Iron-catalyzed 1,3-dipolar cycloaddition of alkynes and aryl nitrones for the synthesis of chiral Δ-isoxazolines.

The synthesis of chiral Δ-isoxazolines is a crucial area of research due to their biological activity and versatility in synthetic chemistry. Driven by the abundant reserves, low cost and high biocompatibility of iron catalysts, we herein investigated the catalytic potential of iron complexes in asymmetric 1,3-dipolar cycloaddition reactions between N-Bn,α-aryl nitrones and 3-propioloyloxazolidin-2-ones. By utilizing Fe(OTf) and (,)-DBFOX-Ph, a series of ()-Δ-isoxazolines were obtained in high yields (up to 99%) with good to excellent enantioselectivities (up to 98 : 2 er).

Navigating the Path to Food Security in China: Challenges, Policies, and Future Directions.

This paper provides a comprehensive review and an in-depth analysis of the multifaceted issues surrounding food security in China, exploring historical trends, current challenges, and future strategies. Drawing upon a wide range of sources including government reports, the academic literature, and expert analyses, it examines the complex interplay of factors influencing food production, distribution, and consumption in China. The paper highlights the importance of addressing environmental sustainability, technological innovation, and social equity in shaping China's food security agenda.

Intramolecular charge transfer assisted multi-resonance thermally activated delayed fluorescence emitters for high-performance solution-processed narrowband OLEDs.

Multi-resonance thermally activated delayed fluorescence (MR-TADF) emitters have been actively employed in high-resolution solution-processed organic light emitting diodes (OLEDs) due to their excellent color purity. Nonetheless, they are always confronted with intrinsic slow spin flip of triplet excitons, impeding the electroluminescence properties, especially in non-sensitized OLEDs. Herein, we constructed intramolecular charge transfer (ICT) assisted MR-TADF emitters by grafting donor-acceptor-type moieties with a - or -substitution as a pendant on an organoboron multi-resonance core.

Anti-colorectal cancer effect of total minor ginsenosides produced by lactobacilli transformation of major ginsenosides by inducing apoptosis and regulating gut microbiota.

Objective: Minor ginsenosides have demonstrated promising anticancer effects in previous reports. Total minor ginsenosides (TMG) were obtained through the fermentation of major ginsenosides with , and potential anticancer effects of TMGs on the mouse colon cancer cell line CT26.WT, and , were investigated.

Preparation and properties of waterborne polyurethane/nanocellulose/sepiolite composite aerogel for sound absorption and heat insulation.

Faced with all kinds of serious ecological and environmental protection problems in today's society, development must take the sustainable and green road. Nanocellulose aerogels with the advantages of wide resource of raw materials, low cost, good biocompatibility and biodegradation, are good thermal and sound insulation materials. Herein, a versatile composite aerogel with good thermal stability and heat-insulating property was prepared by freeze-drying method using cellulose nanocrystals (CNCs), waterborne polyurethane (WPU) and sepiolite (SEP) as substrates.

Assessment of vegetation restoration potential in central Asia.

Vegetation restoration potential (VRP) assessment is an important aspect and foundation of ecological restoration projects. Neglecting the carrying capacity of the natural environment in the formulation and implementation of ecological restoration projects often leads to diminished effectiveness or even environmental damage. Existing models for VRP either overly rely on empirical knowledge, resulting in low efficiency and reproducibility, or fail to consider the nonlinear relationship between the natural environment and vegetation cover, leading to low accuracy in assessment results.

The Effect of Salt Reduction on the Microbial Community Structure and Metabolite Composition of Cheddar Cheese.

As consumer demand for low-salt diets increases, the development of low-salt cheese has emerged as a prevailing trend. To gain a deeper insight into the effects of salt reduction on cheddar cheese, this study used cheddar cheese with a 2.0% salt concentration (full salt, FS) as the standard control, exploring the differences in quality and composition between cheddar cheese with a 1.

Non-Targeted Metabolomics Analysis Reveals Metabolite Profiles Change During Whey Fermentation with .

