Publications by authors named "Shenyuan Guo"
Article Synopsis
- The myelin sheath protects and insulates nerve fibers, allowing for fast signal transmission, heavily relying on mitochondria for energy, with most mitochondrial proteins encoded by nuclear genes.
- A multiomics approach was used to analyze a set of 1,740 nuclear-encoded mitochondrial genes (nMGs) across different species and to study their role in demyelinating diseases by examining their expression in various conditions.
- The study identified 110 specific nMGs linked to energy production and metabolic processes that could further our understanding of myelin-related disorders and potentially lead to new treatment avenues.
The arginine finger of bacteriophage T7 gene 4 helicase: role in energy coupling.
Proc Natl Acad Sci U S A
March 2004
The DNA helicase encoded by gene 4 of bacteriophage T7 couples DNA unwinding to the hydrolysis of dTTP. The loss of coupling in the presence of orthovanadate (Vi) suggests that the gamma-phosphate of dTTP plays an important role in this mechanism. The crystal structure of the hexameric helicase shows Arg-522, located at the subunit interface, positioned to interact with the gamma-phosphate of bound nucleoside 5' triphosphate.
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