Background: Breast cancer is a significant public health issue worldwide, being the most prevalent cancer among women and a leading cause of death related to this disease. The molecular processes that propel breast cancer progression are not fully elucidated, highlighting the intricate nature of the underlying biology and its crucial impact on global health. The objective of this research was to perform bioinformatics analyses on breast cancer-related datasets to gain a comprehensive understanding of the molecular mechanisms at play and to identify key genes associated with the disease.
View Article and Find Full Text PDFOxidative stress (OS)-related genes have been confirmed to be closely related to the prognosis of triple-negative breast cancer (TNBC) patients; despite this fact, there is still a lack of TNBC subtype strategies based on this gene guidance. Here, we aimed to explore OS-related subtypes and their prognostic value in TNBC. Data from The Cancer Genome Atlas (TCGA)-TNBC and Sequence Read Archive (SRA) (SRR8518252) databases were collected, removing batch effects using a combat method before analysis.
View Article and Find Full Text PDFA novel photoelectrochemical (PEC) biosensor based on b-TiO/CdS:Eu/TiC heterojunction was developed for ultrasensitive determination of miRNA-21. In this device, the b-TiO/CdS:Eu/TiC heterojunction with excellent energy level arrangement effectively facilitated photoelectric conversion efficiency and accelerated the separation of the photogenerated electron hole pairs, which because that the structure of heterojunction overcomes the drawbacks of single material, such as narrow light absorption range, wide band gap, short carrier lifetime, etc., improves light utilization, extends the lifetime of photogenerated electron hole pairs, and promotes electron transfer.
View Article and Find Full Text PDFHerein, an ultra-sensitive photoelectrochemical biosensor based on TiC:CdS nanocomposite was established for the selective detection of microRNA159c. TiC:CdS nanocomposites were used as optoelectronic materials because TiC:CdS interaction effectively separates photogenerated electrons and holes, and significantly improves the high photoelectric conversion efficiency. Firstly, TiC:CdS nanocomposite was deposited on the surface of the fluorine-doped tin oxide (FTO) electrode.
View Article and Find Full Text PDFEarth-abundant iron pyrite (FeS2) shows great potential as a light absorber for solar cells and photodetectors due to their high absorption coefficient (>10(5) cm(-1)). In this paper, high-quality phase-pure and single crystalline pyrite nanocrystals were synthesized via facile, low-cost, and environment friendly hydrothermal method. The molar ratio of sulphur to iron and the reaction time play a crucial role in determining the quality and morphology of FeS2 nanocrystals.
View Article and Find Full Text PDFIron pyrite (FeS2) nanostructures are of considerable interest for photovoltaic applications due to improved material quality compared to their bulk counterpart. As an abundant and nontoxic semiconductor, FeS2 nanomaterials offer great opportunities for low-cost and green photovoltaic technology. This paper describes the fabrication of FeS2 nanowire arrays via sulfurization of iron oxide nanotubes at relatively low temperatures.
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