Publications by authors named "Shengsong Gou"
Lysine β-hydroxybutyrylation (Kbhb) is a post-translational modification induced by the ketogenic diet (KD), a diet showing therapeutic effects on multiple human diseases. Little is known how cellular processes are regulated by Kbhb. Here we show that protein Kbhb is strongly affected by the KD through a multi-omics analysis of mouse livers.
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- The global rise in life expectancy often does not translate to improved health span, highlighting the need to understand how aging affects behavior, especially motor skills in the elderly.
- Researchers conducted a genome-wide screening in the roundworm Caenorhabditis elegans and identified 34 genes related to motor aging, focusing on VPS-34, a key regulator in motor function.
- VPS-34 affects neurotransmission in aged motor neurons and targeting it through genetic or drug manipulation showed promise in enhancing muscle function and delaying motor aging in both worms and mice.