the high energy demands underscore the imperative importance of generating sufficient green energy to fulfill human needs. This study focused on metal nanoparticles (MNPs) decoration on polymeric beads (BDs), employing orange peel derived carbon black (OrP) and sodium alginate polymer (Alg).

Role of metformin in male oxidative stress infertility (MOSI): An in vitro experimental study.

The study aimed to determine the in-vitro effect of metformin on total antioxidant capacity (TAC) of seminal samples of infertile male subjects. It was conducted from January to June 2022 on forty-four seminal plasma samples collected from male infertile patients, age ranging from 18 to 55 years. All 44 semen samples were treated as three distinct groups: (i) a control group (ii) a study group subjected to oxidative stress (OS) induction and (iii) a test group exposed to OS induction and subsequent treatment with metformin.

Gluconeogenesis unraveled: A proteomic Odyssey with machine learning.

The metabolic pathway known as gluconeogenesis, which produces glucose from non-carbohydrate substrates, is essential for maintaining balanced blood sugar levels while fasting. It's extremely important to anticipate gluconeogenesis rates accurately to recognize metabolic disorders and create efficient treatment strategies. The implementation of deep learning and machine learning methods to forecast complex biological processes has been gaining popularity in recent years.

Novel chiral phthalimides: Antimicrobial evaluation and docking study against Acinetobacter baumannii's OmpA protein.

Antibiotics have been a vital component in the fight against microbial diseases for over 75 years, saving countless lives. However, the global rise of multi-drug-resistance (MDR) bacterial infections is pushing us closer to a post-antibiotic era where common infections may once again become lethal. To combat MDR Acinetobacter baumannii, we investigated chiral phthalimides and used molecular docking to identify potential targets.

Fermatean fuzzy Linguistic term set based on linguistic scale function with Dombi aggregation operator and their application to multi criteria group decision -making problem.

The selection of an industrial location is a challenging multiple-criteria decision-making (MCDM) problem that depends on taking a variety of locations as well as incompatible and inconsistent criteria. This paper proposed a comprehensive framework for the strategic selection of industrial locations, considering both quantitative and qualitative aspects. Decision-makers (DMs) have to deal with ambiguous information throughout this process due to a complex decision environment or their insufficient knowledge.

Correlation Between Ischemia Time and Left Ventricular Failure After Primary Percutaneous Coronary Intervention in ST-Elevation Myocardial Infarction (STEMI) Patients.

Background: Primary percutaneous coronary intervention (PPCI) is pivotal in treating ST-elevation myocardial infarction (STEMI) patients, yet ischemia time significantly impacts outcomes, particularly left ventricular failure (LVF).

Objective: This study aimed to investigate the impact of ischemia duration and other variables associated with severe left ventricular systolic dysfunction in STEMI patients receiving PPCI treatment.

Methodology: This prospective cohort was carried out at Lady Reading Hospital in Peshawar, Pakistan, from January to June 2023.

Efficacy of activated carbon using Salvadora persica stem for remediation of potentially toxic dyes from aqueous solution.

Potentially toxic dyes are introduced mainly to rivers through industrial effluents which have a high risk to human health and aquatic life. Activated carbon (AC) from the stem of Salvadora persica was synthesised to take off toxic industrial dyes from an aqueous solution. KOH was used as the activating agent throughout the preparation process for the AC.

Variants in HCFC1 and MN1 genes causing intellectual disability in two Pakistani families.

Background: Intellectual disability (ID) is a neurodevelopmental condition affecting around 2% of children and young adults worldwide, characterized by deficits in intellectual functioning and adaptive behavior. Genetic factors contribute to the development of ID phenotypes, including mutations and structural changes in chromosomes. Pathogenic variants in the HCFC1 gene cause X-linked mental retardation syndrome, also known as Siderius type X-linked mental retardation.

Development of silver-doped copper oxide and chitosan nanocomposites for enhanced antimicrobial activities.

Antimicrobial resistance (AMR) has emerged as a significant and pressing public health concern, posing serious challenges to effectively preventing and treating persistent diseases. Despite various efforts made in recent years to address this problem, the global trends of AMR continue to escalate without any indication of decline. As AMR is well-known for antibiotics, developing new materials such as metal containing compounds with different mechanisms of action is crucial to effectively address this challenge.

Radial Artery Occlusion After Transradial Access for Coronary Interventions.

Background Transradial access (TRA) is a medical procedure primarily used for percutaneous coronary interventions (PCI) and cardiac catheterization. Based on the recently published Minimizing Adverse Haemorrhagic Events by Transradial Access Site and Systemic Implementation of AngioX (MATRIX) trial, TRA is being used more frequently than transfemoral access (TFA) since it has reduced rates of bleeding and fatality. A structural complication of TRA is radial artery occlusion (RAO), which may cause temporary pain to limit TRA in the future.