Whey fermentation could produce bioactive substances with immunomodulatory effects, metabolic syndrome modulation, and antioxidant properties, thereby imparting functional characteristics to products and facilitating the development of novel foods with health-promoting potential. A non-targeted metabolomics approach using liquid chromatography-mass spectrometry (LC-MS) was employed to investigate changes in the metabolite profiles of whey fermented by strain KM812 over varying fermentation durations. The findings demonstrated a progressive enrichment of metabolites over time.

One new polyketide and four new sesquiterpenes derivatives from the fungicolous fungi aspergillus nidulans LZ8 of Ganoderma lingzhi.

One new polyketide asperfuranone D (1), four new sesquiterpenes derivatives aspergillone C-F (2-5) and three known compounds (6-8) were successfully isolated from Aspergillus nidulans LZ8, a fungicolous fungi from the macrofungal Ganoderma lingzhi. The structures of these compounds were elucidated by extensive spectroscopic analyses including ultraviolet-visible spectroscopy (UV), mass spectrometry (MS), nuclear magnetic resonance (NMR), and electronic circular dichroism (ECD) calculation. In addition, the anti-inflammatory activities of the new compounds were evaluated using LPS-induced RAW 264.

Enantioselective Alkylation of Primary C()-H Bonds in -Methyl Tertiary Amine Enabled by Iridium Complex of Axially Chiral β-Aryl Porphyrins.

A fine-tuning of enantioselective carbene insertion into primary C()-H bonds has been realized in challenging substrates, such as -methyl unblocked aromatic and non-deactivated aliphatic tertiary amines, in which sterically demanding β-axially chiral iridium porphyrin catalysts play a crucial role. This primary C()-H alkylation with diazo compounds affords a series of β-chiral tertiary amines in high yields with excellent enantioselectivities. Notably, the protocol was successfully applied to the postmodification of chiral bicuculline, yielding the desired derivative with high diastereoselectivity.

Total minor ginsenosides exert anti-fatigue effects via antioxidant, anti-inflammatory, regulating gut microbiota and serum metabolism.

Minor ginsenosides have demonstrated notable anti-fatigue capabilities. The aim of this study was to investigate the anti-fatigue mechanisms of total minor ginsenosides (TMGs) derived from a process involving probiotic fermentation and high-pressure steam treatment. The fatigue model was established in BALB/c male mice using weight-bearing swimming and TMGs were administered by orally at a dosage of 200 mg/kg for four weeks.

Anticancer Effects of MZY531 Postbiotics in CT26 Colorectal Tumor-Bearing Mice by Regulating Apoptosis and Autophagy.

has been shown to have anticancer properties. However, there is limited research on the effects of postbiotic on colorectal cancer cell proliferation. Additionally, the exact mechanisms through which it influences apoptosis- and autophagy-related signaling pathways are yet to be thoroughly elucidated.

Modulatory spin-flip of triplet excitons diversiform electron-donating units for MR-TADF emitters towards solution-processed narrowband OLEDs.

Multiple resonance thermally activated delayed fluorescence (MR-TADF) molecules are emerging as promising candidates for high-resolution organic light-emitting diode (OLED) displays, but MR-TADF emitters always suffer from an unsatisfactory rate constant of reverse intersystem crossing ( ) due to inherently low spin orbital coupling strength between excited singlet and triplet states. Herein, we systematically investigate the long-range charge transfer (LRCT) and heavy-atom effects on modulating the excited state natures and energy levels integrating diversiform electron-donating units with the MR skeleton. Compared with unsubstituted analogues, newly designed MR-TADF emitters exhibit significantly boosted values and close-to-unity photoluminescence quantum yield especially for BuCzBN-PXZ (2.

Combination of Lactiplantibacillus Plantarum ELF051 and Astragalus Polysaccharides Improves Intestinal Barrier Function and Gut Microbiota Profiles in Mice with Antibiotic-Associated Diarrhea.

The purpose of this study was to investigate the improvement of the intestinal barrier and gut microbiota in mice with antibiotic-associated diarrhea (AAD) using Lactiplantibacillus plantarum ELF051 combined with Astragalus polysaccharides. The amoxicillin, clindamycin, and streptomycin triple-mixed antibiotic-induced AAD models were administered with L. plantarum ELF051 or Astragalus polysaccharides or L.

