ENO2-derived phosphoenolpyruvate functions as an endogenous inhibitor of HDAC1 and confers resistance to antiangiogenic therapy.

Metabolic reprogramming is associated with resistance to antiangiogenic therapy in cancer. However, its molecular mechanisms have not been clearly elucidated. Here, we identify the glycolytic enzyme enolase 2 (ENO2) as a driver of resistance to antiangiogenic therapy in colorectal cancer (CRC) mouse models and human participants.

An Inductor-Loaded Single-Port Planar Dual-Broadband Antenna with Stable Gains.

A single-port dual-wideband base-station antenna is reported here for mobile communication systems. Loop and stair-shaped structures with lumped inductors are adopted for dual-wideband operation. The low and high bands share the same radiation structure to accomplish a compact design.

Exploring the mechanism of Cassiae semen in regulating lipid metabolism through network pharmacology and experimental validation.

Background: Multiple studies have assessed the role of Cassiae semen (CS) in regulating lipid metabolism. However, the mechanism of action of CS on non-alcoholic fatty liver disease (NAFLD) has seen rare scrutiny.

Objective: The objective of this study was to explore the regulatory mechanism of CS on lipid metabolism in NAFLD.

Refined Dynamic Event-Triggering Cluster Consensus of Multiagent Systems With Fixed/Switching Topology.

This article is concerned with cluster consensus control of multiagent systems (MASs) with the fixed/switching topology under a dynamic event-trigger (DET) mechanism. A refined sampled-data-based DET scheme is proposed by introducing two dynamically adjusting threshold parameters to distinguish the different transmission requirements for neighboring agents intra and outer cluster. Faced with the difficulties of acquiring full state information among spatially distributed agents, output feedback is employed to construct cooperative control protocols.