Effect of ribs in a suddenly expanded flow at sonic Mach number.

This study aims to assess the influence of a rib on the base pressure and the flow development in an abruptly expanded duct at sonic Mach number. Initially, the simulations were done to validate the experimental results, keeping all the parameters the same. Accordingly, a duct-of-area ratio of 6.

Heat Transfer of Ca (NO)-KNO Molten Salt Mixtures for Austempering and Martempering Processes of Steels.

Molten salts are highly effective as a quenching medium for austempering and martempering processes, enabling precise control of cooling rates to achieve the desired microstructures and mechanical characteristics in steel components. One such promising molten salt is a multicomponent Ca (NO)-KNO molten salt. The current work explores the cooling severity of molten Ca (NO)-KNO mixtures, which are commonly used for such purposes.

Metal nanoparticles decorated mint-cellulose acetate composite as an efficient catalyst for the reduction of methyl orange.

Water contamination caused by toxic compounds has emerged as one of the most severe challenges worldwide. Biomass-based nanocomposites offer a sustainable and renewable alternative to conventional materials. In this study, a nanocomposite of mint and cellulose acetate (Mint-CA) was prepared and employed as a supportive material for Cu nanoparticles (CuNPs) and Ag nanoparticles (AgNPs).

Silver oxide doped iron oxide/alginate nanocomposite coated cotton cloth for selective catalytic reduction of potassium ferricyanide.

Silver oxide doped iron oxide (AgO-FeO) nanocatalyst was prepared and coated on cotton cloth (CC) as well as wrapped in sodium alginate (Alg) hydrogel. AgO-FeO coated CC (AgO-FeO/CC) and AgO-FeO wrapped Alg (AgO-FeO/Alg) were utilized as catalysts in reduction reaction of 4-nitrophenol (4-NP), congo red (CR), methylene blue (MB) and potassium ferricyanide (K[Fe(CN)]). AgO-FeO/CC and AgO-FeO/Alg were found to be effective and selective catalyst for the reaction of K[Fe(CN)].

Physiological and biochemical assortment in different wheat genotypes ( L.) under rain fed conditions.

Wheat (Triticum aestivum L.) is the most extensively cultivated cereal crop in the world; however, its growth and development are affected by different types of biotic and abiotic stress conditions. The aim of this study was to assess the physico-chemical diversity in different wheat genotypes under rain-fed conditions.

Chiral phthalimides against penicillin-binding protein 2a of methicillin-resistant : molecular docking and analysis.

() is a commensal bacterium and an opportunistic pathogen causing a wide variety of infections ranging from localized skin and soft tissue infections to life-threatening severe bacteremia, osteomyelitis, endocarditis, atopic dermatitis, prosthetic joint infection, staphylococcal food poisoning, medical device-related infections, and pneumonia. It is attributed to an acquired resistant gene, , encoding penicillin-binding protein 2a (PBP2a). PBP2a is an essential protein responsible for the resistivity of methicillin-resistant (MRSA) to various beta-lactam antibiotics.

Association of maternal, obstetric, fetal, and neonatal mortality outcomes with Lady Health Worker coverage from a cross-sectional survey of >10,000 households in Gilgit-Baltistan, Pakistan.

Pakistan has among the highest rates of maternal, perinatal, and neonatal mortality globally. Many of these deaths are potentially preventable with low-cost, scalable interventions delivered through community-based health worker programs to the most remote communities. We conducted a cross-sectional survey of 10,264 households during the baseline phase of a cluster randomized controlled trial (cRCT) in Gilgit-Baltistan, Pakistan from June-August 2021.

Hypocalcaemia As A Rare Reversible Cause Of Dilated Cardiomyopathy.

Dilated cardiomyopathy is characterized by dilation and enlargement of one or both ventricles with reduced systolic function. Calcium plays a key role in myocardial contraction. Hypocalcaemia can lead to a decrease in contraction, left ventricular systolic dysfunction, and heart failure with reduced ejection fraction (EF).

Catalytic innovations: Improving wastewater treatment and hydrogen generation technologies.

The effective reduction of hazardous organic pollutants in wastewater is a pressing global concern, necessitating the development of advanced treatment technologies. Pollutants such as nitrophenols and dyes, which pose significant risks to both human and aquatic health, making their reduction particularly crucial. Despite the existence of various methods to eliminate these pollutants, they are not without limitations.