Analysis of Brain Protein Stability Changes in a Mouse Model of Alzheimer's Disease.

The stability of proteins from rates of oxidation (SPROX), thermal proteome profiling (TPP), and limited proteolysis (LiP) techniques were used to profile the stability of ∼2500 proteins in hippocampus tissue cell lysates from 2- and 8-months-old wild-type (C57BL/6J; = 7) and transgenic (5XFAD; = 7) mice with five Alzheimer's disease (AD)-linked mutations. Approximately 200-500 protein hits with AD-related stability changes were detected by each technique at each age point. The hit overlap from technique to technique was low, and all of the techniques generated protein hits that were more numerous and largely different from those identified in protein expression level analyses, which were also performed here.

Enhanced Harmonic Partitioned Scheduling of Periodic Real-Time Tasks Based on Slack Analysis.

The adoption of multiprocessor platforms is growing commonplace in Internet of Things (IoT) applications to handle large volumes of sensor data while maintaining real-time performance at a reasonable cost and with low power consumption. Partitioned scheduling is a competitive approach to ensure the temporal constraints of real-time sensor data processing tasks on multiprocessor platforms. However, the problem of partitioning real-time sensor data processing tasks to individual processors is strongly NP-hard, making it crucial to develop efficient partitioning heuristics to achieve high real-time performance.

Variations in water use strategies of at coppice dunes along a precipitation gradient in desert regions of northwest China.

Introduction: The precipitation pattern has changed significantly in arid desert areas, yet it is not clear how the water use strategies of Tamarix ramosissima Ledeb. on coppice dunes along a natural precipitation gradient are affected.

Methods: In this study, the hydrogen and oxygen isotope compositions of xylem water, soil water, precipitation, and groundwater were measured by stable isotope techniques in Huocheng, Mosuowan, and Tazhong.

Regulatory T Cell as Predictor of Intramyocardial Hemorrhage in STEMI Patients after Primary PCI.

Background: Intramyocardial hemorrhage (IMH) is a result of ischemia-reperfusion injury in ST-segment elevation myocardial infarction (STEMI) after primary percutaneous coronary intervention (PPCI). Despite patients with IMH show poorer prognoses, studies investigating predictors of IMH occurrence are scarce. This study firstly investigated the effectiveness of regulatory T cell (Treg), peak value of Creatine Kinase MB (pCKMB), high-sensitivity C-reactive protein (hsCRP), and left ventricular end-systolic diameter (LVESD) as predictors for IMH.

Benzothiadiazole-Based Ordered Mesoporous Polymer as a Versatile, Metal-Free Heterogeneous Photocatalyst.

Visible-light active heterogeneous organophotocatalysts have recently gained considerable interest in organic synthetic community. Ordered mesoporous polymers (OMPs) are highly promising as heterogeneous alternative to traditional precious metal/organic dyes-based photocatalysts. Herein, we report the preparation of a benzothiadiazole functionalized OMPs (BT-MPs) through a "bottom-up" strategy.

Assessment of site suitability for centralized photovoltaic power stations in Northwest China's six provinces.

Northwest China has abundant solar energy resources and extensive land, making it a pivotal site for solar energy development. However, restrictions on site selection and severe weather conditions have hindered the establishment and operation of photovoltaic (PV) power stations. Previous studies have not considered meteorological factors when evaluating site suitability, leading to research gaps in identifying suitable areas and establishing indicator systems.

A Potential Role for MAGI-1 in the Bi-Directional Relationship Between Major Depressive Disorder and Cardiovascular Disease.

Purpose Of Review: Major Depressive Disorder (MDD) is characterized by persistent symptoms such as fatigue, loss of interest in activities, feelings of sadness and worthlessness. MDD often coexist with cardiovascular disease (CVD), yet the precise link between these conditions remains unclear. This review explores factors underlying the development of MDD and CVD, including genetic, epigenetic, platelet activation, inflammation, hypothalamic-pituitary-adrenal (HPA) axis activation, endothelial cell (EC) dysfunction, and blood-brain barrier (BBB) disruption.