[Primary Pharmacodynamic Study on Chuanping Dropping Pills].

Objective: To study the antitussive, antiasthmatic, and expectorant effects of Chuanoing dropping pills.

Methods: Histamine-acetylcholine induced asthma, ovalbumin sensitization, pulmonary overflow, spiral strip trachea of guinea pig, lung strip of guinea pig, ammonia water or citric acid induced cough of mice, and phenol red expectoration of mice were carried out.

Results: Chuanping dripping pills significantly prolonged the incubation induced by histamine-acetylcholine, reduced the reaction stage of ovalbumin sensitization of guinea pig with asthma, inhibited the increase of pulmonary overflow on histamine induced asthma, reduced the contraction of smooth muscle and lung strip by histamine induced asthma on guinea pig, reduced cough times on ammonia or citrate acid caused mice, and increased the output on mice tracheal phenol red.

[Correlation between dissolution in vitro and absorption in vivo of chuanping sustained release tablets].

Objective: To investigate the correlation between dissolution in vitro and absorption in vivo of Chuanping sustained release tablets.

Method: The ephedrine, pseudoephedrine were chosen as marker components, dissolution in vitro of Chuanping sustained release tablets in the different pH were tested by the rotating basket method and HPLC; urine drug levels were determined by HPLC and absorption fractions were calculated according to Wagner-Nelson's formula and deconvolution technique.

Result: The linear regressive equation between the absorption percentage in vivo F and accumulative release percentage in vitro of Chuanping sustained release tablets was established as F(ephedrine) = 1.

[Evaluation of balanced release of complex components of Chuanping sustained tablets based on fingerprint].

To combine fingerprint and drug release rate in vitro, in order to study in vitro release of complex components of Chuanping sustained tablets, compound traditional Chinese medicine preparation. A qualitative determination of the characteristic peaks of the compound preparations were conducted by the fingerprint. The results of the dissolution rate determination under different release conditions showed that the release of three index components (methamphetamine, pseudoephedrine and scopolamine) of Chuanping sustained tablets was less affected by gastrointestinal factors, with similarity factors being more than 80 with unknown component release curves of three major characteristic peaks in the fingerprint.

[Prediction of absorption of 10-hydroxycamptothecin in small intestines of rats with its partition coefficients in phases of liposomes and water].

This paper explore the possibility of using the partition of 10-hydroxycamptothecin in the phases of liposome and water to predict the absorption of the drug in small intestine of rats. In order to certify this theory, the in vivo absorption model have been used to study the absorption of 10-hydroxycamptothecin in the small intestine of rats while altering the pH of the medium. The correlation has been explored between the partition of drug in the phases of liposome and water and the absorption of drug in the small intestines of rats.

[Study on dissolution in vitro of Zhike Pingchuan sustained-release tablets].

Objective: To establish a method to evaluate the in vitro release of Zhike Pingchuan sustained-release tablets.

Method: The ephedrine, pseudoephedrine, scopolamine were chosen as marker components components, and the chromatographic conditions were chosen according to the separation of baseline and theoretical plate number for determining the marker in vitro release of Zhike Pingchuan sustained-release tablets; through the dissolution curves of the three active components, the release behavior was judged as well-balanced release or not.

Result: Compared with conventional tablets, the Zhike Pingchuan sustained-release tablets had a well-balanced behavior in 10 h.

[Quality analysis of Radix Salviae Miltiorrhizae from different habitats by HPLC and TLC].

Objective: To analyze and compare the composition of Radix Salviae Miltiorrhizae from different habitats by HPLC and TLC.

Methods: The fingerprints of Radix Salviae Miltiorrhizae were detected by HPLC and TLC.

Results: Radix Salviae Miltiorrhiza collected from different habitats showed diverse fingerprints of component.