Chemical Synthesis and Antigenicity Evaluation of an Aminoglycoside Trisaccharide Repeating Unit of Serotype O5 O-Antigen Containing a Rare Dimeric-ManN3NA.

bacteria are becoming increasingly resistant against multiple antibiotics. Therefore, the development of vaccines to prevent infections with these bacteria is an urgent medical need. While the immunological activity of lipopolysaccharide O-antigens in is well-known, the specific protective epitopes remain unidentified.

New Horizons in Probiotics: Unraveling the Potential of Edible Microbial Polysaccharides through In Vitro Digestion Models.

In vitro digestion models, as innovative assessment tools, possess advantages such as speed, high throughput, low cost, and high repeatability. They have been widely applied to the investigation of food digestion behavior and its potential impact on health. In recent years, research on edible polysaccharides in the field of intestinal health has been increasing.

Chemical Synthesis and Antigenicity Evaluation of Serotype 10 O-Antigen Tetrasaccharide Containing a ()-4,6--Pyruvyl Ketal.

is the second most common etiologic pathogen responsible for childhood acute diarrhea. An anti- vaccine is still eagerly awaited due to the increasing drug resistance of this pathogen. The O-antigen is a promising vaccine target.

The role of Se content in improving anti-tumor activities and its potential mechanism for selenized polysaccharides.

Drawing an instructive point on the correlation between Se content and anti-tumor effects is helpful to develop Se-polysaccharides with potential anti-tumor activities. In this work, Se content-related anti-tumor activities are assessed in vitro by multiple comparisons among Na2SeO3, Artemisia sphaerocephala polysaccharide (ASP), and selenized ASP (SeASPs, Se contents 4344-13 030 μg g-1) synthesized by a chemical modification method. The results suggest that SeASPs exhibit potent anti-proliferation activities against three kinds of tumor cells by inducing apoptosis and cell cycle arrest, which is positively correlated to Se content.

Acid site-regulated solid acids for polysaccharide Se-functionalization: Structural explanations for high reactivity.

In this work, the application of acid site-regulated solid acids in Se-functionalization of polysaccharide is evaluated for the first time, which aimed to further improve reaction efficiency and realize environmentally friendly chemistry. A series prepared MO/HZSM-5 catalysts possesses standard crystal structure, large specific surface area, pore volume, aperture as well as strong acidity. An efficient substitution of seleno-group on polysaccharide backbone is promoted by regulating the acid site of solid acids (Se content up to 15,170.

Synthesis of Se-polysaccharide mediated by selenium oxychloride: Structure features and antiproliferative activity.

Selenium oxychloride (SOC) was employed as a highly reactive selenide reagent to synthesize selenized Artemisia sphaerocephala polysaccharides (SeASP). Se content of SeASP was significantly increased (∼22,400 μg/g) as compared to HNO/HSeO selenylation method (1703 μg/g). Furthermore, selenized ASP was prepared by using microwave-assisted synthesis which obviously enhanced selenylation kinetics.

A comparative study of sulfated tara gum: RSM optimization and structural characterization.

Interest in galactomannans and its derivatives as a functional health supplement is growing based on physicochemical properties. In this work, the optimized conditions of sulfated tara gum (STG) with a maximum DS of 0.66 by box-behnken design (BBD) were obtained as following: ratio of chlorosulfonic acid/pyridine 3:1, reaction time 4 h and reaction temperature 40 °C.