Publications by authors named "Shenhao Huang"

Article Synopsis
  • Persistent gastrointestinal symptoms such as abdominal pain, nausea, and diarrhea may affect some patients after recovering from COVID-19, but the immune response in their gastrointestinal tracts is not well understood.
  • A study examined 95 COVID-19 patients, focusing on 11 with gastrointestinal issues, using advanced imaging techniques to analyze immune cell types and their distribution in the gut tissues.
  • Findings indicated significant inflammation in the duodenum, with increased CD68 macrophages and CD3CD4 T-cells; their interactions differ based on the presence of viral proteins, and specific gene patterns correlated with clinical symptoms and immune responses.
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Underwater light attenuation leads to decreased image contrast. This reduction in contrast subsequently decreases target visibility. Additionally, marine target detection is challenging due to multi-scale problems from varying target-to-device distances, complex target clustering, and noise from waterborne particulates.

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The understanding of DNA-surfactant interactions is important for fundamental physical biology and developing biomedical applications. In the present study, we demonstrated a DNA-surfactant nano-machine model by modulating the compaction of DNA in dodecyldimethylamine oxide (DDAO) solutions. By controlling DDAO concentration and pH of solution, we are able to adjust the compacting force of DNA so as to pull biomolecular subunits connected to it.

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The article entitled, "lncRNA IGF2-AS Promotes Cell Proliferation, Migration, and Invasion of Gastric Cancer by Modulating miR-937/EZH2 Axis," by Zizi Li, Zhanyu Li, Zhijuan Zhong, Jianhui Zhou, Shenhao Huang, Wenying Zhou, and Jianfeng Xu (Cancer Biother Radiopharm epub 25 May 2020; Doi: 10.1089/cbr.2019.

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miR-155 plays critical roles in numerous physiological and pathological processes, however, its function in the regulation of blood glucose homeostasis and insulin sensitivity and underlying mechanisms remain unknown. Here, we reveal that miR-155 levels are downregulated in serum from type 2 diabetes (T2D) patients, suggesting that miR-155 might be involved in blood glucose control and diabetes. Gain-of-function and loss-of-function studies in mice demonstrate that miR-155 has no effects on the pancreatic β-cell proliferation and function.

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