Publications by authors named "Shengyu Ye"
Parasit Vectors
October 2024
Article Synopsis
- Schistosoma japonicum infection leads to liver fibrosis, causing significant health issues, with a lack of effective treatments; understanding the role of long non-coding RNAs (lncRNAs) in this condition is crucial for developing therapies and biomarkers.
- A study identified 1561 differentially expressed lncRNAs in hepatic stellate cells from infected mice, with Malat1 being notably downregulated in infected cells; its expression increased significantly after treatment with praziquantel.
- Manipulating Malat1 levels demonstrated that higher Malat1 expression in infected cells reduced fibrosis-associated gene levels, while knocking down Malat1 had the opposite effect, highlighting its potential role in managing liver fibrosis.
