Ga-fibroblast activation protein inhibitor PET/CT on gross tumour volume delineation for radiotherapy planning of oesophageal cancer.

Background And Purpose: To compare Ga-fibroblast activation protein inhibitor (FAPI) and F-FDG PET/CT in imaging locally advanced oesophageal cancer, and evaluate the potential usefulness of Ga-FAPI PET/CT on gross target volume (GTV) delineation aimed at radiotherapy planning for oesophageal cancer as compared with contrast-enhanced CT (CE-CT) and F-FDG PET/CT.

Materials And Methods: Twenty-one patients with newly diagnosed oesophageal cancer who underwent both F-FDG and Ga-FAPI PET/CT scans were selected. GTVs of the primary tumours based on CE-CT (GTV), PET/CT, and CE-CT plus PET/CT were delineated.