A Machine Learning Strategy for Drug Discovery Identifies Anti-Schistosomal Small Molecules.

Schistosomiasis is a chronic and painful disease of poverty caused by the flatworm parasite . Drug discovery for antischistosomal compounds predominantly employs whole organism (phenotypic) screens against two developmental stages of , post-infective larvae (somules) and adults. We generated two rule books and associated scoring systems to normalize 3898 phenotypic data points to enable machine learning.