Publications by authors named "Shengqian Deng"
Background: Acute pharyngitis (AP) is a common condition marked by inflammation of the oropharynx, which can lead to severe throat swelling, breathing difficulties, and even suffocation, significantly impacting quality of life. Despite the beneficial anti-inflammatory activity of Glycyrrhizae Radix Et Rhizoma (GRER) and Isoliquiritigenin (ISL), their pharmacological mechanisms against AP remain unclear.
Purpose: This study explores the mechanisms by which GRER treats AP, utilizing both transcriptomics and metabolomics approaches.
Article Synopsis
- ABT-199 is a BCL-2 suppressor used to treat acute myeloid leukemia (AML), but some cells develop resistance, raising questions about its effectiveness, especially when combined with drugs like azacitidine.
- Usnic acid, derived from lichen, shows anticancer potential and may help overcome this resistance by targeting stress response pathways.
- The study found that low doses of usnic acid restored sensitivity to ABT-199 in resistant AML cells by enhancing stress response gene expression and promoting the breakdown of the anti-apoptotic protein MCL-1.