IRF1 transcriptionally up-regulates CXCL10 which increases CD8 T cells infiltration in colorectal cancer.

Tumor-infiltrating CD8 T cell is a robust predictor of outcome and immunotherapy response in patients with CRC. However, limited introduction of intratumoral CD8 T cells remains a barrier for treatment of CRC. One of the most effective but difficult therapy for CD8 T cells entering the tumor is activating chemokine receptors.

Functional evaluation of pure natural edible Ferment: protective function on ulcerative colitis.

Purpose: To investigate the therapeutic efficiency of a novel drink termed "Ferment" in cases of ulcerative colitis (UC) and its influence on the gut microbiota.

Method: In this study, we developed a complex of mixed fruit juice and lactic acid bacteria referred to as Ferment. Ferment was fed to mice for 35 days, before inducing UC with Dextran Sulfate Sodium Salt.

microRNA-622 upregulates cell cycle process by targeting FOLR2 to promote CRC proliferation.

Background: Epigenetic alterations contribute greatly to the development and progression of colorectal cancer, and effect of aberrant miR-622 expression is still controversial. This study aimed to discover miR-622 regulation in CRC proliferation.

Methods: miR-622 expression and prognosis were analyzed in clinical CRC samples from Nanfang Hospital.